Serum Retinol-Binding Protein Is More Highly Expressed in Visceral than in Subcutaneous Adipose Tissue and Is a Marker of Intra-abdominal Fat Mass
Intra-abdominal fat is associated with insulin resistance and cardiovascular risk. Levels of serum retinol-binding protein (RBP4), secreted by fat and liver cells, are increased in obesity and type 2 diabetes (T2D). Here we report that, in 196 subjects, RBP4 is preferentially expressed in visceral (...
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| Veröffentlicht in: | Cell metabolism 2007-07, Vol.6 (1), p.79-87 |
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| creator | Klöting, Nora Graham, Timothy E. Berndt, Janin Kralisch, Susan Kovacs, Peter Wason, Christopher J. Fasshauer, Mathias Schön, Michael R. Stumvoll, Michael Blüher, Matthias Kahn, Barbara B. |
| description | Intra-abdominal fat is associated with insulin resistance and cardiovascular risk. Levels of serum retinol-binding protein (RBP4), secreted by fat and liver cells, are increased in obesity and type 2 diabetes (T2D). Here we report that, in 196 subjects, RBP4 is preferentially expressed in visceral (Vis) versus subcutaneous (SC) fat. Vis fat
RBP4 mRNA was increased ∼60-fold and 12-fold in Vis and SC obese subjects respectively versus lean subjects, and ∼2-fold with impaired glucose tolerance/T2D subjects versus normoglycemic subjects. In obese subjects, serum RBP4 was increased 2- to 3-fold, and serum transthyretin, which stabilizes RBP4 in the circulation, was increased 35%. Serum RBP4 correlated positively with adipose
RBP4 mRNA and intra-abdominal fat mass and inversely with insulin sensitivity, independently of age, gender, and body mass index.
RBP4 mRNA correlated inversely with
GLUT4 mRNA in Vis fat and positively with adipocyte size in both depots. RBP4 levels are therefore linked to Vis adiposity, and Vis fat may be a major source of RBP4 in insulin-resistant states. |
| doi_str_mv | 10.1016/j.cmet.2007.06.002 |
| format | Article |
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RBP4 mRNA was increased ∼60-fold and 12-fold in Vis and SC obese subjects respectively versus lean subjects, and ∼2-fold with impaired glucose tolerance/T2D subjects versus normoglycemic subjects. In obese subjects, serum RBP4 was increased 2- to 3-fold, and serum transthyretin, which stabilizes RBP4 in the circulation, was increased 35%. Serum RBP4 correlated positively with adipose
RBP4 mRNA and intra-abdominal fat mass and inversely with insulin sensitivity, independently of age, gender, and body mass index.
RBP4 mRNA correlated inversely with
GLUT4 mRNA in Vis fat and positively with adipocyte size in both depots. RBP4 levels are therefore linked to Vis adiposity, and Vis fat may be a major source of RBP4 in insulin-resistant states.</description><identifier>ISSN: 1550-4131</identifier><identifier>EISSN: 1932-7420</identifier><identifier>DOI: 10.1016/j.cmet.2007.06.002</identifier><identifier>PMID: 17618858</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Adipose Tissue - cytology ; Adipose Tissue - metabolism ; Adult ; Biomarkers - metabolism ; Body Mass Index ; Diabetes Mellitus, Type 2 - blood ; Diabetes Mellitus, Type 2 - genetics ; Diabetes Mellitus, Type 2 - metabolism ; Female ; Humans ; HUMDISEASE ; Insulin Resistance ; Intra-Abdominal Fat - metabolism ; Intra-Abdominal Fat - pathology ; Male ; Middle Aged ; Obesity - blood ; Prealbumin - metabolism ; Retinol-Binding Proteins - genetics ; Retinol-Binding Proteins - metabolism ; Retinol-Binding Proteins, Plasma ; RNA, Messenger - genetics ; RNA, Messenger - metabolism ; Subcutaneous Fat - metabolism ; Subcutaneous Fat - pathology ; Thinness - blood</subject><ispartof>Cell metabolism, 2007-07, Vol.6 (1), p.79-87</ispartof><rights>2007 Elsevier Inc.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c464t-941ac944f7d9c2f6aa7caa3bea1945ab8f8ab7b3b486552dfb1398c34fbafbb33</citedby><cites>FETCH-LOGICAL-c464t-941ac944f7d9c2f6aa7caa3bea1945ab8f8ab7b3b486552dfb1398c34fbafbb33</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.cmet.2007.06.002$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17618858$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Klöting, Nora</creatorcontrib><creatorcontrib>Graham, Timothy E.</creatorcontrib><creatorcontrib>Berndt, Janin</creatorcontrib><creatorcontrib>Kralisch, Susan</creatorcontrib><creatorcontrib>Kovacs, Peter</creatorcontrib><creatorcontrib>Wason, Christopher J.</creatorcontrib><creatorcontrib>Fasshauer, Mathias</creatorcontrib><creatorcontrib>Schön, Michael R.</creatorcontrib><creatorcontrib>Stumvoll, Michael</creatorcontrib><creatorcontrib>Blüher, Matthias</creatorcontrib><creatorcontrib>Kahn, Barbara B.</creatorcontrib><title>Serum Retinol-Binding Protein Is More Highly Expressed in Visceral than in Subcutaneous Adipose Tissue and Is a Marker of Intra-abdominal Fat Mass</title><title>Cell metabolism</title><addtitle>Cell Metab</addtitle><description>Intra-abdominal fat is associated with insulin resistance and cardiovascular risk. Levels of serum retinol-binding protein (RBP4), secreted by fat and liver cells, are increased in obesity and type 2 diabetes (T2D). Here we report that, in 196 subjects, RBP4 is preferentially expressed in visceral (Vis) versus subcutaneous (SC) fat. Vis fat
RBP4 mRNA was increased ∼60-fold and 12-fold in Vis and SC obese subjects respectively versus lean subjects, and ∼2-fold with impaired glucose tolerance/T2D subjects versus normoglycemic subjects. In obese subjects, serum RBP4 was increased 2- to 3-fold, and serum transthyretin, which stabilizes RBP4 in the circulation, was increased 35%. Serum RBP4 correlated positively with adipose
RBP4 mRNA and intra-abdominal fat mass and inversely with insulin sensitivity, independently of age, gender, and body mass index.
