Synthetic inotropes inhibit the expression of adhesion molecules and augment the expression of l -selectin in polymorphonuclear neutrophils

Summary Objectives To elucidate differential functional and phenotypic changes in response to clinically relevant synthetic inotropes plus the generation of oxidative free radicals by polymorphonuclear neutrophils (PMN), and changes in the expression of l -selectin and Mac-1 on the surface of PMN we...

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Veröffentlicht in:	Resuscitation 2007-08, Vol.74 (2), p.352-356
Hauptverfasser:	Trabold, B, Gruber, M, Fröhlich, D
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis of Variance Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Antigens, CD - biosynthesis Antigens, CD - drug effects Biological and medical sciences Blood. Blood coagulation. Reticuloendothelial system Cardiotonic Agents - pharmacology Dobutamine Dobutamine - administration & dosage Dobutamine - pharmacology Dopamine - administration & dosage Dopamine - analogs & derivatives Dopamine - pharmacology Dopexamine Dose-Response Relationship, Drug Emergency Flow Cytometry Free Radicals - metabolism Fundamental and applied biological sciences. Psychology Humans Hydrogen Peroxide - metabolism Inotropes Intensive care medicine l-Selectin L-Selectin - biosynthesis Mac-1 Macrophage-1 Antigen - biosynthesis Medical sciences Neutrophil Activation - drug effects Neutrophils - drug effects Neutrophils - immunology Neutrophils - metabolism Pharmacology. Drug treatments Phenotype Polymorphonuclear neutrophils Prospective Studies Respiratory burst Respiratory Burst - drug effects Up-Regulation Vertebrates: blood, hematopoietic organs, reticuloendothelial system
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