Matrix metalloproteinase-8 and -9 are increased at the site of abdominal aortic aneurysm rupture
Abdominal aortic aneurysm (AAA) expansion is characterized by extracellular matrix degradation and widespread inflammation. In contrast, the processes that characterize AAA rupture are not well understood. The aim of this study was to investigate the proteolytic and cellular activity of ruptured AAA...
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| Veröffentlicht in: | Circulation (New York, N.Y.) N.Y.), 2006-01, Vol.113 (3), p.438-445 |
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| container_title | Circulation (New York, N.Y.) |
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| creator | WILSON, W. Richard W ANDERTON, Marcus SCHWALBE, Edward C JONES, J. Louise FURNESS, Peter N BELL, Peter R. F THOMPSON, Matthew M |
| description | Abdominal aortic aneurysm (AAA) expansion is characterized by extracellular matrix degradation and widespread inflammation. In contrast, the processes that characterize AAA rupture are not well understood. The aim of this study was to investigate the proteolytic and cellular activity of ruptured AAA, focusing on matrix metalloproteinases (MMPs) and their inhibitors (TIMPs).
Anterior aneurysm wall biopsies were taken from 55 nonruptured and 21 ruptured AAAs. A further biopsy from the site of rupture was taken from 12 of the ruptured AAAs. MMP-1, -2, -3, -8, -9, and -13, as well as TIMP-1 and -2, were quantified in each biopsy with ELISA. A comparison of anterior aneurysm biopsies showed no difference in MMP or TIMP concentrations between nonruptured and ruptured AAA. In a comparison of ruptured AAA biopsies, MMP-8 and -9 levels were significantly elevated in the 12 rupture site biopsies compared with their 12 paired anterior wall biopsies, whereas other MMPs and TIMPs showed no difference (MMP-8, P |
| doi_str_mv | 10.1161/CIRCULATIONAHA.105.551572 |
| format | Article |
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Anterior aneurysm wall biopsies were taken from 55 nonruptured and 21 ruptured AAAs. A further biopsy from the site of rupture was taken from 12 of the ruptured AAAs. MMP-1, -2, -3, -8, -9, and -13, as well as TIMP-1 and -2, were quantified in each biopsy with ELISA. A comparison of anterior aneurysm biopsies showed no difference in MMP or TIMP concentrations between nonruptured and ruptured AAA. In a comparison of ruptured AAA biopsies, MMP-8 and -9 levels were significantly elevated in the 12 rupture site biopsies compared with their 12 paired anterior wall biopsies, whereas other MMPs and TIMPs showed no difference (MMP-8, P<0.001; MMP-9, P=0.01). MMP-8 and -9 expression was mediated by native mesenchymal cells and was independent of the inflammatory infiltrate.
