Testicular injury to rats fed on soybean [Glycine max] protein-based vitamin B12-deficient diet can be reduced by methionine supplementation
We have previously reported that rats fed on a vitamin Bsub(12) (Bsub(12))-deficient diet containing 180 g soybean protein per kg diet showed marked histologic damage in their testes. In this paper, we report the effect of Bsub(12)-deficiency on Bsub(12)-dependent methionine synthase in the rats...
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| creator | Yamada, K.(Okayama Univ. (Japan). Faculty of Engineering) Kawata, T Wada, M Mori, K Tamai, H Tanaka, N Tadokoro, T Tobimatsu, T Toraya, T Maekawa, A |
| description | We have previously reported that rats fed on a vitamin Bsub(12) (Bsub(12))-deficient diet containing 180 g soybean protein per kg diet showed marked histologic damage in their testes. In this paper, we report the effect of Bsub(12)-deficiency on Bsub(12)-dependent methionine synthase in the rats' testes and the effect of methionine supplementation of the diet on testicular damage. Rats were fed the soybean protein-based Bsub(12)-deficient diet for 120 d. We confirmed that those rats were in serious Bsub(12)-deficiency by measuring urinary methylmalonic acid excretion and Bsub(12) content in tissues. Methionine synthase activity in the testis of the Bsub(12)-deficient rats was less than 2% of that in Bsub(12)-supplemented (control) rats. To complement disrupted methionine biosynthesis, methionine was supplied in the diet. A supplement of 5 g D,L-methionine per kg diet to the Bsub(12)-deficient diet did not affect urinary methylmalonic acid excretion of Bsub(12)-deficient rats. The testicular histology of rats fed the methionine-supplemented Bsub(12)-deficient diet was almost indistinguishable from that of control rats. Thus, we conclude that the lowered testicular methionine synthase activity is the primary cause of the histologic damage due to Bsub(12)-deficiency and that methionine supplementation to the diet can reduce the damage. These findings would indicate the importance of the methionine synthase activity, especially for testicular function. |
| doi_str_mv | 10.3177/jnsv.53.95 |
| format | Article |
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(Japan). Faculty of Engineering) ; Kawata, T ; Wada, M ; Mori, K ; Tamai, H ; Tanaka, N ; Tadokoro, T ; Tobimatsu, T ; Toraya, T ; Maekawa, A</creator><creatorcontrib>Yamada, K.(Okayama Univ. (Japan). Faculty of Engineering) ; Kawata, T ; Wada, M ; Mori, K ; Tamai, H ; Tanaka, N ; Tadokoro, T ; Tobimatsu, T ; Toraya, T ; Maekawa, A</creatorcontrib><description>We have previously reported that rats fed on a vitamin Bsub(12) (Bsub(12))-deficient diet containing 180 g soybean protein per kg diet showed marked histologic damage in their testes. In this paper, we report the effect of Bsub(12)-deficiency on Bsub(12)-dependent methionine synthase in the rats' testes and the effect of methionine supplementation of the diet on testicular damage. Rats were fed the soybean protein-based Bsub(12)-deficient diet for 120 d. We confirmed that those rats were in serious Bsub(12)-deficiency by measuring urinary methylmalonic acid excretion and Bsub(12) content in tissues. Methionine synthase activity in the testis of the Bsub(12)-deficient rats was less than 2% of that in Bsub(12)-supplemented (control) rats. To complement disrupted methionine biosynthesis, methionine was supplied in the diet. A supplement of 5 g D,L-methionine per kg diet to the Bsub(12)-deficient diet did not affect urinary methylmalonic acid excretion of Bsub(12)-deficient rats. The testicular histology of rats fed the methionine-supplemented Bsub(12)-deficient diet was almost indistinguishable from that of control rats. Thus, we conclude that the lowered testicular methionine synthase activity is the primary cause of the histologic damage due to Bsub(12)-deficiency and that methionine supplementation to the diet can reduce the damage. These findings would indicate the importance of the methionine synthase activity, especially for testicular function.