Bone mineral density and bone markers in patients with a recent low-energy fracture: effect of 1 y of treatment with calcium and vitamin D
BACKGROUND: Low-energy fractures of the hip, forearm, shoulder, and spine are known consequences of osteoporosis. OBJECTIVE: We evaluated the effect of 1 y of treatment with calcium and vitamin D on bone mineral density (BMD) and bone markers in patients with a recent low-energy fracture. DESIGN: In...
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| description | BACKGROUND: Low-energy fractures of the hip, forearm, shoulder, and spine are known consequences of osteoporosis. OBJECTIVE: We evaluated the effect of 1 y of treatment with calcium and vitamin D on bone mineral density (BMD) and bone markers in patients with a recent low-energy fracture. DESIGN: In a double-blinded design, patients with fracture of the hip (lower-extremity fracture, or LEF) or upper extremity (UEF) were randomly assigned to receive 3000 mg calcium carbonate + 1400 IU cholecalciferol or placebo (200 IU cholecalciferol). BMD of the hip (HBMD) and lumbar spine (LBMD) were evaluated by dual-energy X-ray absorptiometry, and physical performance was assessed by the timed Up & Go test. Serum concentrations of 25-hydroxycholecalciferol, parathyroid hormone (PTH), telepeptide of type I collagen (ICTP), osteocalcin, and N-terminal propeptide of collagen type I were measured. RESULTS: A total of 122 patients were included (84% women; x ± SD age: 70 ± 11 y); 68% completed the study. In an intention-to-treat analysis, LBMD increased in the intervention group and decreased in the placebo group, and the difference between the groups was significant after 12 mo: 0.931 ± 0.211 compared with 0.848 ± 0.194 (P < 0.05). No significant change was shown for HBMD. The effect of treatment was more pronounced in patients aged |
| doi_str_mv | 10.1093/ajcn/86.1.251 |
| format | Article |
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OBJECTIVE: We evaluated the effect of 1 y of treatment with calcium and vitamin D on bone mineral density (BMD) and bone markers in patients with a recent low-energy fracture. DESIGN: In a double-blinded design, patients with fracture of the hip (lower-extremity fracture, or LEF) or upper extremity (UEF) were randomly assigned to receive 3000 mg calcium carbonate + 1400 IU cholecalciferol or placebo (200 IU cholecalciferol). BMD of the hip (HBMD) and lumbar spine (LBMD) were evaluated by dual-energy X-ray absorptiometry, and physical performance was assessed by the timed Up & Go test. Serum concentrations of 25-hydroxycholecalciferol, parathyroid hormone (PTH), telepeptide of type I collagen (ICTP), osteocalcin, and N-terminal propeptide of collagen type I were measured. RESULTS: A total of 122 patients were included (84% women; x ± SD age: 70 ± 11 y); 68% completed the study. In an intention-to-treat analysis, LBMD increased in the intervention group and decreased in the placebo group, and the difference between the groups was significant after 12 mo: 0.931 ± 0.211 compared with 0.848 ± 0.194 (P < 0.05). No significant change was shown for HBMD. The effect of treatment was more pronounced in patients aged <70 y. The intervention decreased bone turnover. PTH was significantly lower in the intervention group (P < 0.01) for the LEF patients. ICTP and change in LBMD were significantly related to physical performance. CONCLUSIONS: A 1-y intervention with calcium and vitamin D reduced bone turnover, significantly increased BMD in patients younger than 70 y, and decreased bone loss in older patients. The effect of treatment was related to physical performance.