RBP4 mRNA correlated inversely with
GLUT4 mRNA in Vis fat and positively with adipocyte size in both depots. RBP4 levels are therefore linked to Vis adiposity, and Vis fat may be a major source of RBP4 in insulin-resistant states.</description><subject>Adipose Tissue - cytology</subject><subject>Adipose Tissue - metabolism</subject><subject>Adult</subject><subject>Biomarkers - metabolism</subject><subject>Body Mass Index</subject><subject>Diabetes Mellitus, Type 2 - blood</subject><subject>Diabetes Mellitus, Type 2 - genetics</subject><subject>Diabetes Mellitus, Type 2 - metabolism</subject><subject>Female</subject><subject>Humans</subject><subject>HUMDISEASE</subject><subject>Insulin Resistance</subject><subject>Intra-Abdominal Fat - metabolism</subject><subject>Intra-Abdominal Fat - pathology</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Obesity - blood</subject><subject>Prealbumin - metabolism</subject><subject>Retinol-Binding Proteins - genetics</subject><subject>Retinol-Binding Proteins - metabolism</subject><subject>Retinol-Binding Proteins, Plasma</subject><subject>RNA, Messenger - genetics</subject><subject>RNA, Messenger - metabolism</subject><subject>Subcutaneous Fat - metabolism</subject><subject>Subcutaneous Fat - pathology</subject><subject>Thinness - blood</subject><issn>1550-4131</issn><issn>1932-7420</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kc1u1TAQhS0EoqXwAiyQV-yS2rHzJ7EpVUuv1ApEC1trbE9aXxL71nYQfQ2euInuldixmtHMmU86cwh5z1nJGW9Ot6WZMJcVY23JmpKx6gU55r2oilZW7OXS1zUrJBf8iLxJacuYaEQvXpMj3ja86-rumPy9xThP9Dtm58NYfHbeOn9Pv8WQ0Xm6SfQmRKRX7v5hfKIXf3YRU0JLl91PlwxGGGl-AL8Obmdt5gwew5zomXW7kJDeuZRmpODtCgN6A_EXRhoGuvE5QgHahsn5BXMJedmm9Ja8GmBM-O5QT8iPy4u786vi-uuXzfnZdWFkI3PRSw6ml3JobW-qoQFoDYDQCLyXNehu6EC3WmjZNXVd2UFz0XdGyEHDoLUQJ-TjnruL4XHGlNW0OhrHvQPVsqZvOVuF1V5oYkgp4qB20U0QnxRnak1CbdWahFqTUKxRSxLL0YcDfdYT2n8nh9cvgk97AS4efzuMKhmH3qB1EU1WNrj_8Z8BZGKccA</recordid><startdate>20070701</startdate><enddate>20070701</enddate><creator>Klöting, Nora</creator><creator>Graham, Timothy E.</creator><creator>Berndt, Janin</creator><creator>Kralisch, Susan</creator><creator>Kovacs, Peter</creator><creator>Wason, Christopher J.</creator><creator>Fasshauer, Mathias</creator><creator>Schön, Michael R.</creator><creator>Stumvoll, Michael</creator><creator>Blüher, Matthias</creator><creator>Kahn, Barbara B.</creator><general>Elsevier Inc</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20070701</creationdate><title>Serum Retinol-Binding Protein Is More Highly Expressed in Visceral than in Subcutaneous Adipose Tissue and Is a Marker of Intra-abdominal Fat Mass</title><author>Klöting, Nora ; Graham, Timothy E. ; Berndt, Janin ; Kralisch, Susan ; Kovacs, Peter ; Wason, Christopher J. ; Fasshauer, Mathias ; Schön, Michael R. ; Stumvoll, Michael ; Blüher, Matthias ; Kahn, Barbara B.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c464t-941ac944f7d9c2f6aa7caa3bea1945ab8f8ab7b3b486552dfb1398c34fbafbb33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Adipose Tissue - cytology</topic><topic>Adipose Tissue - metabolism</topic><topic>Adult</topic><topic>Biomarkers - metabolism</topic><topic>Body Mass Index</topic><topic>Diabetes Mellitus, Type 2 - blood</topic><topic>Diabetes Mellitus, Type 2 - genetics</topic><topic>Diabetes Mellitus, Type 2 - metabolism</topic><topic>Female</topic><topic>Humans</topic><topic>HUMDISEASE</topic><topic>Insulin Resistance</topic><topic>Intra-Abdominal Fat - metabolism</topic><topic>Intra-Abdominal Fat - pathology</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Obesity - blood</topic><topic>Prealbumin - metabolism</topic><topic>Retinol-Binding Proteins - genetics</topic><topic>Retinol-Binding Proteins - metabolism</topic><topic>Retinol-Binding Proteins, Plasma</topic><topic>RNA, Messenger - genetics</topic><topic>RNA, Messenger - metabolism</topic><topic>Subcutaneous Fat - metabolism</topic><topic>Subcutaneous Fat - pathology</topic><topic>Thinness - blood</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Klöting, Nora</creatorcontrib><creatorcontrib>Graham, Timothy E.