Food-protein enzymatic hydrolysates possess both antimicrobial and immunostimulatory activities: a ‘cause and effect’ theory of bifunctionality
Abstract The antimicrobial activity (the ability to activate the microbial autolytic system) and immunostimulatory activity (the ability to improve the phagocytic cell functioning) of 20 food-protein hydrolysates [five food proteins (casein, α-lactalbumin, β-lactoglobulin, ovalbumin and serum albumi...
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| Veröffentlicht in: | FEMS immunology and medical microbiology 2006-02, Vol.46 (1), p.131-138 |
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| creator | Biziulevičius, Gediminas A. Kislukhina, Olga V. Kazlauskaitė, Jurgita Žukaitė, Vilhelmina |
| description | Abstract
The antimicrobial activity (the ability to activate the microbial autolytic system) and immunostimulatory activity (the ability to improve the phagocytic cell functioning) of 20 food-protein hydrolysates [five food proteins (casein, α-lactalbumin, β-lactoglobulin, ovalbumin and serum albumin) hydrolyzed with four gastrointestinal proteinases (trypsin, α-chymotrypsin, pepsin and pancreatin)] were examined. All the food-protein hydrolysates acted antimicrobially in vitro towards all 24 microbial strains tested: autolysis of 20 naturally autolyzing strains was activated, with the autolysis activation index (KA) ranging from 1.04 to 22.0, while autolysis was induced to values of 2.81–56.7% in four naturally nonautolyzing strains. When given to mice per os, all the food-protein hydrolysates enhanced the phagocytosing capacity of peritoneal macrophages, with the enhancement index (KI) ranging from 1.02 to 1.41. A direct correlation between KA and KI was observed. We make the presumption that KI is a function of KA. |
| doi_str_mv | 10.1111/j.1574-695X.2005.00019.x |
| format | Article |
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The antimicrobial activity (the ability to activate the microbial autolytic system) and immunostimulatory activity (the ability to improve the phagocytic cell functioning) of 20 food-protein hydrolysates [five food proteins (casein, α-lactalbumin, β-lactoglobulin, ovalbumin and serum albumin) hydrolyzed with four gastrointestinal proteinases (trypsin, α-chymotrypsin, pepsin and pancreatin)] were examined. All the food-protein hydrolysates acted antimicrobially in vitro towards all 24 microbial strains tested: autolysis of 20 naturally autolyzing strains was activated, with the autolysis activation index (KA) ranging from 1.04 to 22.0, while autolysis was induced to values of 2.81–56.7% in four naturally nonautolyzing strains. When given to mice per os, all the food-protein hydrolysates enhanced the phagocytosing capacity of peritoneal macrophages, with the enhancement index (KI) ranging from 1.02 to 1.41. A direct correlation between KA and KI was observed. We make the presumption that KI is a function of KA.</description><identifier>ISSN: 0928-8244</identifier><identifier>EISSN: 1574-695X</identifier><identifier>EISSN: 2049-632X</identifier><identifier>DOI: 10.1111/j.1574-695X.2005.00019.x</identifier><identifier>PMID: 16420606</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>a ‘cause and effect’ theory of bifunctionality ; Adjuvants, Immunologic - chemistry ; Adjuvants, Immunologic - pharmacology ; Animals ; Anti-Infective Agents - chemistry ; Anti-Infective Agents - pharmacology ; Antiinfectives and antibacterials ; Antimicrobial activity ; Antimicrobial agents ; Autolysis ; Bacteria - drug effects ; Casein ; Chymotrypsin ; Dietary Proteins - metabolism ; Dietary Proteins - pharmacology ; Female ; Food ; food‐protein hydrolysates ; Fungi - drug effects ; Gastrointestinal