</description><identifier>ISSN: 0301-4800</identifier><identifier>EISSN: 1881-7742</identifier><identifier>DOI: 10.3177/jnsv.53.95</identifier><identifier>PMID: 17615995</identifier><language>eng</language><publisher>Tokyo: Center for Academic Publications Japan</publisher><subject>5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase - biosynthesis ; 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase - drug effects ; Analysis of Variance ; Animals ; Biological and medical sciences ; Body Weight - drug effects ; CARENCE EN VITAMINE ; COMPLEMENT ALIMENTAIRE ; DAMAGE ; DANOS ; DEFICIENCIA DE VITAMINAS ; DEGAT ; DIET ; Diet - methods ; DIETA ; Dietary Supplements ; Disease Models, Animal ; Feeding. Feeding behavior ; Female ; Fundamental and applied biological sciences. Psychology ; LIASAS ; LYASE ; LYASES ; Male ; METHIONINE ; Methionine - therapeutic use ; methionine synthase ; Methylmalonic Acid - urine ; METIONINA ; Organ Size - drug effects ; PROTEINAS ; PROTEINE ; PROTEINS ; rat ; Rats ; Rats, Wistar ; REGIME ALIMENTAIRE ; SOJA ; Soybean Proteins - administration & dosage ; SOYBEANS ; SUPLEMENTOS ; SUPPLEMENTS ; TESTES ; Testicular Diseases - complications ; Testicular Diseases - pathology ; Testicular Diseases - prevention & control ; TESTICULE ; TESTICULOS ; testis ; Testis - drug effects ; Testis - physiopathology ; Testis - ultrastructure ; Vertebrates: anatomy and physiology, studies on body, several organs or systems ; Vitamin B 12 Deficiency - complications ; Vitamin B 12 Deficiency - diet therapy ; Vitamin B 12 Deficiency - urine ; VITAMIN B12 ; vitamin B12-deficiency ; VITAMIN DEFICIENCIES ; VITAMINA B12 ; VITAMINE B12</subject><ispartof>Journal of Nutritional Science and Vitaminology, 2007, Vol.53(2), pp.95-101</ispartof><rights>2007 by the Center for Academic Publications Japan</rights><rights>2007 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c2985-190b0b45d9dfc4f249edcf3c82c2e2d1ecbedfb50b3d464a47f1093213979c283</citedby><cites>FETCH-LOGICAL-c2985-190b0b45d9dfc4f249edcf3c82c2e2d1ecbedfb50b3d464a47f1093213979c283</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,1876,27903,27904</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=18856807$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17615995$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yamada, K.(Okayama Univ. (Japan). Faculty of Engineering)</creatorcontrib><creatorcontrib>Kawata, T</creatorcontrib><creatorcontrib>Wada, M</creatorcontrib><creatorcontrib>Mori, K</creatorcontrib><creatorcontrib>Tamai, H</creatorcontrib><creatorcontrib>Tanaka, N</creatorcontrib><creatorcontrib>Tadokoro, T</creatorcontrib><creatorcontrib>Tobimatsu, T</creatorcontrib><creatorcontrib>Toraya, T</creatorcontrib><creatorcontrib>Maekawa, A</creatorcontrib><title>Testicular injury to rats fed on soybean [Glycine max] protein-based vitamin B12-deficient diet can be reduced by methionine supplementation</title><title>Journal of Nutritional Science and Vitaminology</title><addtitle>J Nutr Sci Vitaminol</addtitle><description>We have previously reported that rats fed on a vitamin Bsub(12) (Bsub(12))-deficient diet containing 180 g soybean protein per kg diet showed marked histologic damage in their testes. In this paper, we report the effect of Bsub(12)-deficiency on Bsub(12)-dependent methionine synthase in the rats' testes and the effect of methionine supplementation of the diet on testicular damage. Rats were fed the soybean protein-based Bsub(12)-deficient diet for 120 d. We confirmed that those rats were in serious Bsub(12)-deficiency by measuring urinary methylmalonic acid