Palladium-Catalyzed Selective Cross-Addition of Triisopropylsilylacetylene to Internal and Terminal Unactivated Alkynes

Palladium-Catalyzed Selective Cross-Addition of Triisopropylsilylacetylene to Internal and Terminal Unactivated Alkynes

Dinuclear and mononuclear palladium complexes having N,N‘-bis[2-(diphenylphosphino)phenyl]amidinate (DPFAM) as a ligand catalyzed the cross-addition of triisopropylsilylacetylene (TIPSA) to unactivated internal alkynes, giving enynes selectively. When palladium catalysts having PPh3, TDMPP, dppe, or...

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Veröffentlicht in:Organic letters 2007-07, Vol.9 (15), p.2919-2921
Hauptverfasser: Tsukada, Naofumi, Ninomiya, Satoshi, Aoyama, Yoshimi, Inoue, Yoshio
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container_title Organic letters
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creator Tsukada, Naofumi
Ninomiya, Satoshi
Aoyama, Yoshimi
Inoue, Yoshio
description Dinuclear and mononuclear palladium complexes having N,N‘-bis[2-(diphenylphosphino)phenyl]amidinate (DPFAM) as a ligand catalyzed the cross-addition of triisopropylsilylacetylene (TIPSA) to unactivated internal alkynes, giving enynes selectively. When palladium catalysts having PPh3, TDMPP, dppe, or dppf were used, dimers of TIPSA were obtained as major products. The reactions of TIPSA with several terminal alkynes also gave cross-adducts selectively, although the yields were moderate.
doi_str_mv 10.1021/ol071326g
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title Palladium-Catalyzed Selective Cross-Addition of Triisopropylsilylacetylene to Internal and Terminal Unactivated Alkynes
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