Clopidogrel induced suppression of bovine platelet activation in vitro and a preliminary study of its effect on the development of Mannheimia haemolytica induced pneumonia

We report here on the influence of the platelet antagonist clopidogrel (Plavix) on bovine platelet function. We first evaluated the capacity of clopidogrel to inhibit adenosine diphosphate (ADP)-stimulated platelet function in the bovine species, using an ex vivo approach with blood from treated ani...

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Veröffentlicht in:	The veterinary journal (1997) 2006, Vol.171 (1), p.126-134
Hauptverfasser:	Coomber, Brenda L., Mitchell, Gordon B., Starr, Amanda E., Minhas, Kanwal, Tamblyn, Angela, Shewen, Patricia E., Gentry, Patricia A.
Format:	Artikel
Sprache:	eng
Schlagworte:	adenosine diphosphate Aggregation Animals antagonists Bovine pneumonia BRDC calves Cattle cattle diseases clopridogrel drug therapy fibrin in vitro studies in vivo studies lungs Male Mannheimia haemolytica pathophysiology platelet activation Platelet Aggregation - drug effects Platelet Aggregation - physiology Platelet Aggregation Inhibitors - pharmacology Platelet degranulation Platelet Function Tests - veterinary platelet-activating factor Pneumonia of Calves, Enzootic - drug therapy pneumonic pasteurellosis receptors Shipping fever Ticlopidine - analogs & derivatives Ticlopidine - pharmacology
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