Gangliosides promote platelet adhesion and facilitate neuroblastoma cell adhesion under dynamic conditions simulating blood flow

Background Aberrant gangliosides are produced and shed by some tumors into the extracellular milieu. Their concentration is related to disease progression in children with neuroblastoma and in experimental models. The mechanism for this tumor promoting effect is not known. Purpose Here, we investiga...

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Veröffentlicht in:	Pediatric Blood & Cancer 2006-03, Vol.46 (3), p.292-299
Hauptverfasser:	Jabbar, Adnan A., Kazarian, Tamara, Hakobyan, Narine, Valentino, Leonard A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Blood Flow Velocity Blood Platelets - metabolism Blood Platelets - pathology Cell Adhesion - drug effects Cell Line, Tumor Collagen - metabolism Gangliosides - metabolism Gangliosides - pharmacology General aspects Humans Medical sciences Neoplasm Metastasis neuroblastoma Neuroblastoma - metabolism Platelet Adhesiveness - drug effects platelets Stress, Mechanical tumor biology Tumors
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