excretion and Bsub(12) content in tissues. Methionine synthase activity in the testis of the Bsub(12)-deficient rats was less than 2% of that in Bsub(12)-supplemented (control) rats. To complement disrupted methionine biosynthesis, methionine was supplied in the diet. A supplement of 5 g D,L-methionine per kg diet to the Bsub(12)-deficient diet did not affect urinary methylmalonic acid excretion of Bsub(12)-deficient rats. The testicular histology of rats fed the methionine-supplemented Bsub(12)-deficient diet was almost indistinguishable from that of control rats. Thus, we conclude that the lowered testicular methionine synthase activity is the primary cause of the histologic damage due to Bsub(12)-deficiency and that methionine supplementation to the diet can reduce the damage. These findings would indicate the importance of the methionine synthase activity, especially for testicular function.</description><subject>5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase - biosynthesis</subject><subject>5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase - drug effects</subject><subject>Analysis of Variance</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Body Weight - drug effects</subject><subject>CARENCE EN VITAMINE</subject><subject>COMPLEMENT ALIMENTAIRE</subject><subject>DAMAGE</subject><subject>DANOS</subject><subject>DEFICIENCIA DE VITAMINAS</subject><subject>DEGAT</subject><subject>DIET</subject><subject>Diet - methods</subject><subject>DIETA</subject><subject>Dietary Supplements</subject><subject>Disease Models, Animal</subject><subject>Feeding. Feeding behavior</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>LIASAS</subject><subject>LYASE</subject><subject>LYASES</subject><subject>Male</subject><subject>METHIONINE</subject><subject>Methionine - therapeutic use</subject><subject>methionine synthase</subject><subject>Methylmalonic Acid - urine</subject><subject>METIONINA</subject><subject>Organ Size - drug effects</subject><subject>PROTEINAS</subject><subject>PROTEINE</subject><subject>PROTEINS</subject><subject>rat</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>REGIME ALIMENTAIRE</subject><subject>SOJA</subject><subject>Soybean Proteins - administration & dosage</subject><subject>SOYBEANS</subject><subject>SUPLEMENTOS</subject><subject>SUPPLEMENTS</subject><subject>TESTES</subject><subject>Testicular Diseases - complications</subject><subject>Testicular Diseases - pathology</subject><subject>Testicular Diseases - prevention & control</subject><subject>TESTICULE</subject><subject>TESTICULOS</subject><subject>testis</subject><subject>Testis - drug effects</subject><subject>Testis - physiopathology</subject><subject>Testis - ultrastructure</subject><subject>Vertebrates: anatomy and physiology, studies on body, several organs or systems</subject><subject>Vitamin B 12 Deficiency - complications</subject><subject>Vitamin B 12 Deficiency - diet therapy</subject><subject>Vitamin B 12 Deficiency - urine</subject><subject>VITAMIN B12</subject><subject>vitamin B12-deficiency</subject><subject>VITAMIN DEFICIENCIES</subject><subject>VITAMINA B12</subject><subject>VITAMINE B12</subject><issn>0301-4800</issn><issn>1881-7742</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpF0U1vFCEYB_CJ0di1evGu4aIHk1mBgQVORhutmiZ6qCdjCC8PLZsZZgszjfMd_NCy2c02IZDAjz_w0DQvCV53RIj321Tu17xbK_6oWREpSSsEo4-bFe4waZnE-Kx5VsoWY6Ykk0-bMyI2hCvFV82_ayhTdHNvMoppO-cFTSPKZioogEdjQmVcLJiEfl_2i4sJ0GD-_kG7PE4QU2tNqew-TmaICX0itPUQoouQJuQjTMjVrRZQBj-7Ku2CBphu45j2UWXe7XoYKjZTnXrePAmmL_DiOJ43v758vr742l79uPx28fGqdVRJ3hKFLbaMe-WDY4EyBd6FzknqKFBPwFnwwXJsO882zDARCFYdJZ0SylHZnTdvD7n1FXdzLYAeYnHQ9ybBOBct8EYJxnGF7w7Q5bGUDEHvchxMXjTBel97va-95p1WvOLXx9TZDuAf6LHYFbw5AlOc6UM2ycXy4KTkG4lFdR8OblsmcwMnYHL9qR5OZ9JDp_hpxd2arCHVhFeHhGBGbW5yPeX7T4qxqK1eu_sP6fevkA</recordid><startdate>200704</startdate><enddate>200704</enddate><creator>Yamada, K.