Expression of MMP-7 and MT1-MMP in oral squamous cell carcinoma as predictive indicator for tumor invasion and prognosis
Background: Squamous cell carcinoma of the oral cavity is a highly invasive neoplasm that spreads locally and metastasizes to regional lymph nodes. This process involves multiple proteolytic enzymes including matrilysin (MMP‐7) and membrane type I‐matrix metalloproteinase (MT1‐MMP). This study was...
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| Veröffentlicht in: | Journal of oral pathology & medicine 2007-08, Vol.36 (7), p.415-424 |
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| creator | De Vicente, J.-C. Lequerica-Fernández, P. Santamaría, J. Fresno, M.-F. |
| description | Background: Squamous cell carcinoma of the oral cavity is a highly invasive neoplasm that spreads locally and metastasizes to regional lymph nodes. This process involves multiple proteolytic enzymes including matrilysin (MMP‐7) and membrane type I‐matrix metalloproteinase (MT1‐MMP). This study was designed to explore the association between MMP‐7 and MT1‐MMP in the invasiveness and prognosis of oral squamous cell carcinoma (OSCC).
Methods: About 4‐μM, formalin‐fixed, paraffin‐embedded tissue sections from 69 patients with OSCC were immunohistochemically studied using specific antibodies against MMP‐7 and MT1‐MMP proteins. Immunostaining was semiquantitatively scored, and results were correlated with histologic and clinical variables including clinical behavior and survival.
Results: MMP‐7 was observed only in cancer cells, and MT1‐MMP in both tumoral tissue and stroma. MMP‐7 expression was significantly correlated with lymph node metastasis (P = 0.03; RR = 3.2). MT1‐MMP showed a significant association with TIMP‐2 (in N+ cases) and p53 expression (P = 0.01). MMP‐7 and MT1‐MMP displayed a survival relevance, and in multivariate analysis they were independent prognostic indicators, particularly in neck node‐positive cases. |
| doi_str_mv | 10.1111/j.1600-0714.2007.00546.x |
| format | Article |
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Methods: About 4‐μM, formalin‐fixed, paraffin‐embedded tissue sections from 69 patients with OSCC were immunohistochemically studied using specific antibodies against MMP‐7 and MT1‐MMP proteins. Immunostaining was semiquantitatively scored, and results were correlated with histologic and clinical variables including clinical behavior and survival.
Results: MMP‐7 was observed only in cancer cells, and MT1‐MMP in both tumoral tissue and stroma. MMP‐7 expression was significantly correlated with lymph node metastasis (P = 0.03; RR = 3.2). MT1‐MMP showed a significant association with TIMP‐2 (in N+ cases) and p53 expression (P = 0.01). MMP‐7 and MT1‐MMP displayed a survival relevance, and in multivariate analysis they were independent prognostic indicators, particularly in neck node‐positive cases.</description><identifier>ISSN: 0904-2512</identifier><identifier>EISSN: 1600-0714</identifier><identifier>DOI: 10.1111/j.1600-0714.2007.00546.x</identifier><identifier>PMID: 17617835</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Carcinoma, Squamous Cell - enzymology ; Carcinoma, Squamous Cell - pathology ; Carcinoma, Squamous Cell - secondary ; Cohort Studies ; Dentistry ; Female ; Forecasting ; Humans ; immunohistochemistry ; Lymphatic Metastasis - pathology ; Male ; Matrix Metalloproteinase 14 - analysis ; Matrix Metalloproteinase 2 - analysis ; Matrix Metalloproteinase 7 - analysis ; Matrix Metalloproteinase 9 - analysis ; membrane type I-matrix metalloproteinase ; Middle Aged ; MMP-7 ; Mouth Neoplasms - enzymology ; Mouth Neoplasms - pathology ; Neoplasm Invasiveness ; Neoplasm Staging ; oral squamous cell carcinoma ; Prognosis ; Retrospective Studies ; Survival Rate ; Tissue Inhibitor of Metalloproteinase-1 - analysis ; Tissue Inhibitor of Metalloproteinase-2 - analysis ; Tumor Suppressor Protein p53 - analysis</subject><ispartof>Journal of oral pathology & medicine, 2007-08, Vol.36 (7), p.415-424</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4706-41d718208998ccdfc03bc52afeae86cef8b4ac2eb022424fdde2641827c2970a3</citedby><cites>FETCH-LOGICAL-c4706-41d718208998ccdfc03bc52afeae86cef8b4ac2eb022424fdde2641827c2970a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1600-0714.2007.00546.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1600-0714.2007.00546.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17617835$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>De Vicente, J.-C.</creatorcontrib><creatorcontrib>Lequerica-Fernández, P.</creatorcontrib><creatorcontrib>Santamaría, J.</creatorcontrib><creatorcontrib>Fresno, M.-F.</creatorcontrib><title>Expression of MMP-7 and MT1-MMP in oral squamous cell carcinoma as predictive indicator for tumor invasion and prognosis</title><title>Journal of oral pathology & medicine</title><addtitle>J Oral Pathol Med</addtitle><description>Background: Squamous cell carcinoma of the oral cavity is a highly invasive neoplasm that spreads locally and metastasizes to regional lymph nodes. This process involves multiple proteolytic enzymes including matrilysin (MMP‐7) and membrane type I‐matrix metalloproteinase (MT1‐MMP). This study was designed to explore the association between MMP‐7 and MT1‐MMP in the invasiveness and prognosis of oral squamous cell carcinoma (OSCC).