Tract - enzymology ; Hydrolysates ; Hydrolysis ; Immunostimulation ; immunostimulatory activity ; Lactalbumin ; Lactoglobulin ; macrophage phagocytosing capacity ; Macrophages ; Macrophages, Peritoneal - drug effects ; Male ; Mice ; Mice, Inbred BALB C ; microbial autolytic system ; Microorganisms ; Models, Biological ; Ovalbumin ; Pancreatin ; Pepsin ; Peptide Hydrolases - chemistry ; Peritoneum ; Phagocytes ; Phagocytosis - drug effects ; Protein Hydrolysates - chemistry ; Protein Hydrolysates - pharmacology ; Proteins ; Serum albumin ; Trypsin ; β-Lactoglobulin</subject><ispartof>FEMS immunology and medical microbiology, 2006-02, Vol.46 (1), p.131-138</ispartof><rights>2005 Federation of European Microbiological Societies 2005</rights><rights>2005 Federation of European Microbiological Societies</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1574-695X.2005.00019.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16420606$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Biziulevičius, Gediminas A.</creatorcontrib><creatorcontrib>Kislukhina, Olga V.</creatorcontrib><creatorcontrib>Kazlauskaitė, Jurgita</creatorcontrib><creatorcontrib>Žukaitė, Vilhelmina</creatorcontrib><title>Food-protein enzymatic hydrolysates possess both antimicrobial and immunostimulatory activities: a ‘cause and effect’ theory of bifunctionality</title><title>FEMS immunology and medical microbiology</title><addtitle>FEMS Immunol Med Microbiol</addtitle><description>Abstract
The antimicrobial activity (the ability to activate the microbial autolytic system) and immunostimulatory activity (the ability to improve the phagocytic cell functioning) of 20 food-protein hydrolysates [five food proteins (casein, α-lactalbumin, β-lactoglobulin, ovalbumin and serum albumin) hydrolyzed with four gastrointestinal proteinases (trypsin, α-chymotrypsin, pepsin and pancreatin)] were examined. All the food-protein hydrolysates acted antimicrobially in vitro towards all 24 microbial strains tested: autolysis of 20 naturally autolyzing strains was activated, with the autolysis activation index (KA) ranging from 1.04 to 22.0, while autolysis was induced to values of 2.81–56.7% in four naturally nonautolyzing strains. When given to mice per os, all the food-protein hydrolysates enhanced the phagocytosing capacity of peritoneal macrophages, with the enhancement index (KI) ranging from 1.02 to 1.41. A direct correlation between KA and KI was observed. We make the presumption that KI is a function of KA.</description><subject>a ‘cause and effect’ theory of bifunctionality</subject><subject>Adjuvants, Immunologic - chemistry</subject><subject>Adjuvants, Immunologic - pharmacology</subject><subject>Animals</subject><subject>Anti-Infective Agents - chemistry</subject><subject>Anti-Infective Agents - pharmacology</subject><subject>Antiinfectives and antibacterials</subject><subject>Antimicrobial activity</subject><subject>Antimicrobial agents</subject><subject>Autolysis</subject><subject>Bacteria - drug effects</subject><subject>Casein</subject><subject>Chymotrypsin</subject><subject>Dietary Proteins - metabolism</subject><subject>Dietary Proteins - pharmacology</subject><subject>Female</subject><subject>Food</subject><subject>food‐protein hydrolysates</subject><subject>Fungi - drug effects</subject><subject>Gastrointestinal Tract - enzymology</subject><subject>Hydrolysates</subject><subject>Hydrolysis</subject><subject>Immunostimulation</subject><subject>immunostimulatory activity</subject><subject>Lactalbumin</subject><subject>Lactoglobulin</subject><subject>macrophage phagocytosing capacity</subject><subject>Macrophages</subject><subject>Macrophages, Peritoneal - drug