Flavopiridol disrupts STAT3/DNA interactions, attenuates STAT3-directed transcription, and combines with the Jak kinase inhibitor AG490 to achieve cytotoxic synergy

Up-regulated signal transducers and activators of transcription (STAT)–mediated signaling is believed to contribute to the pathogenesis of a variety of solid and hematologic cancers. Consequently, inhibition of STAT-mediated signaling has recently been proposed as a potential new therapeutic approac...

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Veröffentlicht in:	Molecular cancer therapeutics 2006-01, Vol.5 (1), p.138-148
Hauptverfasser:	Lee, Yean Kit, Isham, Crescent R, Kaufman, Scott H, Bible, Keith C
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic Combined Chemotherapy Protocols Carcinoma, Non-Small-Cell Lung - drug therapy Carcinoma, Non-Small-Cell Lung - pathology CDKs and CDK inhibitors DNA - metabolism Down-Regulation Drug Screening Assays, Antitumor Enzyme Inhibitors - pharmacology Flavonoids - administration & dosage Flavonoids - pharmacology Humans Janus Kinase 1 Lung Neoplasms - drug therapy Lung Neoplasms - pathology Mechanisms of drug action Myeloid Cell Leukemia Sequence 1 Protein Neoplasm Proteins - drug effects Neoplasm Proteins - genetics Phosphoproteins - drug effects Phosphoproteins - metabolism Piperidines - administration & dosage Piperidines - pharmacology Protein-Tyrosine Kinases - antagonists & inhibitors Proto-Oncogene Proteins c-bcl-2 - drug effects Proto-Oncogene Proteins c-bcl-2 - genetics RNA Polymerase II - drug effects RNA Polymerase II - metabolism STAT3 Transcription Factor - drug effects STAT3 Transcription Factor - genetics STAT3 Transcription Factor - metabolism Transcription, Genetic Tumor Cells, Cultured Tyrphostins - pharmacology
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