Clopidogrel induced suppression of bovine platelet activation in vitro and a preliminary study of its effect on the development of Mannheimia haemolytica induced pneumonia
We report here on the influence of the platelet antagonist clopidogrel (Plavix) on bovine platelet function. We first evaluated the capacity of clopidogrel to inhibit adenosine diphosphate (ADP)-stimulated platelet function in the bovine species, using an ex vivo approach with blood from treated ani...
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| Veröffentlicht in: | The veterinary journal (1997) 2006, Vol.171 (1), p.126-134 |
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| container_title | The veterinary journal (1997) |
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| creator | Coomber, Brenda L. Mitchell, Gordon B. Starr, Amanda E. Minhas, Kanwal Tamblyn, Angela Shewen, Patricia E. Gentry, Patricia A. |
| description | We report here on the influence of the platelet antagonist clopidogrel (Plavix) on bovine platelet function. We first evaluated the capacity of clopidogrel to inhibit adenosine diphosphate (ADP)-stimulated platelet function in the bovine species, using an ex vivo approach with blood from treated animals. Platelets isolated from treated calves displayed rapid and consistent reduction in function (aggregation, thromboxane production) upon ADP, but not platelet activating factor (PAF), stimulation. We then examined the possibility that clopidogrel could influence
Mannheimia haemolytica pneumonia pathobiology using an experimental challenge model. We were unable to detect significant differences between clopidogrel treated and untreated animals when challenged with intra-tracheal inoculation of
M. haemolytica. There was a trend towards inhibition of platelet degranulation in the affected regions of lungs from clopidogrel treated calves, and pre-treated challenged animals had similar amounts of fibrin deposition and enhanced fibrous tissue formation in their lungs when compared with control counterparts. |
| doi_str_mv | 10.1016/j.tvjl.2004.09.008 |
| format | Article |
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Mannheimia haemolytica pneumonia pathobiology using an experimental challenge model. We were unable to detect significant differences between clopidogrel treated and untreated animals when challenged with intra-tracheal inoculation of
M. haemolytica. There was a trend towards inhibition of platelet degranulation in the affected regions of lungs from clopidogrel treated calves, and pre-treated challenged animals had similar amounts of fibrin deposition and enhanced fibrous tissue formation in their lungs when compared with control counterparts.</description><identifier>ISSN: 1090-0233</identifier><identifier>EISSN: 1532-2971</identifier><identifier>DOI: 10.1016/j.tvjl.2004.09.008</identifier><identifier>PMID: 16427590</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>adenosine diphosphate ; Aggregation ; Animals ; antagonists ; Bovine pneumonia ; BRDC ; calves ; Cattle ; cattle diseases ; clopridogrel ; drug therapy ; fibrin ; in vitro studies ; in vivo studies ; lungs ; Male ; Mannheimia haemolytica ; pathophysiology ; platelet activation ; Platelet Aggregation - drug effects ; Platelet Aggregation - physiology ; Platelet Aggregation Inhibitors - pharmacology ; Platelet degranulation ; Platelet Function Tests - veterinary ; platelet-activating factor ; Pneumonia of Calves, Enzootic - drug therapy ; pneumonic pasteurellosis ; receptors ; Shipping fever ; Ticlopidine - analogs & derivatives ; Ticlopidine - pharmacology</subject><ispartof>The veterinary journal (1997), 2006, Vol.171 (1), p.126-134</ispartof><rights>2004 Elsevier Ltd</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c378t-456468dd085b71f902c14f5ec99fbdf747c01e5d079d1a01c7cffd613eb3b5fd3</citedby><cites>FETCH-LOGICAL-c378t-456468dd085b71f902c14f5ec99fbdf747c01e5d079d1a01c7cffd613eb3b5fd3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S1090023304002035$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,4010,27900,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16427590$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Coomber, Brenda L.</creatorcontrib><creatorcontrib>Mitchell, Gordon B.</creatorcontrib><creatorcontrib>Starr, Amanda E.