Astragaloside IV from Astragalus membranaceus shows cardioprotection during myocardial ischemia in vivo and in vitro
Abstract Astragaloside IV is the major active constituent of ASTRAGALUS MEMBRANACEUS, which has been widely used for the treatment of cardiovascular diseases in China. However, the effects of astragaloside IV on myocardial ischemia and its mechanisms of action remain largely unknown. In this study,...
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| Veröffentlicht in: | Planta medica 2006-01, Vol.72 (1), p.4-8 |
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| creator | Zhang, W.D Chen, H Zhang, C Liu, R.H Li, H.L Chen, H.Z |
| description | Abstract
Astragaloside IV is the major active constituent of ASTRAGALUS MEMBRANACEUS, which has been widely used for the treatment of cardiovascular diseases in China. However, the effects of astragaloside IV on myocardial ischemia and its mechanisms of action remain largely unknown. In this study, we have examined the effects of astragaloside IV on myocardial infarction and coronary flow IN VIVO and IN VITRO. The possible roles of its antioxidative and nitric oxide-inducing properties were also explored. Astragaloside IV significantly reduced infarct size in dogs subjected to coronary ligation IN VIVO. Astragaloside IV also improved post-ischemic heart function and ameliorated reperfusion arrhythmias in rat hearts IN VITRO. The cardioprotection of astragaloside IV was accompanied by a significant increase in coronary flow both IN VIVO and IN VITRO. The nitric oxide synthase inhibitor, Nω
-nitro-L-arginine methyl ester partially abrogated astragaloside IV’s protective effect on heart function. Myocardial antioxidative enzyme superoxide dismutase activity increased with astragaloside IV administration. These data suggest the potential roles of antioxidative and nitric oxide-inducing properties of astragaloside IV in its protection from myocardial ischemia. |
| doi_str_mv | 10.1055/s-2005-873126 |
| format | Article |
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Astragaloside IV is the major active constituent of ASTRAGALUS MEMBRANACEUS, which has been widely used for the treatment of cardiovascular diseases in China. However, the effects of astragaloside IV on myocardial ischemia and its mechanisms of action remain largely unknown. In this study, we have examined the effects of astragaloside IV on myocardial infarction and coronary flow IN VIVO and IN VITRO. The possible roles of its antioxidative and nitric oxide-inducing properties were also explored. Astragaloside IV significantly reduced infarct size in dogs subjected to coronary ligation IN VIVO. Astragaloside IV also improved post-ischemic heart function and ameliorated reperfusion arrhythmias in rat hearts IN VITRO. The cardioprotection of astragaloside IV was accompanied by a significant increase in coronary flow both IN VIVO and IN VITRO. The nitric oxide synthase inhibitor, Nω
-nitro-L-arginine methyl ester partially abrogated astragaloside IV’s protective effect on heart function. Myocardial antioxidative enzyme superoxide dismutase activity increased with astragaloside IV administration. These data suggest the potential roles of antioxidative and nitric oxide-inducing properties of astragaloside IV in its protection from myocardial ischemia.</description><identifier>ISSN: 0032-0943</identifier><identifier>EISSN: 1439-0221</identifier><identifier>DOI: 10.1055/s-2005-873126</identifier><identifier>PMID: 16450288</identifier><language>eng</language><publisher>Germany</publisher><subject>Animals ; antioxidant activity ; astragaloside ; Astragalus membranaceus ; cardioprotective effect ; Dogs ; In Vitro Techniques ; Male ; medicinal plants ; Molecular Structure ; myocardial infarction ; myocardial ischemia ; Myocardial Ischemia - drug therapy ; Myocardial Ischemia - enzymology ; nitric oxide ; Nitric Oxide Synthase Type III - drug effects ; Original Paper ; Phytotherapy ; Plant Extracts - therapeutic use ; Plant Roots ; Rats ; Rats, Sprague-Dawley ; Salvia miltiorrhiza ; Saponins - pharmacology ; Saponins - therapeutic use ; Superoxide Dismutase - drug effects ; Triterpenes - pharmacology ; Triterpenes - therapeutic use</subject><ispartof>Planta medica, 2006-01, Vol.72 (1), p.4-8</ispartof><rights>Georg Thieme Verlag