The Effect of Bacille Calmette-Guérin Vaccine Strain and Route of Administration on Induced Immune Responses in Vaccinated Infants
Vaccination with Mycobacterium bovis bacille Calmette-Guérin (BCG) has variable efficacy in preventing tuberculosis. Both BCG strain and route of administration have been implicated in determining efficacy; however, these variables are not considered in current clinical recommendations for vaccine c...
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| Veröffentlicht in: | The Journal of infectious diseases 2006-02, Vol.193 (4), p.531-536 |
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| creator | Davids, Virginia Hanekom, Willem A. Mansoor, Nazma Gamieldien, Hoyam Sebastian, J. Gelderbloem Hawkridge, Anthony Hussey, Gregory D. Hughes, E. Jane Soler, Jorge Murray, Rose Ann Ress, Stanley R. Kaplan, Gilla |
| description | Vaccination with Mycobacterium bovis bacille Calmette-Guérin (BCG) has variable efficacy in preventing tuberculosis. Both BCG strain and route of administration have been implicated in determining efficacy; however, these variables are not considered in current clinical recommendations for vaccine choice. We evaluated antigen-specific immunity after percutaneous or intradermal administration of Japanese BCG or intradermal administration of Danish BCG. Ten weeks after vaccination of neonates, percutaneous Japanese BCG had induced significantly higher frequencies of BCG-specific interferon-γ-producing CD4+ and CD8+ T cells in BCG-stimulated whole blood than did intradermal Danish BCG. Similarly, percutaneous vaccination with Japanese BCG resulted in significantly greater secretion of the T helper 1-type cytokines interferon-γ, tumor necrosis factor-α, and interleukin-2; significantly lower secretion of the T helper 2-type cytokine interleukin-4; and greater CD4+ and CD8+ T cell proliferation. Thus, BCG strain and route of neonatal vaccination confer different levels of immune activation, which may affect the efficacy of the vaccine. |
| doi_str_mv | 10.1086/499825 |
| format | Article |
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Ten weeks after vaccination of neonates, percutaneous Japanese BCG had induced significantly higher frequencies of BCG-specific interferon-γ-producing CD4+ and CD8+ T cells in BCG-stimulated whole blood than did intradermal Danish BCG. Similarly, percutaneous vaccination with Japanese BCG resulted in significantly greater secretion of the T helper 1-type cytokines interferon-γ, tumor necrosis factor-α, and interleukin-2; significantly lower secretion of the T helper 2-type cytokine interleukin-4; and greater CD4+ and CD8+ T cell proliferation. Thus, BCG strain and route of neonatal vaccination confer different levels of immune activation, which may affect the efficacy of the vaccine.</description><identifier>ISSN: 0022-1899</identifier><identifier>EISSN: 1537-6613</identifier><identifier>DOI: 10.1086/499825</identifier><identifier>PMID: 16425132</identifier><identifier>CODEN: JIDIAQ</identifier><language>eng</language><publisher>Chicago, IL: The University of Chicago Press</publisher><subject>Antibodies, Bacterial - blood ; Applied microbiology ; Bacillus calmette guerin vaccine ; Bacteria ; BCG Vaccine - administration & dosage ; BCG Vaccine - immunology ; BCG Vaccine - pharmacology ; Biological and medical sciences ; Blood ; Cytokines ; Drug Administration Routes ; Evaluation Studies as Topic ; Female ; Fundamental and applied biological sciences. Psychology ; Health care administration ; Humans ; Immunity ; Immunity - drug effects ; Infant ; Infant, Newborn - immunology ; Infectious diseases ; Male ; Medical sciences ; Microbiology ; Mycobacterium bovis ; Mycobacterium tuberculosis ; T lymphocytes ; T-Lymphocytes, Cytotoxic - drug effects ; T-Lymphocytes, Cytotoxic - immunology ; Tuberculin ; Tuberculosis vaccine ; Vaccination ; Vaccination - methods ; Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects)</subject><ispartof>The Journal of infectious diseases, 2006-02, Vol.193 (4), p.531-536</ispartof><rights>2006 by the Infectious