(Okayama Univ. (Japan). Faculty of Engineering)</creator><creator>Kawata, T</creator><creator>Wada, M</creator><creator>Mori, K</creator><creator>Tamai, H</creator><creator>Tanaka, N</creator><creator>Tadokoro, T</creator><creator>Tobimatsu, T</creator><creator>Toraya, T</creator><creator>Maekawa, A</creator><general>Center for Academic Publications Japan</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200704</creationdate><title>Testicular injury to rats fed on soybean [Glycine max] protein-based vitamin B12-deficient diet can be reduced by methionine supplementation</title><author>Yamada, K.(Okayama Univ. (Japan). Faculty of Engineering) ; Kawata, T ; Wada, M ; Mori, K ; Tamai, H ; Tanaka, N ; Tadokoro, T ; Tobimatsu, T ; Toraya, T ; Maekawa, A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c2985-190b0b45d9dfc4f249edcf3c82c2e2d1ecbedfb50b3d464a47f1093213979c283</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase - biosynthesis</topic><topic>5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase - drug effects</topic><topic>Analysis of Variance</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Body Weight - drug effects</topic><topic>CARENCE EN VITAMINE</topic><topic>COMPLEMENT ALIMENTAIRE</topic><topic>DAMAGE</topic><topic>DANOS</topic><topic>DEFICIENCIA DE VITAMINAS</topic><topic>DEGAT</topic><topic>DIET</topic><topic>Diet - methods</topic><topic>DIETA</topic><topic>Dietary Supplements</topic><topic>Disease Models, Animal</topic><topic>Feeding. Feeding behavior</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>LIASAS</topic><topic>LYASE</topic><topic>LYASES</topic><topic>Male</topic><topic>METHIONINE</topic><topic>Methionine - therapeutic use</topic><topic>methionine synthase</topic><topic>Methylmalonic Acid - urine</topic><topic>METIONINA</topic><topic>Organ Size - drug effects</topic><topic>PROTEINAS</topic><topic>PROTEINE</topic><topic>PROTEINS</topic><topic>rat</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>REGIME ALIMENTAIRE</topic><topic>SOJA</topic><topic>Soybean Proteins - administration & dosage</topic><topic>SOYBEANS</topic><topic>SUPLEMENTOS</topic><topic>SUPPLEMENTS</topic><topic>TESTES</topic><topic>Testicular Diseases - complications</topic><topic>Testicular Diseases - pathology</topic><topic>Testicular Diseases - prevention & control</topic><topic>TESTICULE</topic><topic>TESTICULOS</topic><topic>testis</topic><topic>Testis - drug effects</topic><topic>Testis - physiopathology</topic><topic>Testis - ultrastructure</topic><topic>Vertebrates: anatomy and physiology, studies on body, several organs or systems</topic><topic>Vitamin B 12 Deficiency - complications</topic><topic>Vitamin B 12 Deficiency - diet therapy</topic><topic>Vitamin B 12 Deficiency - urine</topic><topic>VITAMIN B12</topic><topic>vitamin B12-deficiency</topic><topic>VITAMIN DEFICIENCIES</topic><topic>VITAMINA B12</topic><topic>VITAMINE B12</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yamada, K.(Okayama Univ. (Japan). Faculty of Engineering)</creatorcontrib><creatorcontrib>Kawata, T</creatorcontrib><creatorcontrib>Wada, M</creatorcontrib><creatorcontrib>Mori, K</creatorcontrib><creatorcontrib>Tamai, H</creatorcontrib><creatorcontrib>Tanaka, N</creatorcontrib><creatorcontrib>Tadokoro, T</creatorcontrib><creatorcontrib>Tobimatsu, T</creatorcontrib><creatorcontrib>Toraya, T</creatorcontrib><creatorcontrib>Maekawa, A</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of Nutritional Science and Vitaminology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yamada, K.