A localized increase in MMP-8 and -9, mediated by native mesenchymal cells, presents a potential pathway for collagen breakdown and AAA rupture.</description><identifier>ISSN: 0009-7322</identifier><identifier>EISSN: 1524-4539</identifier><identifier>DOI: 10.1161/CIRCULATIONAHA.105.551572</identifier><identifier>PMID: 16432074</identifier><identifier>CODEN: CIRCAZ</identifier><language>eng</language><publisher>Hagerstown, MD: Lippincott Williams & Wilkins</publisher><subject>Aged ; Aorta, Abdominal - enzymology ; Aorta, Abdominal - pathology ; Aortic Aneurysm, Abdominal - metabolism ; Aortic Aneurysm, Abdominal - pathology ; Aortic Rupture - metabolism ; Aortic Rupture - pathology ; Biological and medical sciences ; Biopsy ; Blood and lymphatic vessels ; Cardiology. Vascular system ; Cardiovascular system ; Collagen - metabolism ; Diseases of the aorta ; Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous ; Female ; Gene Expression Regulation, Enzymologic ; Humans ; Investigative techniques, diagnostic techniques (general aspects) ; Male ; Matrix Metalloproteinase 8 - genetics ; Matrix Metalloproteinase 8 - metabolism ; Matrix Metalloproteinase 9 - genetics ; Matrix Metalloproteinase 9 - metabolism ; Medical sciences ; Mesoderm - enzymology ; Mesoderm - pathology ; Radiodiagnosis. Nmr imagery. Nmr spectrometry ; Vasculitis - metabolism ; Vasculitis - pathology</subject><ispartof>Circulation (New York, N.Y.), 2006-01, Vol.113 (3), p.438-445</ispartof><rights>2006 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c503t-422265c754af611745f4034842264b93047e2350197751e0b0517e44eb1353513</citedby><cites>FETCH-LOGICAL-c503t-422265c754af611745f4034842264b93047e2350197751e0b0517e44eb1353513</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,3687,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=17467501$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16432074$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>WILSON, W. Richard W</creatorcontrib><creatorcontrib>ANDERTON, Marcus</creatorcontrib><creatorcontrib>SCHWALBE, Edward C</creatorcontrib><creatorcontrib>JONES, J. Louise</creatorcontrib><creatorcontrib>FURNESS, Peter N</creatorcontrib><creatorcontrib>BELL, Peter R. F</creatorcontrib><creatorcontrib>THOMPSON, Matthew M</creatorcontrib><title>Matrix metalloproteinase-8 and -9 are increased at the site of abdominal aortic aneurysm rupture</title><title>Circulation (New York, N.Y.)</title><addtitle>Circulation</addtitle><description>Abdominal aortic aneurysm (AAA) expansion is characterized by extracellular matrix degradation and widespread inflammation. In contrast, the processes that characterize AAA rupture are not well understood. The aim of this study was to investigate the proteolytic and cellular activity of ruptured AAA, focusing on matrix metalloproteinases (MMPs) and their inhibitors (TIMPs).
Anterior aneurysm wall biopsies were taken from 55 nonruptured and 21 ruptured AAAs. A further biopsy from the site of rupture was taken from 12 of the ruptured AAAs. MMP-1, -2, -3, -8, -9, and -13, as well as TIMP-1 and -2, were quantified in each biopsy with ELISA. A comparison of anterior aneurysm biopsies showed no difference in MMP or TIMP concentrations between nonruptured and ruptured AAA. In a comparison of ruptured AAA biopsies, MMP-8 and -9 levels were significantly elevated in the 12 rupture site biopsies compared with their 12 paired anterior wall biopsies, whereas other MMPs and TIMPs showed no difference (MMP-8, P<0.001; MMP-9, P=0.01). MMP-8 and -9 expression was mediated by native mesenchymal cells and was independent of the inflammatory infiltrate.