effects</subject><subject>Male</subject><subject>Mice</subject><subject>Mice, Inbred BALB C</subject><subject>microbial autolytic system</subject><subject>Microorganisms</subject><subject>Models, Biological</subject><subject>Ovalbumin</subject><subject>Pancreatin</subject><subject>Pepsin</subject><subject>Peptide Hydrolases - chemistry</subject><subject>Peritoneum</subject><subject>Phagocytes</subject><subject>Phagocytosis - drug effects</subject><subject>Protein Hydrolysates - chemistry</subject><subject>Protein Hydrolysates - pharmacology</subject><subject>Proteins</subject><subject>Serum albumin</subject><subject>Trypsin</subject><subject>β-Lactoglobulin</subject><issn>0928-8244</issn><issn>1574-695X</issn><issn>2049-632X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kc-K1TAUh4MoznX0FSQguGtNm6RpxI0MXh0YcaPgLpymCTeXtrk2iU5dzTu40debJzGdOyooZpM_5_sOSX4I4YqUVR7P9mXFBSsayT-WNSG8JIRUsry8gza_C3fRhsi6LdqasRP0IIR9hpgk5D46qRpWk4Y0G_Rt631fHGYfjZuwmb4uI0Sn8W7pZz8sAaIJ-OBDMCHgzscdhim60enZdw6GvOuxG8c0-ZCP0wDRzwsGHd1nF50JzzHg66vvGlIwN7Cx1uh4ffUDx51ZWW9x52yasuInGFxcHqJ7FoZgHt3Op-jD9tX7szfFxbvX52cvLwpPKZOF5GA1ADG2pbUUYI0AwXgDVS8Y7a1pNOcSeAvcQt11vdattJSSTlPa65aeoqfHvvn5n5IJUY0uaDMMMBmfghKkkUK0LINP_gL3Ps35skHVlIiKV5TLTD2-pVI3ml4dZjfCvKhfn52BF0fgixvM8qdO1Bqq2qs1O7Vmp9ZQ1U2o6lJtz9_mRdbpUffp8B-5-EemPwFmyqsl</recordid><startdate>20060201</startdate><enddate>20060201</enddate><creator>Biziulevičius, Gediminas A.</creator><creator>Kislukhina, Olga V.</creator><creator>Kazlauskaitė, Jurgita</creator><creator>Žukaitė, Vilhelmina</creator><general>Blackwell Publishing Ltd</general><general>Oxford University Press</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7T7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>K9.</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>20060201</creationdate><title>Food-protein enzymatic hydrolysates possess both antimicrobial and immunostimulatory activities: a ‘cause and effect’ theory of bifunctionality</title><author>Biziulevičius, Gediminas A. ; Kislukhina, Olga V. ; Kazlauskaitė, Jurgita ; Žukaitė, Vilhelmina</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-o3349-95afcaa0ef83297afe7a7456a1d743dfe6c559a58a5fa2bbdcc89f330bc33dc83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>a ‘cause and effect’ theory of bifunctionality</topic><topic>Adjuvants, Immunologic - chemistry</topic><topic>Adjuvants, Immunologic - pharmacology</topic><topic>Animals</topic><topic>Anti-Infective Agents - chemistry</topic><topic>Anti-Infective Agents - pharmacology</topic><topic>Antiinfectives and antibacterials</topic><topic>Antimicrobial activity</topic><topic>Antimicrobial agents</topic><topic>Autolysis</topic><topic>Bacteria - drug effects</topic><topic>Casein</topic><topic>Chymotrypsin</topic><topic>Dietary Proteins - metabolism</topic><topic>Dietary Proteins - pharmacology</topic><topic>Female</topic><topic>Food</topic><topic>food‐protein hydrolysates</topic><topic>Fungi - drug effects</topic><topic>Gastrointestinal Tract - enzymology</topic><topic>Hydrolysates</topic><topic>Hydrolysis</topic><topic>Immunostimulation</topic><topic>immunostimulatory activity</topic><topic>Lactalbumin</topic><topic>Lactoglobulin</topic><topic>macrophage phagocytosing capacity</topic><topic>Macrophages</topic><topic>Macrophages, Peritoneal - drug effects</topic><topic>Male</topic><topic>Mice</topic><topic>Mice, Inbred BALB C</topic><topic>microbial autolytic system</topic><topic>Microorganisms</topic><topic>Models, Biological</topic><topic>Ovalbumin</topic><topic>Pancreatin</topic><topic>Pepsin</topic><topic>Peptide Hydrolases - chemistry</topic><topic>Peritoneum</topic><topic>Phagocytes</topic><topic>Phagocytosis - drug effects</topic><topic>Protein Hydrolysates - chemistry</topic><topic>Protein Hydrolysates - pharmacology</topic><topic>Proteins</topic><topic>Serum albumin</topic><topic>Trypsin</topic><topic>β-Lactoglobulin</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Biziulevičius, Gediminas A.