Methods: About 4‐μM, formalin‐fixed, paraffin‐embedded tissue sections from 69 patients with OSCC were immunohistochemically studied using specific antibodies against MMP‐7 and MT1‐MMP proteins. Immunostaining was semiquantitatively scored, and results were correlated with histologic and clinical variables including clinical behavior and survival.
Results: MMP‐7 was observed only in cancer cells, and MT1‐MMP in both tumoral tissue and stroma. MMP‐7 expression was significantly correlated with lymph node metastasis (P = 0.03; RR = 3.2). MT1‐MMP showed a significant association with TIMP‐2 (in N+ cases) and p53 expression (P = 0.01). MMP‐7 and MT1‐MMP displayed a survival relevance, and in multivariate analysis they were independent prognostic indicators, particularly in neck node‐positive cases.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Carcinoma, Squamous Cell - enzymology</subject><subject>Carcinoma, Squamous Cell - pathology</subject><subject>Carcinoma, Squamous Cell - secondary</subject><subject>Cohort Studies</subject><subject>Dentistry</subject><subject>Female</subject><subject>Forecasting</subject><subject>Humans</subject><subject>immunohistochemistry</subject><subject>Lymphatic Metastasis - pathology</subject><subject>Male</subject><subject>Matrix Metalloproteinase 14 - analysis</subject><subject>Matrix Metalloproteinase 2 - analysis</subject><subject>Matrix Metalloproteinase 7 - analysis</subject><subject>Matrix Metalloproteinase 9 - analysis</subject><subject>membrane type I-matrix metalloproteinase</subject><subject>Middle Aged</subject><subject>MMP-7</subject><subject>Mouth Neoplasms - enzymology</subject><subject>Mouth Neoplasms - pathology</subject><subject>Neoplasm Invasiveness</subject><subject>Neoplasm Staging</subject><subject>oral squamous cell carcinoma</subject><subject>Prognosis</subject><subject>Retrospective Studies</subject><subject>Survival Rate</subject><subject>Tissue Inhibitor of Metalloproteinase-1 - analysis</subject><subject>Tissue Inhibitor of Metalloproteinase-2 - analysis</subject><subject>Tumor Suppressor Protein p53 - analysis</subject><issn>0904-2512</issn><issn>1600-0714</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkEtPxCAUhYnR6Pj4C4aVu9YLpYUmbozxmRmdRI1LwlBqGPsYodX676XORLeSABc459zwIYQJxCSM02VMMoAIOGExBeAxQMqyeNhCk9-HbTSBHFhEU0L30L73SwDCE0Z20R7hGeEiSSdouBxWznhv2wa3JZ7N5hHHqinw7IlE4YRtuHeqwv69V3Xbe6xNVWGtnLZNWyusPA4BhdWd_TBBHSrVtQ6XYXZ9HVbbfKif_DF25drXpvXWH6KdUlXeHG32A_R8dfl0cRNNH65vL86nkWYcsoiRghNBQeS50LooNSQLnVJVGmVEpk0pFkxpahZAKaOsLApDMxYcXNOcg0oO0Mk6N3R-743vZG39-AfVmPAdyYGPWPIgFGuhdq33zpRy5Wyt3JckIEfqcilHuHKEK0fq8oe6HIL1eNOjX9Sm-DNuMAfB2VrwaSvz9e9gefcwD0WwR2u79Z0Zfu3KvcmMJzyVL_fXUkzhcX4vUjlLvgGeH6Ap</recordid><startdate>200708</startdate><enddate>200708</enddate><creator>De Vicente, J.-C.</creator><creator>Lequerica-Fernández, P.</creator><creator>Santamaría, J.</creator><creator>Fresno, M.-F.</creator><general>Blackwell Publishing Ltd</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200708</creationdate><title>Expression of MMP-7 and MT1-MMP in oral squamous cell carcinoma as predictive indicator for tumor invasion and prognosis</title><author>De Vicente, J.-C. ; Lequerica-Fernández, P. ; Santamaría, J. ; Fresno, M.-F.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4706-41d718208998ccdfc03bc52afeae86cef8b4ac2eb022424fdde2641827c2970a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Carcinoma, Squamous Cell - enzymology</topic><topic>Carcinoma, Squamous Cell - pathology</topic><topic>Carcinoma, Squamous Cell - secondary</topic><topic>Cohort Studies</topic><topic>Dentistry</topic><topic>Female</topic><topic>Forecasting</topic><topic>Humans</topic><topic>immunohistochemistry</topic><topic>Lymphatic Metastasis - pathology</topic><topic>Male</topic><topic>Matrix Metalloproteinase 14 - analysis</topic><topic>Matrix Metalloproteinase 2 - analysis</topic><topic>Matrix Metalloproteinase 7 - analysis</topic><topic>Matrix