Plasma Glutathione and Cystathionine Concentrations Are Elevated but Cysteine Flux Is Unchanged by Dietary Vitamin B-6 Restriction in Young Men and Women

Cysteine synthesis from homocysteine is catalyzed by two pyridoxal 5'-phosphate (PLP)-dependent enzymes. This suggests that vitamin B-6 status might affect cysteine and glutathione homeostasis, but it is unclear whether this occurs in humans. We assessed the effects of vitamin B-6 status on sta...

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Veröffentlicht in:	The Journal of nutrition 2006-02, Vol.136 (2), p.373-378
Hauptverfasser:	Davis, Steven R, Quinlivan, Eoin P, Stacpoole, Peter W, Gregory, Jesse F
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aging - blood Amino Acids - blood Biological and medical sciences blood plasma C-reactive protein cystathionine Cystathionine - blood cysteine Cysteine - blood cysteinylglycine Diet Feeding. Feeding behavior Female Fundamental and applied biological sciences. Psychology glutathione Glutathione - blood homeostasis human nutrition Humans inflammation Male men metabolism methionine nutritional status Peptides - blood pyridoxine serine transsulfuration Vertebrates: anatomy and physiology, studies on body, several organs or systems Vitamin B 6 - administration & dosage Vitamin B 6 - pharmacology vitamin deficiencies women young adults
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Zusammenfassung:	Cysteine synthesis from homocysteine is catalyzed by two pyridoxal 5'-phosphate (PLP)-dependent enzymes. This suggests that vitamin B-6 status might affect cysteine and glutathione homeostasis, but it is unclear whether this occurs in humans. We assessed the effects of vitamin B-6 status on static and kinetic parameters of cysteine and glutathione metabolism in healthy female (n = 5) and male (n = 4) volunteers (20-30 y) before and after 4 wk of dietary vitamin B-6 restriction (
ISSN:	0022-3166 1541-6100
DOI:	10.1093/jn/136.2.373