</creatorcontrib><creatorcontrib>Minhas, Kanwal</creatorcontrib><creatorcontrib>Tamblyn, Angela</creatorcontrib><creatorcontrib>Shewen, Patricia E.</creatorcontrib><creatorcontrib>Gentry, Patricia A.</creatorcontrib><title>Clopidogrel induced suppression of bovine platelet activation in vitro and a preliminary study of its effect on the development of Mannheimia haemolytica induced pneumonia</title><title>The veterinary journal (1997)</title><addtitle>Vet J</addtitle><description>We report here on the influence of the platelet antagonist clopidogrel (Plavix) on bovine platelet function. We first evaluated the capacity of clopidogrel to inhibit adenosine diphosphate (ADP)-stimulated platelet function in the bovine species, using an ex vivo approach with blood from treated animals. Platelets isolated from treated calves displayed rapid and consistent reduction in function (aggregation, thromboxane production) upon ADP, but not platelet activating factor (PAF), stimulation. We then examined the possibility that clopidogrel could influence
Mannheimia haemolytica pneumonia pathobiology using an experimental challenge model. We were unable to detect significant differences between clopidogrel treated and untreated animals when challenged with intra-tracheal inoculation of
M. haemolytica. There was a trend towards inhibition of platelet degranulation in the affected regions of lungs from clopidogrel treated calves, and pre-treated challenged animals had similar amounts of fibrin deposition and enhanced fibrous tissue formation in their lungs when compared with control counterparts.</description><subject>adenosine diphosphate</subject><subject>Aggregation</subject><subject>Animals</subject><subject>antagonists</subject><subject>Bovine pneumonia</subject><subject>BRDC</subject><subject>calves</subject><subject>Cattle</subject><subject>cattle diseases</subject><subject>clopridogrel</subject><subject>drug therapy</subject><subject>fibrin</subject><subject>in vitro studies</subject><subject>in vivo studies</subject><subject>lungs</subject><subject>Male</subject><subject>Mannheimia haemolytica</subject><subject>pathophysiology</subject><subject>platelet activation</subject><subject>Platelet Aggregation - drug effects</subject><subject>Platelet Aggregation - physiology</subject><subject>Platelet Aggregation Inhibitors - pharmacology</subject><subject>Platelet degranulation</subject><subject>Platelet Function Tests - veterinary</subject><subject>platelet-activating factor</subject><subject>Pneumonia of Calves, Enzootic - drug therapy</subject><subject>pneumonic pasteurellosis</subject><subject>receptors</subject><subject>Shipping fever</subject><subject>Ticlopidine - analogs & derivatives</subject><subject>Ticlopidine - pharmacology</subject><issn>1090-0233</issn><issn>1532-2971</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kc2OFCEUhStG4_zoC7hQVu6qvNRvk7gxHR1NxrjQWRMKLtN0KCiBqqSfyZeUsju6cwUJ3znce05RvKJQUaD9u2OV1qOtaoC2AlYB7J4U17Rr6rJmA32a78CghLpproqbGI8AwNq2fl5c0b6th47BdfFrb_1slH8MaIlxapGoSFzmOWCMxjviNRn9ahyS2YqEFhMRMplVpO3VOLKaFDwRThFBssqayTgRTiSmRZ02uUmRoNYoE8mKdECicMX87YQubcBX4dwBs06Qg8DJ21MyUvydZna4TN4Z8aJ4poWN-PJy3hYPnz7-2H8u77_dfdl_uC9lM-xS2XZ92--Ugl03DlQzqCVtdYeSMT0qPbSDBIqdgoEpKoDKQWqtetrg2IydVs1t8fbsOwf_c8GY-GSiRGuFQ79EPkDPuqGBDNZnUAYfY0DN52CmvDynwLeK-JFvFfGtIg6M54qy6PXFfRknVP8kl04y8OYMaOG5eAwm8ofvNdAGKHRd_cfi_ZnAnMJqMPAoDboclgk5Zq68-d8EvwGHb7E_</recordid><startdate>2006</startdate><enddate>2006</enddate><creator>Coomber, Brenda L.</creator><creator>Mitchell, Gordon B.</creator><creator>Starr, Amanda E.</creator><creator>Minhas, Kanwal</creator><creator>Tamblyn, Angela</creator><creator>Shewen, Patricia E.</creator><creator>Gentry, Patricia A.</creator><general>Elsevier Ltd</general><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>2006</creationdate><title>Clopidogrel induced suppression of bovine platelet activation in vitro and a preliminary study of its effect on the development of Mannheimia haemolytica induced pneumonia</title><author>Coomber, Brenda L. ; Mitchell, Gordon B. ; Starr, Amanda E. ; Minhas, Kanwal ; Tamblyn, Angela ; Shewen, Patricia E. ; Gentry, Patricia A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c378t-456468dd085b71f902c14f5ec99fbdf747c01e5d079d1a01c7cffd613eb3b5fd3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>adenosine diphosphate</topic><topic>Aggregation</topic><topic>Animals</topic><topic>antagonists</topic><topic>Bovine