</creatorcontrib><creatorcontrib>Kislukhina, Olga V.</creatorcontrib><creatorcontrib>Kazlauskaitė, Jurgita</creatorcontrib><creatorcontrib>Žukaitė, Vilhelmina</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>FEMS immunology and medical microbiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Biziulevičius, Gediminas A.</au><au>Kislukhina, Olga V.</au><au>Kazlauskaitė, Jurgita</au><au>Žukaitė, Vilhelmina</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Food-protein enzymatic hydrolysates possess both antimicrobial and immunostimulatory activities: a ‘cause and effect’ theory of bifunctionality</atitle><jtitle>FEMS immunology and medical microbiology</jtitle><addtitle>FEMS Immunol Med Microbiol</addtitle><date>2006-02-01</date><risdate>2006</risdate><volume>46</volume><issue>1</issue><spage>131</spage><epage>138</epage><pages>131-138</pages><issn>0928-8244</issn><eissn>1574-695X</eissn><eissn>2049-632X</eissn><abstract>Abstract
The antimicrobial activity (the ability to activate the microbial autolytic system) and immunostimulatory activity (the ability to improve the phagocytic cell functioning) of 20 food-protein hydrolysates [five food proteins (casein, α-lactalbumin, β-lactoglobulin, ovalbumin and serum albumin) hydrolyzed with four gastrointestinal proteinases (trypsin, α-chymotrypsin, pepsin and pancreatin)] were examined. All the food-protein hydrolysates acted antimicrobially in vitro towards all 24 microbial strains tested: autolysis of 20 naturally autolyzing strains was activated, with the autolysis activation index (KA) ranging from 1.04 to 22.0, while autolysis was induced to values of 2.81–56.7% in four naturally nonautolyzing strains. When given to mice per os, all the food-protein hydrolysates enhanced the phagocytosing capacity of peritoneal macrophages, with the enhancement index (KI) ranging from 1.02 to 1.41. A direct correlation between KA and KI was observed. We make the presumption that KI is a function of KA.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>16420606</pmid><doi>10.1111/j.1574-695X.2005.00019.x</doi><tpages>8</tpages></addata></record> |
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| ispartof | FEMS immunology and medical microbiology, 2006-02, Vol.46 (1), p.131-138 |
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| subjects | a ‘cause and effect’ theory of bifunctionality Adjuvants, Immunologic - chemistry Adjuvants, Immunologic - pharmacology Animals Anti-Infective Agents - chemistry Anti-Infective Agents - pharmacology Antiinfectives and antibacterials Antimicrobial activity Antimicrobial agents Autolysis Bacteria - drug effects Casein Chymotrypsin Dietary Proteins - metabolism Dietary Proteins - pharmacology Female Food food‐protein hydrolysates Fungi - drug effects Gastrointestinal Tract - enzymology Hydrolysates Hydrolysis Immunostimulation immunostimulatory activity Lactalbumin Lactoglobulin macrophage phagocytosing capacity Macrophages Macrophages, Peritoneal - drug effects Male Mice Mice, Inbred BALB C microbial autolytic system Microorganisms Models, Biological Ovalbumin Pancreatin Pepsin Peptide Hydrolases - chemistry Peritoneum Phagocytes Phagocytosis - drug effects Protein Hydrolysates - chemistry Protein Hydrolysates - pharmacology Proteins Serum albumin Trypsin β-Lactoglobulin |
| title | Food-protein enzymatic hydrolysates possess both antimicrobial and immunostimulatory activities: a ‘cause and effect’ theory of bifunctionality |
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