Activating Transcription Factor 6 Polymorphisms and Haplotypes Are Associated with Impaired Glucose Homeostasis and Type 2 Diabetes in Dutch Caucasians

Context: Activating transcription factor 6 (ATF6) is critical for initiation and full activation of the unfolded protein response. An association between genetic variation in ATF6 and type 2 diabetes (DM2) was recently reported in Pima Indians. Objectives: To investigate the broader significance of...

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Veröffentlicht in:	The journal of clinical endocrinology and metabolism 2007-07, Vol.92 (7), p.2720-2725
Hauptverfasser:	Meex, Steven J. R., van Greevenbroek, Marleen M. J., Ayoubi, Torik A., Vlietinck, Robert, van Vliet-Ostaptchouk, Jana V., Hofker, Martin H., Vermeulen, Vicky M. M.-J., Schalkwijk, Casper G., Feskens, Edith J. M., Boer, Jolanda M. A., Stehouwer, Coen D. A., van der Kallen, Carla J. H., de Bruin, Tjerk W. A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Activating Transcription Factor 6 - genetics Aged Biological and medical sciences Blood Glucose Diabetes Mellitus, Type 2 - ethnology Diabetes Mellitus, Type 2 - genetics Diabetes Mellitus, Type 2 - metabolism European Continental Ancestry Group - genetics European Continental Ancestry Group - statistics & numerical data Fasting Feeding. Feeding behavior Female Fundamental and applied biological sciences. Psychology Gene Frequency Genetic Predisposition to Disease Glucose Intolerance - ethnology Glucose Intolerance - genetics Glucose Intolerance - metabolism Haplotypes Homeostasis - genetics Humans Male Middle Aged Netherlands - epidemiology Polymorphism, Genetic Vertebrates: anatomy and physiology, studies on body, several organs or systems Vertebrates: endocrinology
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