Ceramide regulates SR protein phosphorylation during adenoviral infection

In this study, we show that adenoviral infection induced accumulation of the sphingolipid ceramide in a dose- and time-dependent manner. This accumulation preceded cell lysis, occurred in the absence of biochemical evidence of apoptosis, and was derived from de novo synthesis of ceramide. An adenovi...

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Veröffentlicht in:	Virology (New York, N.Y.) N.Y.), 2006-02, Vol.345 (1), p.280-289
Hauptverfasser:	Kanj, Souha S., Dandashi, Nadine, El-Hed, Aimee, Harik, Hisham, Maalouf, Maria, Kozhaya, Lina, Mousallem, Talal, Tollefson, Ann E., Wold, William S., Chalfant, Charles E., Dbaibo, Ghassan S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenoviridae - physiology Adenovirus Blotting, Western Cell Death Cell Line Cell lysis Ceramide Ceramides - antagonists & inhibitors Ceramides - biosynthesis Ceramides - metabolism Collagen Type XI - metabolism Enzyme Inhibitors - pharmacology Humans Lipid mediators Phosphoproteins - metabolism Phosphorylation Proteins - chemistry Proteins - metabolism Serine-Arginine Splicing Factors SR proteins
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