XLF Interacts with the XRCC4-DNA Ligase IV Complex to Promote DNA Nonhomologous End-Joining

DNA nonhomologous end-joining (NHEJ) is a predominant pathway of DNA double-strand break repair in mammalian cells, and defects in it cause radiosensitivity at the cellular and whole-organism levels. Central to NHEJ is the protein complex containing DNA Ligase IV and XRCC4. By searching for addition...

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Veröffentlicht in:	Cell 2006-01, Vol.124 (2), p.301-313
Hauptverfasser:	Ahnesorg, Peter, Smith, Philippa, Jackson, Stephen P.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals Cell Line Consensus Sequence DNA Ligase ATP DNA Ligases - metabolism DNA Repair DNA Repair Enzymes DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism Down-Regulation Humans Molecular Sequence Data Mutation Nuclear Proteins - genetics Nuclear Proteins - metabolism Radiation Tolerance Sequence Alignment
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