(Okayama Univ. (Japan). Faculty of Engineering)</au><au>Kawata, T</au><au>Wada, M</au><au>Mori, K</au><au>Tamai, H</au><au>Tanaka, N</au><au>Tadokoro, T</au><au>Tobimatsu, T</au><au>Toraya, T</au><au>Maekawa, A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Testicular injury to rats fed on soybean [Glycine max] protein-based vitamin B12-deficient diet can be reduced by methionine supplementation</atitle><jtitle>Journal of Nutritional Science and Vitaminology</jtitle><addtitle>J Nutr Sci Vitaminol</addtitle><date>2007-04</date><risdate>2007</risdate><volume>53</volume><issue>2</issue><spage>95</spage><epage>101</epage><pages>95-101</pages><issn>0301-4800</issn><eissn>1881-7742</eissn><abstract>We have previously reported that rats fed on a vitamin Bsub(12) (Bsub(12))-deficient diet containing 180 g soybean protein per kg diet showed marked histologic damage in their testes. In this paper, we report the effect of Bsub(12)-deficiency on Bsub(12)-dependent methionine synthase in the rats' testes and the effect of methionine supplementation of the diet on testicular damage. Rats were fed the soybean protein-based Bsub(12)-deficient diet for 120 d. We confirmed that those rats were in serious Bsub(12)-deficiency by measuring urinary methylmalonic acid excretion and Bsub(12) content in tissues. Methionine synthase activity in the testis of the Bsub(12)-deficient rats was less than 2% of that in Bsub(12)-supplemented (control) rats. To complement disrupted methionine biosynthesis, methionine was supplied in the diet. A supplement of 5 g D,L-methionine per kg diet to the Bsub(12)-deficient diet did not affect urinary methylmalonic acid excretion of Bsub(12)-deficient rats. The testicular histology of rats fed the methionine-supplemented Bsub(12)-deficient diet was almost indistinguishable from that of control rats. Thus, we conclude that the lowered testicular methionine synthase activity is the primary cause of the histologic damage due to Bsub(12)-deficiency and that methionine supplementation to the diet can reduce the damage. These findings would indicate the importance of the methionine synthase activity, especially for testicular function.</abstract><cop>Tokyo</cop><pub>Center for Academic Publications Japan</pub><pmid>17615995</pmid><doi>10.3177/jnsv.53.95</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Journal of Nutritional Science and Vitaminology, 2007, Vol.53(2), pp.95-101 |
| issn | 0301-4800 1881-7742 |
| language | eng |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; J-STAGE (Japan Science & Technology Information Aggregator, Electronic) Freely Available Titles - Japanese |
| subjects | 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase - biosynthesis 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase - drug effects Analysis of Variance Animals Biological and medical sciences Body Weight - drug effects CARENCE EN VITAMINE COMPLEMENT ALIMENTAIRE DAMAGE DANOS DEFICIENCIA DE VITAMINAS DEGAT DIET Diet - methods DIETA Dietary Supplements Disease Models, Animal Feeding. Feeding behavior Female Fundamental and applied biological sciences. Psychology LIASAS LYASE LYASES Male METHIONINE Methionine - therapeutic use methionine synthase Methylmalonic Acid - urine METIONINA Organ Size - drug effects PROTEINAS PROTEINE PROTEINS rat Rats Rats, Wistar REGIME ALIMENTAIRE SOJA Soybean Proteins - administration & dosage SOYBEANS SUPLEMENTOS SUPPLEMENTS TESTES Testicular Diseases - complications Testicular Diseases - pathology Testicular Diseases - prevention & control TESTICULE TESTICULOS testis Testis - drug effects Testis - physiopathology Testis - ultrastructure Vertebrates: anatomy and physiology, studies on body, several organs or systems Vitamin B 12 Deficiency - complications Vitamin B 12 Deficiency - diet therapy Vitamin B 12 Deficiency - urine VITAMIN B12 vitamin B12-deficiency VITAMIN DEFICIENCIES VITAMINA B12 VITAMINE B12 |
| title | Testicular injury to rats fed on soybean [Glycine max] protein-based vitamin B12-deficient diet can be reduced by methionine supplementation |
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