</description><identifier>ISSN: 0002-9165</identifier><identifier>EISSN: 1938-3207</identifier><identifier>DOI: 10.1093/ajcn/86.1.251</identifier><identifier>PMID: 17616788</identifier><identifier>CODEN: AJCNAC</identifier><language>eng</language><publisher>Bethesda, MD: American Society for Nutrition</publisher><subject>25-hydroxycholecalciferol ; Absorptiometry, Photon ; adults ; age ; Aged ; Biological and medical sciences ; biomarkers ; Biomarkers - blood ; Bone and Bones - drug effects ; Bone and Bones - metabolism ; bone density ; Bone Density - drug effects ; bone fractures ; bone metabolism ; bone mineralization ; Bone Remodeling - drug effects ; Bone Remodeling - physiology ; bone resorption ; calcium ; Calcium Carbonate - blood ; Calcium Carbonate - pharmacology ; Cholecalciferol - blood ; Cholecalciferol - pharmacology ; collagen ; Collagen Type I ; dosage ; Double-Blind Method ; elderly ; Feeding. Feeding behavior ; Female ; Fractures, Bone - pathology ; Fractures, Bone - prevention & control ; Fundamental and applied biological sciences. Psychology ; health status ; Humans ; Linear Models ; low-energy fracture ; Male ; men ; Middle Aged ; Osteocalcin - blood ; parathyroid hormone ; Parathyroid Hormone - blood ; patients ; Peptide Fragments - blood ; Peptides ; Procollagen - blood ; Prospective Studies ; protein subunits ; Vertebrates: anatomy and physiology, studies on body, several organs or systems ; vitamin D ; vitamin-mineral supplements ; women</subject><ispartof>The American journal of clinical nutrition, 2007-07, Vol.86 (1), p.251-259</ispartof><rights>2007 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c415t-2873b7da41a2161ee7398537e7c588433c6b47ac43d9fe392dc9bd6c4bb5b98a3</citedby><cites>FETCH-LOGICAL-c415t-2873b7da41a2161ee7398537e7c588433c6b47ac43d9fe392dc9bd6c4bb5b98a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=18933636$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17616788$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hitz, Mette F</creatorcontrib><creatorcontrib>Jensen, Jens-Erik B</creatorcontrib><creatorcontrib>Eskildsen, Peter C</creatorcontrib><title>Bone mineral density and bone markers in patients with a recent low-energy fracture: effect of 1 y of treatment with calcium and vitamin D</title><title>The American journal of clinical nutrition</title><addtitle>Am J Clin Nutr</addtitle><description>BACKGROUND: Low-energy fractures of the hip, forearm, shoulder, and spine are known consequences of osteoporosis. OBJECTIVE: We evaluated the effect of 1 y of treatment with calcium and vitamin D on bone mineral density (BMD) and bone markers in patients with a recent low-energy fracture. DESIGN: In a double-blinded design, patients with fracture of the hip (lower-extremity fracture, or LEF) or upper extremity (UEF) were randomly assigned to receive 3000 mg calcium carbonate + 1400 IU cholecalciferol or placebo (200 IU cholecalciferol). BMD of the hip (HBMD) and lumbar spine (LBMD) were evaluated by dual-energy X-ray absorptiometry, and physical performance was assessed by the timed Up & Go test. Serum concentrations of 25-hydroxycholecalciferol, parathyroid hormone (PTH), telepeptide of type I collagen (ICTP), osteocalcin, and N-terminal propeptide of collagen type I were measured. RESULTS: A total of 122 patients were included (84% women; x ± SD age: 70 ± 11 y); 68% completed the study. In an intention-to-treat analysis, LBMD increased in the intervention group and decreased in the placebo group, and the difference between the groups was significant after 12 mo: 0.931 ± 0.211 compared with 0.848 ± 0.194 (P < 0.05). No significant change was shown for HBMD. The effect of treatment was more pronounced in patients aged <70 y. The intervention decreased bone turnover. PTH was significantly lower in the intervention group (P < 0.01) for the LEF patients. ICTP and change in LBMD were significantly related to physical performance. CONCLUSIONS: A 1-y intervention with calcium and vitamin D reduced bone turnover, significantly increased BMD in patients younger than 70 y, and decreased bone loss in older patients. The effect of treatment was related to physical performance.</description><subject>25-hydroxycholecalciferol</subject><subject>Absorptiometry, Photon</subject><subject>adults</subject><subject>age</subject><subject>Aged</subject><subject>Biological and medical sciences</subject><subject>biomarkers</subject><subject>Biomarkers - blood</subject><subject>Bone and Bones - drug effects</subject><subject>Bone and Bones - metabolism</subject><subject>bone density</subject><subject>Bone Density - drug effects</subject><subject>bone fractures</subject><subject>bone metabolism</subject><subject>bone mineralization</subject><subject>Bone Remodeling - drug effects</subject><subject>Bone Remodeling - physiology</subject><subject>bone resorption</subject><subject>calcium</subject><subject>Calcium