KG Stuttgart · New York</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.thieme-connect.de/products/ejournals/pdf/10.1055/s-2005-873126.pdf$$EPDF$$P50$$Gthieme$$H</linktopdf><linktohtml>$$Uhttps://www.thieme-connect.de/products/ejournals/html/10.1055/s-2005-873126$$EHTML$$P50$$Gthieme$$H</linktohtml><link.rule.ids>314,776,780,3005,27901,27902,54534,54535</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16450288$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zhang, W.D</creatorcontrib><creatorcontrib>Chen, H</creatorcontrib><creatorcontrib>Zhang, C</creatorcontrib><creatorcontrib>Liu, R.H</creatorcontrib><creatorcontrib>Li, H.L</creatorcontrib><creatorcontrib>Chen, H.Z</creatorcontrib><title>Astragaloside IV from Astragalus membranaceus shows cardioprotection during myocardial ischemia in vivo and in vitro</title><title>Planta medica</title><addtitle>Planta Med</addtitle><description>Abstract
Astragaloside IV is the major active constituent of ASTRAGALUS MEMBRANACEUS, which has been widely used for the treatment of cardiovascular diseases in China. However, the effects of astragaloside IV on myocardial ischemia and its mechanisms of action remain largely unknown. In this study, we have examined the effects of astragaloside IV on myocardial infarction and coronary flow IN VIVO and IN VITRO. The possible roles of its antioxidative and nitric oxide-inducing properties were also explored. Astragaloside IV significantly reduced infarct size in dogs subjected to coronary ligation IN VIVO. Astragaloside IV also improved post-ischemic heart function and ameliorated reperfusion arrhythmias in rat hearts IN VITRO. The cardioprotection of astragaloside IV was accompanied by a significant increase in coronary flow both IN VIVO and IN VITRO. The nitric oxide synthase inhibitor, Nω
-nitro-L-arginine methyl ester partially abrogated astragaloside IV’s protective effect on heart function. Myocardial antioxidative enzyme superoxide dismutase activity increased with astragaloside IV administration. These data suggest the potential roles of antioxidative and nitric oxide-inducing properties of astragaloside IV in its protection from myocardial ischemia.</description><subject>Animals</subject><subject>antioxidant activity</subject><subject>astragaloside</subject><subject>Astragalus membranaceus</subject><subject>cardioprotective effect</subject><subject>Dogs</subject><subject>In Vitro Techniques</subject><subject>Male</subject><subject>medicinal plants</subject><subject>Molecular Structure</subject><subject>myocardial infarction</subject><subject>myocardial ischemia</subject><subject>Myocardial Ischemia - drug therapy</subject><subject>Myocardial Ischemia - enzymology</subject><subject>nitric oxide</subject><subject>Nitric Oxide Synthase Type III - drug effects</subject><subject>Original Paper</subject><subject>Phytotherapy</subject><subject>Plant Extracts - therapeutic use</subject><subject>Plant Roots</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Salvia miltiorrhiza</subject><subject>Saponins - pharmacology</subject><subject>Saponins - therapeutic use</subject><subject>Superoxide Dismutase - drug effects</subject><subject>Triterpenes - pharmacology</subject><subject>Triterpenes - therapeutic use</subject><issn>0032-0943</issn><issn>1439-0221</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo1kTlPxDAQhS0EgmWhpAVXVATGdpzEJUIcKyFRcLSW18euURyDnYD492TJUs3Mm0-jp3kInRC4JMD5VS4oAC-amhFa7aAZKZkogFKyi2YAjBYgSnaADnN-ByClANhHB6QqOdCmmaH-OvdJrVQbszcWL96wSzHgf3XIONiwTKpT2o5DXsfvjLVKxsePFHurex87bIbkuxUOP_FvpVrss17b4BX2Hf7yXxGrzkx9n-IR2nOqzfZ4W-fo9e725eaheHy6X9xcPxaO1tAXDddlTbUwgtRWO7NslkpTVoFriHaktJpTQ5xrDOOkrLmonK04CEEMF446Nkfn093R6udgcy_D6Mu2repsHLKsoRIcymoET7fgsAzWyI_kg0o_8v9PI3AxAf3a22DlexxSN1qXBOQmBpnlJgY5xTDiZxPuVJRqlXyWr88UCIMRbjin7BfOWoMF</recordid><startdate>20060101</startdate><enddate>20060101</enddate><creator>Zhang, W.D</creator><creator>Chen, H</creator><creator>Zhang, C</creator><creator>Liu, R.H</creator><creator>Li, H.L</creator><creator>Chen, H.Z</creator><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>20060101</creationdate><title>Astragaloside IV from Astragalus membranaceus shows cardioprotection during myocardial ischemia in vivo and in vitro</title><author>Zhang, W.D ; Chen, H ; Zhang, C ; Liu, R.H ; Li, H.L ; Chen, H.Z</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-f270t-85c472c9d917ecfdb8bac2360f81cf14ec52d1ff8d35147596fe650991d59f2f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Animals</topic><topic>antioxidant activity</topic><topic>astragaloside</topic><topic>Astragalus membranaceus</topic><topic>cardioprotective effect</topic><topic>Dogs</topic><topic>In Vitro Techniques</topic><topic>Male</topic><topic>medicinal plants</topic><topic>Molecular Structure</topic><topic>myocardial infarction</topic><topic>myocardial ischemia</topic><topic>Myocardial Ischemia - drug therapy</topic><topic>Myocardial Ischemia - enzymology</topic><topic>nitric oxide</topic><topic>Nitric Oxide Synthase Type III - drug effects</topic><topic>Original Paper</topic><topic>Phytotherapy</topic><topic>Plant Extracts - therapeutic use</topic><topic>Plant Roots</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Salvia miltiorrhiza</topic><topic>Saponins - pharmacology</topic><topic>Saponins - therapeutic use</topic><topic>Superoxide Dismutase - drug effects</topic><topic>Triterpenes - pharmacology</topic><topic>Triterpenes - therapeutic use</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zhang, W.D</creatorcontrib><creatorcontrib>Chen, H</creatorcontrib><creatorcontrib>Zhang, C</creatorcontrib><creatorcontrib>Liu, R.H</creatorcontrib><creatorcontrib>Li, H.L</creatorcontrib><creatorcontrib>Chen, H.Z</creatorcontrib><collection>AGRIS</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Planta medica</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhang, W.D</au><au>Chen, H</au><au>Zhang, C</au><au>Liu, R.H</au><au>Li, H.L</au><au>Chen, H.Z</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Astragaloside IV from Astragalus membranaceus shows cardioprotection during myocardial ischemia in vivo and in vitro</atitle><jtitle>Planta medica</jtitle><addtitle>Planta Med</addtitle><date>2006-01-01</date><risdate>2006</risdate><volume>72</volume><issue>1</issue><spage>4</spage><epage>8</epage><pages>4-8</pages><issn>0032-0943</issn><eissn>1439-0221</eissn><abstract>Abstract
Astragaloside IV is the major active constituent of ASTRAGALUS MEMBRANACEUS, which has been widely used for the treatment of cardiovascular diseases in China. However, the effects of astragaloside IV on myocardial ischemia and its mechanisms of action remain largely unknown. In this study, we have examined the effects of astragaloside IV on myocardial infarction and coronary flow IN VIVO and IN VITRO. The possible roles of its antioxidative and nitric oxide-inducing properties were also explored. Astragaloside IV significantly reduced infarct size in dogs subjected to coronary ligation IN VIVO. Astragaloside IV also improved post-ischemic heart function and ameliorated reperfusion arrhythmias in rat hearts IN VITRO. The cardioprotection of astragaloside IV was accompanied by a significant increase in coronary flow both IN VIVO and IN VITRO. The nitric oxide synthase inhibitor, Nω
-nitro-L-arginine methyl ester partially abrogated astragaloside IV’s protective effect on heart function. Myocardial antioxidative enzyme superoxide dismutase activity increased with astragaloside IV administration. These data suggest the potential roles of antioxidative and nitric oxide-inducing properties of astragaloside IV in its protection from myocardial ischemia.</abstract><cop>Germany</cop><pmid>16450288</pmid><doi>10.1055/s-2005-873126</doi><tpages>5</tpages></addata></record> |
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| subjects | Animals antioxidant activity astragaloside Astragalus membranaceus cardioprotective effect Dogs In Vitro Techniques Male medicinal plants Molecular Structure myocardial infarction myocardial ischemia Myocardial Ischemia - drug therapy Myocardial Ischemia - enzymology nitric oxide Nitric Oxide Synthase Type III - drug effects Original Paper Phytotherapy Plant Extracts - therapeutic use Plant Roots Rats Rats, Sprague-Dawley Salvia miltiorrhiza Saponins - pharmacology Saponins - therapeutic use Superoxide Dismutase - drug effects Triterpenes - pharmacology Triterpenes - therapeutic use |
| title | Astragaloside IV from Astragalus membranaceus shows cardioprotection during myocardial ischemia in vivo and in vitro |
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