pneumonia</topic><topic>BRDC</topic><topic>calves</topic><topic>Cattle</topic><topic>cattle diseases</topic><topic>clopridogrel</topic><topic>drug therapy</topic><topic>fibrin</topic><topic>in vitro studies</topic><topic>in vivo studies</topic><topic>lungs</topic><topic>Male</topic><topic>Mannheimia haemolytica</topic><topic>pathophysiology</topic><topic>platelet activation</topic><topic>Platelet Aggregation - drug effects</topic><topic>Platelet Aggregation - physiology</topic><topic>Platelet Aggregation Inhibitors - pharmacology</topic><topic>Platelet degranulation</topic><topic>Platelet Function Tests - veterinary</topic><topic>platelet-activating factor</topic><topic>Pneumonia of Calves, Enzootic - drug therapy</topic><topic>pneumonic pasteurellosis</topic><topic>receptors</topic><topic>Shipping fever</topic><topic>Ticlopidine - analogs & derivatives</topic><topic>Ticlopidine - pharmacology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Coomber, Brenda L.</creatorcontrib><creatorcontrib>Mitchell, Gordon B.</creatorcontrib><creatorcontrib>Starr, Amanda E.</creatorcontrib><creatorcontrib>Minhas, Kanwal</creatorcontrib><creatorcontrib>Tamblyn, Angela</creatorcontrib><creatorcontrib>Shewen, Patricia E.</creatorcontrib><creatorcontrib>Gentry, Patricia A.</creatorcontrib><collection>AGRIS</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The veterinary journal (1997)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Coomber, Brenda L.</au><au>Mitchell, Gordon B.</au><au>Starr, Amanda E.</au><au>Minhas, Kanwal</au><au>Tamblyn, Angela</au><au>Shewen, Patricia E.</au><au>Gentry, Patricia A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Clopidogrel induced suppression of bovine platelet activation in vitro and a preliminary study of its effect on the development of Mannheimia haemolytica induced pneumonia</atitle><jtitle>The veterinary journal (1997)</jtitle><addtitle>Vet J</addtitle><date>2006</date><risdate>2006</risdate><volume>171</volume><issue>1</issue><spage>126</spage><epage>134</epage><pages>126-134</pages><issn>1090-0233</issn><eissn>1532-2971</eissn><abstract>We report here on the influence of the platelet antagonist clopidogrel (Plavix) on bovine platelet function. We first evaluated the capacity of clopidogrel to inhibit adenosine diphosphate (ADP)-stimulated platelet function in the bovine species, using an ex vivo approach with blood from treated animals. Platelets isolated from treated calves displayed rapid and consistent reduction in function (aggregation, thromboxane production) upon ADP, but not platelet activating factor (PAF), stimulation. We then examined the possibility that clopidogrel could influence
Mannheimia haemolytica pneumonia pathobiology using an experimental challenge model. We were unable to detect significant differences between clopidogrel treated and untreated animals when challenged with intra-tracheal inoculation of
M. haemolytica. There was a trend towards inhibition of platelet degranulation in the affected regions of lungs from clopidogrel treated calves, and pre-treated challenged animals had similar amounts of fibrin deposition and enhanced fibrous tissue formation in their lungs when compared with control counterparts.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>16427590</pmid><doi>10.1016/j.tvjl.2004.09.008</doi><tpages>9</tpages></addata></record> |
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| ispartof | The veterinary journal (1997), 2006, Vol.171 (1), p.126-134 |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | adenosine diphosphate Aggregation Animals antagonists Bovine pneumonia BRDC calves Cattle cattle diseases clopridogrel drug therapy fibrin in vitro studies in vivo studies lungs Male Mannheimia haemolytica pathophysiology platelet activation Platelet Aggregation - drug effects Platelet Aggregation - physiology Platelet Aggregation Inhibitors - pharmacology Platelet degranulation Platelet Function Tests - veterinary platelet-activating factor Pneumonia of Calves, Enzootic - drug therapy pneumonic pasteurellosis receptors Shipping fever Ticlopidine - analogs & derivatives Ticlopidine - pharmacology |
| title | Clopidogrel induced suppression of bovine platelet activation in vitro and a preliminary study of its effect on the development of Mannheimia haemolytica induced pneumonia |
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