Diseases Society of America 2006</rights><rights>2007 INIST-CNRS</rights><rights>Copyright University of Chicago Press Feb 15, 2006</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c549t-d91cd3b9a230b0c0bdd3c0b5a6537d61c402e19b883b001991167d8ff81112aa3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/30087605$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/30087605$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>315,782,786,805,27931,27932,58024,58257</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=18764530$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16425132$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Davids, Virginia</creatorcontrib><creatorcontrib>Hanekom, Willem A.</creatorcontrib><creatorcontrib>Mansoor, Nazma</creatorcontrib><creatorcontrib>Gamieldien, Hoyam</creatorcontrib><creatorcontrib>Sebastian, J. Gelderbloem</creatorcontrib><creatorcontrib>Hawkridge, Anthony</creatorcontrib><creatorcontrib>Hussey, Gregory D.</creatorcontrib><creatorcontrib>Hughes, E. Jane</creatorcontrib><creatorcontrib>Soler, Jorge</creatorcontrib><creatorcontrib>Murray, Rose Ann</creatorcontrib><creatorcontrib>Ress, Stanley R.</creatorcontrib><creatorcontrib>Kaplan, Gilla</creatorcontrib><title>The Effect of Bacille Calmette-Guérin Vaccine Strain and Route of Administration on Induced Immune Responses in Vaccinated Infants</title><title>The Journal of infectious diseases</title><addtitle>J Infect Dis</addtitle><addtitle>J Infect Dis</addtitle><description>Vaccination with Mycobacterium bovis bacille Calmette-Guérin (BCG) has variable efficacy in preventing tuberculosis. Both BCG strain and route of administration have been implicated in determining efficacy; however, these variables are not considered in current clinical recommendations for vaccine choice. We evaluated antigen-specific immunity after percutaneous or intradermal administration of Japanese BCG or intradermal administration of Danish BCG. Ten weeks after vaccination of neonates, percutaneous Japanese BCG had induced significantly higher frequencies of BCG-specific interferon-γ-producing CD4+ and CD8+ T cells in BCG-stimulated whole blood than did intradermal Danish BCG. Similarly, percutaneous vaccination with Japanese BCG resulted in significantly greater secretion of the T helper 1-type cytokines interferon-γ, tumor necrosis factor-α, and interleukin-2; significantly lower secretion of the T helper 2-type cytokine interleukin-4; and greater CD4+ and CD8+ T cell proliferation. Thus, BCG strain and route of neonatal vaccination confer different levels of immune activation, which may affect the efficacy of the vaccine.</description><subject>Antibodies, Bacterial - blood</subject><subject>Applied microbiology</subject><subject>Bacillus calmette guerin vaccine</subject><subject>Bacteria</subject><subject>BCG Vaccine - administration & dosage</subject><subject>BCG Vaccine - immunology</subject><subject>BCG Vaccine - pharmacology</subject><subject>Biological and medical sciences</subject><subject>Blood</subject><subject>Cytokines</subject><subject>Drug Administration Routes</subject><subject>Evaluation Studies as Topic</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Health care administration</subject><subject>Humans</subject><subject>Immunity</subject><subject>Immunity - drug effects</subject><subject>Infant</subject><subject>Infant, Newborn - immunology</subject><subject>Infectious diseases</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Microbiology</subject><subject>Mycobacterium bovis</subject><subject>Mycobacterium tuberculosis</subject><subject>T lymphocytes</subject><subject>T-Lymphocytes, Cytotoxic - drug effects</subject><subject>T-Lymphocytes, Cytotoxic - immunology</subject><subject>Tuberculin</subject><subject>Tuberculosis vaccine</subject><subject>Vaccination</subject><subject>Vaccination - methods</subject><subject>Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects)</subject><issn>0022-1899</issn><issn>1537-6613</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkdFqFDEUhgdR7LbqGyixoHejJ8lMMrmsS20XK0pbdfEmZJIMzjqTrEkG9Nqn8Tl8MbPssguCCCHh8H_nP5z8RfEIwwsMDXtZCdGQ-k4xwzXlJWOY3i1mAISUuBHiqDiOcQUAFWX8fnGEWUVqTMms-Hn7xaLzrrM6Id-hV0r3w2DRXA2jTcmWF9PvX6F36KPSuncW3aSgcqmcQdd-SnbTdGbG3vUxK6n3DuWzcGbS1qDFOE656drGtXfRRrR3Umkju065FB8U9zo1RPtw954UH16f384vy6t3F4v52VWp60qk0gisDW2FIhRa0NAaQ_NdK5ZXNgzrCojFom0a2gJgITBm3DRd12CMiVL0pHi-9V0H_22yMcmxj9oOg3LWT1FyYPkTG_xfEHPgnAmewdO_wJWfgstLSEKogDyYH9x08DEG28l16EcVfkgMchOe3IaXwSc7t6kdrTlgu7Qy8GwHqKjV0AXldB8PXMNZVVPI3NMt56f1v4c93jKrmHzYUxQgu8BGL7d6DtZ-3-sqfJWMU17Ly-Vn-f7Tmxt4Wy3lkv4BJPnDRg</recordid><startdate>20060215</startdate><enddate>20060215</enddate><creator>Davids, Virginia</creator><creator>Hanekom, Willem A.</creator><creator>Mansoor, Nazma</creator><creator>Gamieldien, Hoyam</creator><creator>Sebastian, J. 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Gelderbloem</au><au>Hawkridge, Anthony</au><au>Hussey, Gregory D.</au><au>Hughes, E. Jane</au><au>Soler, Jorge</au><au>Murray, Rose Ann</au><au>Ress, Stanley R.</au><au>Kaplan, Gilla</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The Effect of Bacille Calmette-Guérin Vaccine Strain and Route of Administration on Induced Immune Responses in Vaccinated Infants</atitle><jtitle>The Journal of infectious diseases</jtitle><stitle>J Infect Dis</stitle><addtitle>J Infect Dis</addtitle><date>2006-02-15</date><risdate>2006</risdate><volume>193</volume><issue>4</issue><spage>531</spage><epage>536</epage><pages>531-536</pages><issn>0022-1899</issn><eissn>1537-6613</eissn><coden>JIDIAQ</coden><abstract>Vaccination with Mycobacterium bovis bacille Calmette-Guérin (BCG) has variable efficacy in preventing tuberculosis. Both BCG strain and route of administration have been implicated in determining efficacy; however, these variables are not considered in current clinical recommendations for vaccine choice. We evaluated antigen-specific immunity after percutaneous or intradermal administration of Japanese BCG or intradermal administration of Danish BCG. Ten weeks after vaccination of neonates, percutaneous Japanese BCG had induced significantly higher frequencies of BCG-specific interferon-γ-producing CD4+ and CD8+ T cells in BCG-stimulated whole blood than did intradermal Danish BCG. Similarly, percutaneous vaccination with Japanese BCG resulted in significantly greater secretion of the T helper 1-type cytokines interferon-γ, tumor necrosis factor-α, and interleukin-2; significantly lower secretion of the T helper 2-type cytokine interleukin-4; and greater CD4+ and CD8+ T cell proliferation. Thus, BCG strain and route of neonatal vaccination confer different levels of immune activation, which may affect the efficacy of the vaccine.</abstract><cop>Chicago, IL</cop><pub>The University of Chicago Press</pub><pmid>16425132</pmid><doi>10.1086/499825</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | The Journal of infectious diseases, 2006-02, Vol.193 (4), p.531-536 |
| issn | 0022-1899 1537-6613 |
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| source | MEDLINE; JSTOR Archive Collection A-Z Listing; Oxford University Press Journals All Titles (1996-Current); Alma/SFX Local Collection |
| subjects | Antibodies, Bacterial - blood Applied microbiology Bacillus calmette guerin vaccine Bacteria BCG Vaccine - administration & dosage BCG Vaccine - immunology BCG Vaccine - pharmacology Biological and medical sciences Blood Cytokines Drug Administration Routes Evaluation Studies as Topic Female Fundamental and applied biological sciences. Psychology Health care administration Humans Immunity Immunity - drug effects Infant Infant, Newborn - immunology Infectious diseases Male Medical sciences Microbiology Mycobacterium bovis Mycobacterium tuberculosis T lymphocytes T-Lymphocytes, Cytotoxic - drug effects T-Lymphocytes, Cytotoxic - immunology Tuberculin Tuberculosis vaccine Vaccination Vaccination - methods Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects) |
| title | The Effect of Bacille Calmette-Guérin Vaccine Strain and Route of Administration on Induced Immune Responses in Vaccinated Infants |
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