Activation of endogenous retrovirus reverse transcriptase in multiple sclerosis patient lymphocytes by inactivated HSV-1, HHV-6 and VZV
Abstract Human endogenous retroviruses (HERVs) and herpesviruses have been associated with the development of multiple sclerosis (MS). These virus groups interact with each other and have been shown to induce synergistic immune responses. Here, we focus on the possible role of herpesviruses as contr...
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| Veröffentlicht in: | Journal of neuroimmunology 2007-07, Vol.187 (1), p.147-155 |
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| creator | Brudek, Tomasz Lühdorf, Pernille Christensen, Tove Hansen, Hans Jacob Møller-Larsen, Anné |
| description | Abstract Human endogenous retroviruses (HERVs) and herpesviruses have been associated with the development of multiple sclerosis (MS). These virus groups interact with each other and have been shown to induce synergistic immune responses. Here, we focus on the possible role of herpesviruses as contributing factors in HERV activation. We demonstrate the ability of HSV-1, HHV-6, and VZV antigens to induce higher RT activity in peripheral lymphocytes from MS patients vs. controls during the first 6 days post-antigen stimulation. On subsequent days, only VZV can sustain the increase in the RT expression in cells from MS patients. The RT induction does not depend on herpes replication. |
| doi_str_mv | 10.1016/j.jneuroim.2007.04.003 |
| format | Article |
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These virus groups interact with each other and have been shown to induce synergistic immune responses. Here, we focus on the possible role of herpesviruses as contributing factors in HERV activation. We demonstrate the ability of HSV-1, HHV-6, and VZV antigens to induce higher RT activity in peripheral lymphocytes from MS patients vs. controls during the first 6 days post-antigen stimulation. On subsequent days, only VZV can sustain the increase in the RT expression in cells from MS patients. The RT induction does not depend on herpes replication.</description><identifier>ISSN: 0165-5728</identifier><identifier>EISSN: 1872-8421</identifier><identifier>DOI: 10.1016/j.jneuroim.2007.04.003</identifier><identifier>PMID: 17493688</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Adult ; Allergy and Immunology ; Antigens, Viral - immunology ; Cell Proliferation ; Dose-Response Relationship, Immunologic ; Endogenous Retroviruses - metabolism ; Enzyme Activation - immunology ; Female ; Gene Expression Regulation, Viral - physiology ; Herpes simplex virus 1 ; Herpesvirus 1, Human - immunology ; Herpesvirus 3, Human - immunology ; Herpesvirus 6, Human - immunology ; Herpesviruses ; Human endogenous retrovirus ; Human herpesvirus 6 ; Humans ; Lymphocyte Activation ; Lymphocytes - immunology ; Male ; Middle Aged ; Multiple sclerosis ; Multiple Sclerosis - pathology ; Neurology ; Reverse transcriptase ; Reverse Transcriptase Polymerase Chain Reaction ; RNA-Directed DNA Polymerase - metabolism ; Time Factors ; Varicella-zoster virus ; Virus Activation</subject><ispartof>Journal of neuroimmunology, 2007-07, Vol.187 (1), p.147-155</ispartof><rights>Elsevier B.V.</rights><rights>2007 Elsevier B.V.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c452t-6ed48605540d6799eda58da9d48f9c166cbc50929c00e8ac3ffc2949085598e83</citedby><cites>FETCH-LOGICAL-c452t-6ed48605540d6799eda58da9d48f9c166cbc50929c00e8ac3ffc2949085598e83</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.jneuroim.2007.04.003$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,777,781,3537,27905,27906,45976</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17493688$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Brudek, Tomasz</creatorcontrib><creatorcontrib>Lühdorf, Pernille</creatorcontrib><creatorcontrib>Christensen, Tove</creatorcontrib><creatorcontrib>Hansen, Hans