Carbonate - blood</subject><subject>Calcium Carbonate - pharmacology</subject><subject>Cholecalciferol - blood</subject><subject>Cholecalciferol - pharmacology</subject><subject>collagen</subject><subject>Collagen Type I</subject><subject>dosage</subject><subject>Double-Blind Method</subject><subject>elderly</subject><subject>Feeding. Feeding behavior</subject><subject>Female</subject><subject>Fractures, Bone - pathology</subject><subject>Fractures, Bone - prevention & control</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>health status</subject><subject>Humans</subject><subject>Linear Models</subject><subject>low-energy fracture</subject><subject>Male</subject><subject>men</subject><subject>Middle Aged</subject><subject>Osteocalcin - blood</subject><subject>parathyroid hormone</subject><subject>Parathyroid Hormone - blood</subject><subject>patients</subject><subject>Peptide Fragments - blood</subject><subject>Peptides</subject><subject>Procollagen - blood</subject><subject>Prospective Studies</subject><subject>protein subunits</subject><subject>Vertebrates: anatomy and physiology, studies on body, several organs or systems</subject><subject>vitamin D</subject><subject>vitamin-mineral supplements</subject><subject>women</subject><issn>0002-9165</issn><issn>1938-3207</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqF0cluFDEQBmALgchk4MgVfCG3nnjp9sIthFWKxAFytqrd1cGhl8F2E80r8NR4FilH5EPJ8lcuqX5CXnG24czKS7j306VRG74RDX9CVtxKU0nB9FOyYoyJynLVnJHzlO4Z46I26jk541pxpY1Zkb_v5wnpGCaMMNAOpxTyjsLU0fbwAPEXxkTDRLeQA0450YeQf1KgEX250mF-qLB03-1oH8HnJeI7in2PPtO5p5zu9iVHhDzu_aHbw-DDMh7m_AkZynz64QV51sOQ8OWprsntp48_rr9UN98-f72-uql8zZtcCaNlqzuoOQiuOKKW1jRSo_aNMbWUXrW1Bl_LzvYorei8bTvl67ZtWmtArsnF8d9tnH8vmLIbQ_I4DDDhvCSnmWaSS_FfKFhjm9qYAqsj9HFOKWLvtjGU1e0cZ26fktun5Ixy3JWUin99-nhpR-we9SmWAt6eAKSyq7LYyYf06IyVUpWzJm-OrofZwV0s5va7YFwypo3WRfwDjQelCA</recordid><startdate>20070701</startdate><enddate>20070701</enddate><creator>Hitz, Mette F</creator><creator>Jensen, Jens-Erik B</creator><creator>Eskildsen, Peter C</creator><general>American Society for Nutrition</general><general>American Society for Clinical Nutrition</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7X8</scope></search><sort><creationdate>20070701</creationdate><title>Bone mineral density and bone markers in patients with a recent low-energy fracture: effect of 1 y of treatment with calcium and vitamin D</title><author>Hitz, Mette F ; Jensen, Jens-Erik B ; Eskildsen, Peter C</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c415t-2873b7da41a2161ee7398537e7c588433c6b47ac43d9fe392dc9bd6c4bb5b98a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>25-hydroxycholecalciferol</topic><topic>Absorptiometry, Photon</topic><topic>adults</topic><topic>age</topic><topic>Aged</topic><topic>Biological and medical sciences</topic><topic>biomarkers</topic><topic>Biomarkers - blood</topic><topic>Bone and Bones - drug effects</topic><topic>Bone and Bones - metabolism</topic><topic>bone density</topic><topic>Bone Density - drug effects</topic><topic>bone fractures</topic><topic>bone metabolism</topic><topic>bone mineralization</topic><topic>Bone Remodeling - drug effects</topic><topic>Bone Remodeling - physiology</topic><topic>bone resorption</topic><topic>calcium</topic><topic>Calcium Carbonate - blood</topic><topic>Calcium Carbonate - pharmacology</topic><topic>Cholecalciferol - blood</topic><topic>Cholecalciferol - pharmacology</topic><topic>collagen</topic><topic>Collagen Type I</topic><topic>dosage</topic><topic>Double-Blind Method</topic><topic>elderly</topic><topic>Feeding. Feeding behavior</topic><topic>Female</topic><topic>Fractures, Bone - pathology</topic><topic>Fractures, Bone - prevention & control</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>health status</topic><topic>Humans</topic><topic>Linear Models</topic><topic>low-energy fracture</topic><topic>Male</topic><topic>men</topic><topic>Middle Aged</topic><topic>Osteocalcin - blood</topic><topic>parathyroid hormone</topic><topic>Parathyroid Hormone - blood</topic><topic>patients</topic><topic>Peptide Fragments - blood</topic><topic>Peptides</topic><topic>Procollagen - blood</topic><topic>Prospective Studies</topic><topic>protein subunits</topic><topic>Vertebrates: anatomy and