Inflammatory, immune, and viral aspects of inclusion-body myositis

Muscle biopsies from patients with sporadic inclusion-body myositis (sIBM) consistently demonstrate that the inflammatory T cells almost invariably invade intact (not vacuolated) fibers, whereas the vacuolated fibers are rarely invaded by T cells. This indicates two concurrently ongoing processes, a...

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Veröffentlicht in:	Neurology 2006-01, Vol.66 (2 Suppl 1), p.S33-S38
1. Verfasser:	Dalakas, Marinos C
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Amyloid - metabolism Autoimmune Diseases - etiology Autoimmune Diseases - immunology Autoimmune Diseases - pathology Chemokines - physiology Cytokines - physiology Disease Progression Drug Resistance Female Gene Rearrangement, T-Lymphocyte Genetic Predisposition to Disease HIV Infections - complications HLA Antigens - analysis HTLV-I Infections - complications Human immunodeficiency virus Human T-lymphotropic virus 1 Humans Male Metalloproteases - physiology Middle Aged Muscle Fibers, Skeletal - immunology Muscle Fibers, Skeletal - pathology Myositis, Inclusion Body - etiology Myositis, Inclusion Body - immunology Myositis, Inclusion Body - pathology Myositis, Inclusion Body - therapy Paraproteinemias - complications T-Lymphocyte Subsets - immunology T-Lymphocyte Subsets - pathology Vacuoles - ultrastructure
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