</creatorcontrib><creatorcontrib>Berndt, Janin</creatorcontrib><creatorcontrib>Kralisch, Susan</creatorcontrib><creatorcontrib>Kovacs, Peter</creatorcontrib><creatorcontrib>Wason, Christopher J.</creatorcontrib><creatorcontrib>Fasshauer, Mathias</creatorcontrib><creatorcontrib>Schön, Michael R.</creatorcontrib><creatorcontrib>Stumvoll, Michael</creatorcontrib><creatorcontrib>Blüher, Matthias</creatorcontrib><creatorcontrib>Kahn, Barbara B.</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Cell metabolism</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Klöting, Nora</au><au>Graham, Timothy E.</au><au>Berndt, Janin</au><au>Kralisch, Susan</au><au>Kovacs, Peter</au><au>Wason, Christopher J.</au><au>Fasshauer, Mathias</au><au>Schön, Michael R.</au><au>Stumvoll, Michael</au><au>Blüher, Matthias</au><au>Kahn, Barbara B.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Serum Retinol-Binding Protein Is More Highly Expressed in Visceral than in Subcutaneous Adipose Tissue and Is a Marker of Intra-abdominal Fat Mass</atitle><jtitle>Cell metabolism</jtitle><addtitle>Cell Metab</addtitle><date>2007-07-01</date><risdate>2007</risdate><volume>6</volume><issue>1</issue><spage>79</spage><epage>87</epage><pages>79-87</pages><issn>1550-4131</issn><eissn>1932-7420</eissn><abstract>Intra-abdominal fat is associated with insulin resistance and cardiovascular risk. Levels of serum retinol-binding protein (RBP4), secreted by fat and liver cells, are increased in obesity and type 2 diabetes (T2D). Here we report that, in 196 subjects, RBP4 is preferentially expressed in visceral (Vis) versus subcutaneous (SC) fat. Vis fat
RBP4 mRNA was increased ∼60-fold and 12-fold in Vis and SC obese subjects respectively versus lean subjects, and ∼2-fold with impaired glucose tolerance/T2D subjects versus normoglycemic subjects. In obese subjects, serum RBP4 was increased 2- to 3-fold, and serum transthyretin, which stabilizes RBP4 in the circulation, was increased 35%. Serum RBP4 correlated positively with adipose
RBP4 mRNA and intra-abdominal fat mass and inversely with insulin sensitivity, independently of age, gender, and body mass index.
RBP4 mRNA correlated inversely with
GLUT4 mRNA in Vis fat and positively with adipocyte size in both depots. RBP4 levels are therefore linked to Vis adiposity, and Vis fat may be a major source of RBP4 in insulin-resistant states.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>17618858</pmid><doi>10.1016/j.cmet.2007.06.002</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Cell metabolism, 2007-07, Vol.6 (1), p.79-87 |
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| recordid | cdi_proquest_miscellaneous_70697103 |
| source | MEDLINE; Elsevier ScienceDirect Journals Complete; Cell Press Free Archives; EZB-FREE-00999 freely available EZB journals |
| subjects | Adipose Tissue - cytology Adipose Tissue - metabolism Adult Biomarkers - metabolism Body Mass Index Diabetes Mellitus, Type 2 - blood Diabetes Mellitus, Type 2 - genetics Diabetes Mellitus, Type 2 - metabolism Female Humans HUMDISEASE Insulin Resistance Intra-Abdominal Fat - metabolism Intra-Abdominal Fat - pathology Male Middle Aged Obesity - blood Prealbumin - metabolism Retinol-Binding Proteins - genetics Retinol-Binding Proteins - metabolism Retinol-Binding Proteins, Plasma RNA, Messenger - genetics RNA, Messenger - metabolism Subcutaneous Fat - metabolism Subcutaneous Fat - pathology Thinness - blood |
| title | Serum Retinol-Binding Protein Is More Highly Expressed in Visceral than in Subcutaneous Adipose Tissue and Is a Marker of Intra-abdominal Fat Mass |
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