physiology, studies on body, several organs or systems</topic><topic>vitamin D</topic><topic>vitamin-mineral supplements</topic><topic>women</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hitz, Mette F</creatorcontrib><creatorcontrib>Jensen, Jens-Erik B</creatorcontrib><creatorcontrib>Eskildsen, Peter C</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>The American journal of clinical nutrition</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hitz, Mette F</au><au>Jensen, Jens-Erik B</au><au>Eskildsen, Peter C</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Bone mineral density and bone markers in patients with a recent low-energy fracture: effect of 1 y of treatment with calcium and vitamin D</atitle><jtitle>The American journal of clinical nutrition</jtitle><addtitle>Am J Clin Nutr</addtitle><date>2007-07-01</date><risdate>2007</risdate><volume>86</volume><issue>1</issue><spage>251</spage><epage>259</epage><pages>251-259</pages><issn>0002-9165</issn><eissn>1938-3207</eissn><coden>AJCNAC</coden><abstract>BACKGROUND: Low-energy fractures of the hip, forearm, shoulder, and spine are known consequences of osteoporosis. OBJECTIVE: We evaluated the effect of 1 y of treatment with calcium and vitamin D on bone mineral density (BMD) and bone markers in patients with a recent low-energy fracture. DESIGN: In a double-blinded design, patients with fracture of the hip (lower-extremity fracture, or LEF) or upper extremity (UEF) were randomly assigned to receive 3000 mg calcium carbonate + 1400 IU cholecalciferol or placebo (200 IU cholecalciferol). BMD of the hip (HBMD) and lumbar spine (LBMD) were evaluated by dual-energy X-ray absorptiometry, and physical performance was assessed by the timed Up & Go test. Serum concentrations of 25-hydroxycholecalciferol, parathyroid hormone (PTH), telepeptide of type I collagen (ICTP), osteocalcin, and N-terminal propeptide of collagen type I were measured. RESULTS: A total of 122 patients were included (84% women; x ± SD age: 70 ± 11 y); 68% completed the study. In an intention-to-treat analysis, LBMD increased in the intervention group and decreased in the placebo group, and the difference between the groups was significant after 12 mo: 0.931 ± 0.211 compared with 0.848 ± 0.194 (P < 0.05). No significant change was shown for HBMD. The effect of treatment was more pronounced in patients aged <70 y. The intervention decreased bone turnover. PTH was significantly lower in the intervention group (P < 0.01) for the LEF patients. ICTP and change in LBMD were significantly related to physical performance. CONCLUSIONS: A 1-y intervention with calcium and vitamin D reduced bone turnover, significantly increased BMD in patients younger than 70 y, and decreased bone loss in older patients. The effect of treatment was related to physical performance.</abstract><cop>Bethesda, MD</cop><pub>American Society for Nutrition</pub><pmid>17616788</pmid><doi>10.1093/ajcn/86.1.251</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | 25-hydroxycholecalciferol Absorptiometry, Photon adults age Aged Biological and medical sciences biomarkers Biomarkers - blood Bone and Bones - drug effects Bone and Bones - metabolism bone density Bone Density - drug effects bone fractures bone metabolism bone mineralization Bone Remodeling - drug effects Bone Remodeling - physiology bone resorption calcium Calcium Carbonate - blood Calcium Carbonate - pharmacology Cholecalciferol - blood Cholecalciferol - pharmacology collagen Collagen Type I dosage Double-Blind Method elderly Feeding. Feeding behavior Female Fractures, Bone - pathology Fractures, Bone - prevention & control Fundamental and applied biological sciences. Psychology health status Humans Linear Models low-energy fracture Male men Middle Aged Osteocalcin - blood parathyroid hormone Parathyroid Hormone - blood patients Peptide Fragments - blood Peptides Procollagen - blood Prospective Studies protein subunits Vertebrates: anatomy and physiology, studies on body, several organs or systems vitamin D vitamin-mineral supplements women |
| title | Bone mineral density and bone markers in patients with a recent low-energy fracture: effect of 1 y of treatment with calcium and vitamin D |
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