A localized increase in MMP-8 and -9, mediated by native mesenchymal cells, presents a potential pathway for collagen breakdown and AAA rupture.</description><subject>Aged</subject><subject>Aorta, Abdominal - enzymology</subject><subject>Aorta, Abdominal - pathology</subject><subject>Aortic Aneurysm, Abdominal - metabolism</subject><subject>Aortic Aneurysm, Abdominal - pathology</subject><subject>Aortic Rupture - metabolism</subject><subject>Aortic Rupture - pathology</subject><subject>Biological and medical sciences</subject><subject>Biopsy</subject><subject>Blood and lymphatic vessels</subject><subject>Cardiology. Vascular system</subject><subject>Cardiovascular system</subject><subject>Collagen - metabolism</subject><subject>Diseases of the aorta</subject><subject>Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous</subject><subject>Female</subject><subject>Gene Expression Regulation, Enzymologic</subject><subject>Humans</subject><subject>Investigative techniques, diagnostic techniques (general aspects)</subject><subject>Male</subject><subject>Matrix Metalloproteinase 8 - genetics</subject><subject>Matrix Metalloproteinase 8 - metabolism</subject><subject>Matrix Metalloproteinase 9 - genetics</subject><subject>Matrix Metalloproteinase 9 - metabolism</subject><subject>Medical sciences</subject><subject>Mesoderm - enzymology</subject><subject>Mesoderm - pathology</subject><subject>Radiodiagnosis. Nmr imagery. Nmr spectrometry</subject><subject>Vasculitis - metabolism</subject><subject>Vasculitis - pathology</subject><issn>0009-7322</issn><issn>1524-4539</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkFtLAzEQhYMoWqt_QeKDvm3NJJmN-1iK2kK1IPq8ZrezuLKXmmTB_nsjLRSfhjl8Zy6HsWsQE4AU7maL19n7cvq2WL1M59MJCJwgAhp5xEaAUicaVXbMRkKILDFKyjN27v1XbFNl8JSdQaqVFEaP2MezDa7-4S0F2zT9xvWB6s56Su657dY8ybh1xOuudBTVNbeBh0_ivg7E-4rbYt230dBw27tQl9FEg9v6lrthEwZHF-ykso2ny30ds_fHh7fZPFmunhaz6TIpUaiQaClliqVBbasUwGistFD6PuqpLjIltCGpUEBmDAKJQiAY0poKUKgQ1Jjd7ubGF74H8iFva19S08SD-sHnRqSZAWkimO3A0vXeO6ryjatb67Y5iPwv3vx_vFHGfBdv9F7tlwxFS-uDc59nBG72gPWlbSpnu7L2B87o1MQn1C_JB4KJ</recordid><startdate>20060124</startdate><enddate>20060124</enddate><creator>WILSON, W. Richard W</creator><creator>ANDERTON, Marcus</creator><creator>SCHWALBE, Edward C</creator><creator>JONES, J. Louise</creator><creator>FURNESS, Peter N</creator><creator>BELL, Peter R. F</creator><creator>THOMPSON, Matthew M</creator><general>Lippincott Williams & Wilkins</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20060124</creationdate><title>Matrix metalloproteinase-8 and -9 are increased at the site of abdominal aortic aneurysm rupture</title><author>WILSON, W. Richard W ; ANDERTON, Marcus ; SCHWALBE, Edward C ; JONES, J. Louise ; FURNESS, Peter N ; BELL, Peter R. F ; THOMPSON, Matthew M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c503t-422265c754af611745f4034842264b93047e2350197751e0b0517e44eb1353513</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Aged</topic><topic>Aorta, Abdominal - enzymology</topic><topic>Aorta, Abdominal - pathology</topic><topic>Aortic Aneurysm, Abdominal - metabolism</topic><topic>Aortic Aneurysm, Abdominal - pathology</topic><topic>Aortic Rupture - metabolism</topic><topic>Aortic Rupture - pathology</topic><topic>Biological and medical sciences</topic><topic>Biopsy</topic><topic>Blood and lymphatic vessels</topic><topic>Cardiology. Vascular system</topic><topic>Cardiovascular system</topic><topic>Collagen - metabolism</topic><topic>Diseases of the aorta</topic><topic>Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous</topic><topic>Female</topic><topic>Gene Expression Regulation, Enzymologic</topic><topic>Humans</topic><topic>Investigative techniques, diagnostic techniques (general aspects)</topic><topic>Male</topic><topic>Matrix Metalloproteinase 8 - genetics</topic><topic>Matrix Metalloproteinase 8 - metabolism</topic><topic>Matrix Metalloproteinase 9 - genetics</topic><topic>Matrix Metalloproteinase 9 - metabolism</topic><topic>Medical