Pretty Subunits All in a Row: Using Concatenated Subunit Constructs to Force the Expression of Receptors with Defined Subunit Stoichiometry and Spatial Arrangement

The members of the Cys-loop ligand-gated ion channel (LGIC) gene family play a major role in fast synaptic transmission, and these receptors represent an important class of targets for therapeutic agents. Each member of this gene family is a pentameric complex containing one or more different subuni...

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Veröffentlicht in:	Molecular pharmacology 2006-02, Vol.69 (2), p.407-410
1. Verfasser:	White, Michael M
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cysteine - chemistry Humans Ion Channel Gating Protein Conformation Protein Subunits - chemistry Protein Subunits - genetics Protein Subunits - metabolism Receptors, Neurotransmitter - chemistry Receptors, Neurotransmitter - genetics Receptors, Neurotransmitter - metabolism
Online-Zugang:	Volltext
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