Metalloproteinase 9 - analysis</topic><topic>membrane type I-matrix metalloproteinase</topic><topic>Middle Aged</topic><topic>MMP-7</topic><topic>Mouth Neoplasms - enzymology</topic><topic>Mouth Neoplasms - pathology</topic><topic>Neoplasm Invasiveness</topic><topic>Neoplasm Staging</topic><topic>oral squamous cell carcinoma</topic><topic>Prognosis</topic><topic>Retrospective Studies</topic><topic>Survival Rate</topic><topic>Tissue Inhibitor of Metalloproteinase-1 - analysis</topic><topic>Tissue Inhibitor of Metalloproteinase-2 - analysis</topic><topic>Tumor Suppressor Protein p53 - analysis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>De Vicente, J.-C.</creatorcontrib><creatorcontrib>Lequerica-Fernández, P.</creatorcontrib><creatorcontrib>Santamaría, J.</creatorcontrib><creatorcontrib>Fresno, M.-F.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of oral pathology & medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>De Vicente, J.-C.</au><au>Lequerica-Fernández, P.</au><au>Santamaría, J.</au><au>Fresno, M.-F.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Expression of MMP-7 and MT1-MMP in oral squamous cell carcinoma as predictive indicator for tumor invasion and prognosis</atitle><jtitle>Journal of oral pathology & medicine</jtitle><addtitle>J Oral Pathol Med</addtitle><date>2007-08</date><risdate>2007</risdate><volume>36</volume><issue>7</issue><spage>415</spage><epage>424</epage><pages>415-424</pages><issn>0904-2512</issn><eissn>1600-0714</eissn><abstract>Background: Squamous cell carcinoma of the oral cavity is a highly invasive neoplasm that spreads locally and metastasizes to regional lymph nodes. This process involves multiple proteolytic enzymes including matrilysin (MMP‐7) and membrane type I‐matrix metalloproteinase (MT1‐MMP). This study was designed to explore the association between MMP‐7 and MT1‐MMP in the invasiveness and prognosis of oral squamous cell carcinoma (OSCC).
Methods: About 4‐μM, formalin‐fixed, paraffin‐embedded tissue sections from 69 patients with OSCC were immunohistochemically studied using specific antibodies against MMP‐7 and MT1‐MMP proteins. Immunostaining was semiquantitatively scored, and results were correlated with histologic and clinical variables including clinical behavior and survival.
Results: MMP‐7 was observed only in cancer cells, and MT1‐MMP in both tumoral tissue and stroma. MMP‐7 expression was significantly correlated with lymph node metastasis (P = 0.03; RR = 3.2). MT1‐MMP showed a significant association with TIMP‐2 (in N+ cases) and p53 expression (P = 0.01). MMP‐7 and MT1‐MMP displayed a survival relevance, and in multivariate analysis they were independent prognostic indicators, particularly in neck node‐positive cases.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>17617835</pmid><doi>10.1111/j.1600-0714.2007.00546.x</doi><tpages>10</tpages></addata></record> |
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| subjects | Adult Aged Aged, 80 and over Carcinoma, Squamous Cell - enzymology Carcinoma, Squamous Cell - pathology Carcinoma, Squamous Cell - secondary Cohort Studies Dentistry Female Forecasting Humans immunohistochemistry Lymphatic Metastasis - pathology Male Matrix Metalloproteinase 14 - analysis Matrix Metalloproteinase 2 - analysis Matrix Metalloproteinase 7 - analysis Matrix Metalloproteinase 9 - analysis membrane type I-matrix metalloproteinase Middle Aged MMP-7 Mouth Neoplasms - enzymology Mouth Neoplasms - pathology Neoplasm Invasiveness Neoplasm Staging oral squamous cell carcinoma Prognosis Retrospective Studies Survival Rate Tissue Inhibitor of Metalloproteinase-1 - analysis Tissue Inhibitor of Metalloproteinase-2 - analysis Tumor Suppressor Protein p53 - analysis |
| title | Expression of MMP-7 and MT1-MMP in oral squamous cell carcinoma as predictive indicator for tumor invasion and prognosis |
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