Jacob</creatorcontrib><creatorcontrib>Møller-Larsen, Anné</creatorcontrib><title>Activation of endogenous retrovirus reverse transcriptase in multiple sclerosis patient lymphocytes by inactivated HSV-1, HHV-6 and VZV</title><title>Journal of neuroimmunology</title><addtitle>J Neuroimmunol</addtitle><description>Abstract Human endogenous retroviruses (HERVs) and herpesviruses have been associated with the development of multiple sclerosis (MS). These virus groups interact with each other and have been shown to induce synergistic immune responses. Here, we focus on the possible role of herpesviruses as contributing factors in HERV activation. We demonstrate the ability of HSV-1, HHV-6, and VZV antigens to induce higher RT activity in peripheral lymphocytes from MS patients vs. controls during the first 6 days post-antigen stimulation. On subsequent days, only VZV can sustain the increase in the RT expression in cells from MS patients. The RT induction does not depend on herpes replication.</description><subject>Adult</subject><subject>Allergy and Immunology</subject><subject>Antigens, Viral - immunology</subject><subject>Cell Proliferation</subject><subject>Dose-Response Relationship, Immunologic</subject><subject>Endogenous Retroviruses - metabolism</subject><subject>Enzyme Activation - immunology</subject><subject>Female</subject><subject>Gene Expression Regulation, Viral - physiology</subject><subject>Herpes simplex virus 1</subject><subject>Herpesvirus 1, Human - immunology</subject><subject>Herpesvirus 3, Human - immunology</subject><subject>Herpesvirus 6, Human - immunology</subject><subject>Herpesviruses</subject><subject>Human endogenous retrovirus</subject><subject>Human herpesvirus 6</subject><subject>Humans</subject><subject>Lymphocyte Activation</subject><subject>Lymphocytes - immunology</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Multiple sclerosis</subject><subject>Multiple Sclerosis - pathology</subject><subject>Neurology</subject><subject>Reverse transcriptase</subject><subject>Reverse Transcriptase Polymerase Chain Reaction</subject><subject>RNA-Directed DNA Polymerase - metabolism</subject><subject>Time Factors</subject><subject>Varicella-zoster virus</subject><subject>Virus Activation</subject><issn>0165-5728</issn><issn>1872-8421</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFks9u1DAQxiMEotvCK1Q-cSLL2Ekc-4KoKmCRKnEo7IGL5XUm4CWxg-2slCfgtfF2FyFx6cl_9Jv5NN83RXFNYU2B8jf79d7hHLwd1wygXUO9BqieFCsqWlaKmtGnxSqDTdm0TFwUlzHuAWhT1fJ5cUHbWlZciFXx-8Yke9DJekd8T9B1_js6P0cSMAV_sOHhesAQkaSgXTTBTknnl3VknIdkpwFJNAMGH20kU-6FLpFhGacf3iwJI9ktGdYnIezI5n5b0tdks9mWnGjXke237YviWa-HiC_P51Xx9cP7L7eb8u7zx0-3N3elqRuWSo5dLTg0TQ0db6XETjei0zL_9tJQzs3ONCCZNAAotKn63jBZSxBNIwWK6qp4deo7Bf9rxpjUaKPBYdAO89SqBS7rislHQSpbygRnGeQn0GQDYsBeTcGOOiyKgjpmpfbqb1bqmJWCWuWscuH1WWHejdj9KzuHk4F3JwCzIQeLQUWTvTXY2YAmqc7bxzXe_tfCDNZZo4efuGDc-zm4bLeiKjIF6v64MceFgTYvC2uh-gP_VL_k</recordid><startdate>20070701</startdate><enddate>20070701</enddate><creator>Brudek, Tomasz</creator><creator>Lühdorf, Pernille</creator><creator>Christensen, Tove</creator><creator>Hansen, Hans Jacob</creator><creator>Møller-Larsen, Anné</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7TK</scope><scope>7TM</scope><scope>7U9</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>20070701</creationdate><title>Activation of endogenous retrovirus reverse transcriptase in multiple sclerosis patient lymphocytes by inactivated HSV-1, HHV-6 and VZV</title><author>Brudek, Tomasz ; Lühdorf, Pernille ; Christensen, Tove ; Hansen, Hans Jacob ; Møller-Larsen, Anné</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c452t-6ed48605540d6799eda58da9d48f9c166cbc50929c00e8ac3ffc2949085598e83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Adult</topic><topic>Allergy and Immunology</topic><topic>Antigens, Viral - immunology</topic><topic>Cell Proliferation</topic><topic>Dose-Response Relationship, Immunologic</topic><topic>Endogenous Retroviruses - metabolism</topic><topic>Enzyme Activation - immunology</topic><topic>Female</topic><topic>Gene Expression Regulation, Viral - physiology</topic><topic>Herpes simplex virus 1</topic><topic>Herpesvirus 1, Human - immunology</topic><topic>Herpesvirus 3, Human - immunology</topic><topic>Herpesvirus 6, Human - immunology</topic><topic>Herpesviruses</topic><topic>Human endogenous retrovirus</topic><topic>Human herpesvirus 6</topic><topic>Humans</topic><topic>Lymphocyte Activation</topic><topic>Lymphocytes - immunology</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Multiple sclerosis</topic><topic>Multiple Sclerosis - pathology</topic><topic>Neurology</topic><topic>Reverse transcriptase</topic><topic>Reverse Transcriptase Polymerase Chain Reaction</topic><topic>RNA-Directed DNA Polymerase - metabolism</topic><topic>Time Factors</topic><topic>Varicella-zoster virus</topic><topic>Virus Activation</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Brudek, Tomasz</creatorcontrib><creatorcontrib>Lühdorf, Pernille</creatorcontrib><creatorcontrib>Christensen, Tove</creatorcontrib><creatorcontrib>Hansen, Hans Jacob</creatorcontrib><creatorcontrib>Møller-Larsen, Anné</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of neuroimmunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Brudek, Tomasz</au><au>Lühdorf, Pernille</au><au>Christensen, Tove</au><au>Hansen, Hans Jacob</au><au>Møller-Larsen, Anné</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Activation of endogenous retrovirus reverse transcriptase in multiple sclerosis patient lymphocytes by inactivated HSV-1, HHV-6 and VZV</atitle><jtitle>Journal of neuroimmunology</jtitle><addtitle>J Neuroimmunol</addtitle><date>2007-07-01</date><risdate>2007</risdate><volume>187</volume><issue>1</issue><spage>147</spage><epage>155</epage><pages>147-155</pages><issn>0165-5728</issn><eissn>1872-8421</eissn><abstract>Abstract Human endogenous retroviruses (HERVs) and herpesviruses have been associated with the development of multiple sclerosis (MS). These virus groups interact with each other and have been shown to induce synergistic immune responses. Here, we focus on the possible role of herpesviruses as contributing factors in HERV activation. We demonstrate the ability of HSV-1, HHV-6, and VZV antigens to induce higher RT activity in peripheral lymphocytes from MS patients vs. controls during the first 6 days post-antigen stimulation. On subsequent days, only VZV can sustain the increase in the RT expression in cells from MS patients. The RT induction does not depend on herpes replication.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>17493688</pmid><doi>10.1016/j.jneuroim.2007.04.003</doi><tpages>9</tpages></addata></record> |
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| subjects | Adult Allergy and Immunology Antigens, Viral - immunology Cell Proliferation Dose-Response Relationship, Immunologic Endogenous Retroviruses - metabolism Enzyme Activation - immunology Female Gene Expression Regulation, Viral - physiology Herpes simplex virus 1 Herpesvirus 1, Human - immunology Herpesvirus 3, Human - immunology Herpesvirus 6, Human - immunology Herpesviruses Human endogenous retrovirus Human herpesvirus 6 Humans Lymphocyte Activation Lymphocytes - immunology Male Middle Aged Multiple sclerosis Multiple Sclerosis - pathology Neurology Reverse transcriptase Reverse Transcriptase Polymerase Chain Reaction RNA-Directed DNA Polymerase - metabolism Time Factors Varicella-zoster virus Virus Activation |
| title | Activation of endogenous retrovirus reverse transcriptase in multiple sclerosis patient lymphocytes by inactivated HSV-1, HHV-6 and VZV |
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