Immune cells contribute to the maintenance of neurogenesis and spatial learning abilities in adulthood

Neurogenesis is known to take place in the adult brain. This work identifies T lymphocytes and microglia as being important to the maintenance of hippocampal neurogenesis and spatial learning abilities in adulthood. Hippocampal neurogenesis induced by an enriched environment was associated with the...

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Veröffentlicht in:	Nature neuroscience 2006-02, Vol.9 (2), p.268-275
Hauptverfasser:	Ziv, Yaniv, Ron, Noga, Butovsky, Oleg, Landa, Gennady, Sudai, Einav, Greenberg, Nadav, Cohen, Hagit, Kipnis, Jonathan, Schwartz, Michal
Format:	Artikel
Sprache:	eng
Schlagworte:	Adults Animal Genetics and Genomics Animals Antigens Behavioral Sciences Biological Techniques Biomedical and Life Sciences Biomedicine Brain-Derived Neurotrophic Factor Care and treatment Cell Division - physiology Cognitive learning Hippocampus - cytology Hippocampus - immunology Hippocampus - physiology Immunohistochemistry Influence Lymphocytes Male Maze Learning - physiology Memory - physiology Microglia - physiology Neurobiology Neurogenesis Neuronal Plasticity - physiology Neurosciences Physiological aspects Rats Rats, Sprague-Dawley Spatial Behavior - physiology Stem Cells - cytology Stem Cells - physiology T cells T-Lymphocytes - physiology
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