sciences</topic><topic>Mesoderm - enzymology</topic><topic>Mesoderm - pathology</topic><topic>Radiodiagnosis. Nmr imagery. Nmr spectrometry</topic><topic>Vasculitis - metabolism</topic><topic>Vasculitis - pathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>WILSON, W. Richard W</creatorcontrib><creatorcontrib>ANDERTON, Marcus</creatorcontrib><creatorcontrib>SCHWALBE, Edward C</creatorcontrib><creatorcontrib>JONES, J. Louise</creatorcontrib><creatorcontrib>FURNESS, Peter N</creatorcontrib><creatorcontrib>BELL, Peter R. F</creatorcontrib><creatorcontrib>THOMPSON, Matthew M</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Circulation (New York, N.Y.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>WILSON, W. Richard W</au><au>ANDERTON, Marcus</au><au>SCHWALBE, Edward C</au><au>JONES, J. Louise</au><au>FURNESS, Peter N</au><au>BELL, Peter R. F</au><au>THOMPSON, Matthew M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Matrix metalloproteinase-8 and -9 are increased at the site of abdominal aortic aneurysm rupture</atitle><jtitle>Circulation (New York, N.Y.)</jtitle><addtitle>Circulation</addtitle><date>2006-01-24</date><risdate>2006</risdate><volume>113</volume><issue>3</issue><spage>438</spage><epage>445</epage><pages>438-445</pages><issn>0009-7322</issn><eissn>1524-4539</eissn><coden>CIRCAZ</coden><abstract>Abdominal aortic aneurysm (AAA) expansion is characterized by extracellular matrix degradation and widespread inflammation. In contrast, the processes that characterize AAA rupture are not well understood. The aim of this study was to investigate the proteolytic and cellular activity of ruptured AAA, focusing on matrix metalloproteinases (MMPs) and their inhibitors (TIMPs).
Anterior aneurysm wall biopsies were taken from 55 nonruptured and 21 ruptured AAAs. A further biopsy from the site of rupture was taken from 12 of the ruptured AAAs. MMP-1, -2, -3, -8, -9, and -13, as well as TIMP-1 and -2, were quantified in each biopsy with ELISA. A comparison of anterior aneurysm biopsies showed no difference in MMP or TIMP concentrations between nonruptured and ruptured AAA. In a comparison of ruptured AAA biopsies, MMP-8 and -9 levels were significantly elevated in the 12 rupture site biopsies compared with their 12 paired anterior wall biopsies, whereas other MMPs and TIMPs showed no difference (MMP-8, P<0.001; MMP-9, P=0.01). MMP-8 and -9 expression was mediated by native mesenchymal cells and was independent of the inflammatory infiltrate.
A localized increase in MMP-8 and -9, mediated by native mesenchymal cells, presents a potential pathway for collagen breakdown and AAA rupture.</abstract><cop>Hagerstown, MD</cop><pub>Lippincott Williams & Wilkins</pub><pmid>16432074</pmid><doi>10.1161/CIRCULATIONAHA.105.551572</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; American Heart Association Journals; Journals@Ovid Complete; EZB-FREE-00999 freely available EZB journals |
| subjects | Aged Aorta, Abdominal - enzymology Aorta, Abdominal - pathology Aortic Aneurysm, Abdominal - metabolism Aortic Aneurysm, Abdominal - pathology Aortic Rupture - metabolism Aortic Rupture - pathology Biological and medical sciences Biopsy Blood and lymphatic vessels Cardiology. Vascular system Cardiovascular system Collagen - metabolism Diseases of the aorta Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous Female Gene Expression Regulation, Enzymologic Humans Investigative techniques, diagnostic techniques (general aspects) Male Matrix Metalloproteinase 8 - genetics Matrix Metalloproteinase 8 - metabolism Matrix Metalloproteinase 9 - genetics Matrix Metalloproteinase 9 - metabolism Medical sciences Mesoderm - enzymology Mesoderm - pathology Radiodiagnosis. Nmr imagery. Nmr spectrometry Vasculitis - metabolism Vasculitis - pathology |
| title | Matrix metalloproteinase-8 and -9 are increased at the site of abdominal aortic aneurysm rupture |
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