Design and cellular kinetics of dansyl-labeled CADA derivatives with anti-HIV and CD4 receptor down-modulating activity

A new class of anti-retrovirals, cyclotriazadisulfonamide (CADA) and its derivatives, specifically down-regulate CD4, the main receptor of HIV, and prevent HIV infection in vitro. In this work, several CADA derivatives, chemically labeled with a fluorescent dansyl group, were evaluated for their bio...

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Veröffentlicht in:	Biochemical pharmacology 2007-08, Vol.74 (4), p.566-578
Hauptverfasser:	Vermeire, Kurt, Lisco, Andrea, Grivel, Jean-Charles, Scarbrough, Emily, Dey, Kaka, Duffy, Noah, Margolis, Leonid, Bell, Thomas W., Schols, Dominique
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-HIV Anti-HIV Agents - chemical synthesis Anti-HIV Agents - metabolism Anti-HIV Agents - pharmacology Biological and medical sciences CADA CD4 Antigens - genetics CD4 Antigens - metabolism CD4 receptor CD4-Positive T-Lymphocytes - cytology CD4-Positive T-Lymphocytes - drug effects CD4-Positive T-Lymphocytes - metabolism Cell Line Cell Line, Tumor Cell Survival - drug effects Cellular kinetics Dansyl Dansyl Compounds - chemical synthesis Dansyl Compounds - chemistry Dansyl Compounds - metabolism Dansyl Compounds - pharmacology Dimethyl Sulfoxide - chemistry Dose-Response Relationship, Drug Down-Regulation - drug effects Drug Design Flow Cytometry Heterocyclic Compounds - chemical synthesis Heterocyclic Compounds - metabolism Heterocyclic Compounds - pharmacology HIV-1 - drug effects HIV-1 - growth & development Human immunodeficiency virus Humans Immunohistochemistry Kinetics Medical sciences Molecular Structure Pharmacology. Drug treatments Poloxamer - chemistry Reversible Down-modulation Solvents - chemistry Spectrometry, Fluorescence Sulfonamides - chemical synthesis Sulfonamides - chemistry Sulfonamides - pharmacology Surface-Active Agents - chemistry Transfection
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