Inhibition of malignant activities of nasopharyngeal carcinoma cells with high expression of CD44 by siRNA

Since CD44 was found to be significantly inhibited in the human nasopharyngeal carcinoma cell line CNE-2L2 with profound reduction of malignant activities caused by inhibition of alpha-mannosidase Man2c1 gene expression and CD44 has been observed to be involved in many tumor-supporting functions, we...

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Veröffentlicht in:	Oncology reports 2007-08, Vol.18 (2), p.397-403
Hauptverfasser:	SHI, Y, TIAN, Y, ZHOU, Y. Q, JU, J. Y, QU, L, CHEN, S. L, XIANG, Z. G, LIU, Y, ZHU, L. P
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenoviridae - genetics Animals Biological and medical sciences Blotting, Western Cadherins - metabolism Cell Line, Tumor Cell Proliferation Flow Cytometry G1 Phase - genetics G1 Phase - physiology Gene Expression Regulation, Neoplastic Genetic Therapy - methods Genetic Vectors - genetics Humans Hyaluronan Receptors - genetics Hyaluronan Receptors - metabolism Medical sciences Mice Mice, Nude Nasopharyngeal Neoplasms - genetics Nasopharyngeal Neoplasms - pathology Nasopharyngeal Neoplasms - therapy Neoplasm Metastasis Otorhinolaryngology. Stomatology Reverse Transcriptase Polymerase Chain Reaction RNA Interference RNA, Small Interfering - genetics Transfection Tumors Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology Xenograft Model Antitumor Assays - methods
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