Vitamin antioxidants, lipid peroxidation and the systemic inflammatory response in patients with prostate cancer
The relationship between lipid soluble antioxidant vitamins, lipid peroxidation, disease stage and the systemic inflammatory response were examined in healthy subjects (n = 14), patients with benign prostate hyperplasia BPH (n = 20), localized (n = 40) and metastatic (n = 38) prostate cancer. Prosta...
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| Veröffentlicht in: | International journal of cancer 2006-02, Vol.118 (4), p.1051-1053 |
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| container_title | International journal of cancer |
| container_volume | 118 |
| creator | Almushatat, Ahmed S.K. Talwar, Dinesh McArdle, Peter A. Williamson, Cathy Sattar, Naveed O'Reilly, Denis St. J Underwood, Mark A. McMillan, Donald C. |
| description | The relationship between lipid soluble antioxidant vitamins, lipid peroxidation, disease stage and the systemic inflammatory response were examined in healthy subjects (n = 14), patients with benign prostate hyperplasia BPH (n = 20), localized (n = 40) and metastatic (n = 38) prostate cancer. Prostate cancer patients had higher concentrations of malondialdehyde (p < 0.05) and lower circulating concentrations of lutein (p < 0.05), lycopene (p < 0.001) and β‐carotene (p < 0.05). Patients with metastatic prostate cancer, when compared with patients having localized disease, had a higher Gleason score (p < 0.01) and had more hormonal treatment, but lower concentrations of PSA (p < 0.05), α‐tocopherol (p ≤ 0.05), retinol (p < 0.01), lutein (p < 0.05) and lycopene (p < 0.01). In the prostate cancer patients, PSA was correlated with the concentrations of the lipid peroxidation product, malondialdehyde (rs = 0.353, p = 0.002). C‐reactive protein was not correlated with the vitamin antioxidants nor malondialdehyde. In contrast, there was a negative correlation between malondialdehyde concentrations and both lutein (rs = −0.263, p = 0.020) and lycopene (rs = −0.269, p = 0.017). These results indicate that lower concentrations of carotenoids, in particular, lycopene reflect disease progression rather than the systemic inflammatory response in patients with prostate cancer. © 2005 Wiley‐Liss, Inc. |
| doi_str_mv | 10.1002/ijc.21451 |
| format | Article |
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Prostate cancer patients had higher concentrations of malondialdehyde (p < 0.05) and lower circulating concentrations of lutein (p < 0.05), lycopene (p < 0.001) and β‐carotene (p < 0.05). Patients with metastatic prostate cancer, when compared with patients having localized disease, had a higher Gleason score (p < 0.01) and had more hormonal treatment, but lower concentrations of PSA (p < 0.05), α‐tocopherol (p ≤ 0.05), retinol (p < 0.01), lutein (p < 0.05) and lycopene (p < 0.01). In the prostate cancer patients, PSA was correlated with the concentrations of the lipid peroxidation product, malondialdehyde (rs = 0.353, p = 0.002). C‐reactive protein was not correlated with the vitamin antioxidants nor malondialdehyde. In contrast, there was a negative correlation between malondialdehyde concentrations and both lutein (rs = −0.263, p = 0.020) and lycopene (rs = −0.269, p = 0.017). These results indicate that lower concentrations of carotenoids, in particular, lycopene reflect disease progression rather than the systemic inflammatory response in patients with prostate cancer. © 2005 Wiley‐Liss, Inc.]]></description><identifier>ISSN: 0020-7136</identifier><identifier>EISSN: 1097-0215</identifier><identifier>DOI: 10.1002/ijc.21451</identifier><identifier>PMID: 16106418</identifier><identifier>CODEN: IJCNAW</identifier><language>eng</language><publisher>Hoboken: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>Aged ; Aged, 80 and over ; Antineoplastic Agents, Hormonal - therapeutic use ; Antioxidants - analysis ; Biological and medical sciences ; carotenoids ; Carotenoids - blood ; Case-Control Studies ; C‐reactive protein ; Disease Progression ; Humans ; Inflammation ; Lipid Peroxidation ; Male ; Malondialdehyde - blood ; malonyldialdehyde ; Medical sciences ; Middle Aged ; Neoplasm Metastasis ; Neoplasm Staging ; Nephrology. Urinary tract diseases ; Oxidative Stress ; prostate cancer ; Prostatic Hyperplasia - immunology ; Prostatic Hyperplasia - physiopathology ; Prostatic Neoplasms - immunology ; Prostatic Neoplasms - physiopathology ; retinol ; systemic inflammatory response ; Tumors ; Tumors of the urinary system ; Urinary tract. Prostate gland ; α‐tocopherol</subject><ispartof>International journal of cancer, 2006-02, Vol.118 (4), p.1051-1053</ispartof><rights>Copyright © 2005 Wiley‐Liss, Inc.</rights><rights>2006 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3881-784c98a9e63b37d0e7ebf1193421c40699d6e30d127e4eabdfb3f5281bdc26c53</citedby><cites>FETCH-LOGICAL-c3881-784c98a9e63b37d0e7ebf1193421c40699d6e30d127e4eabdfb3f5281bdc26c53</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fijc.21451$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fijc.21451$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>315,781,785,1418,27929,27930,45579,45580</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=17538231$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16106418$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Almushatat, Ahmed S.K.</creatorcontrib><creatorcontrib>Talwar, Dinesh</creatorcontrib><creatorcontrib>McArdle, Peter A.</creatorcontrib><creatorcontrib>Williamson, Cathy</creatorcontrib><creatorcontrib>Sattar, Naveed</creatorcontrib><creatorcontrib>O'Reilly, Denis St. J</creatorcontrib><creatorcontrib>Underwood, Mark A.</creatorcontrib><creatorcontrib>McMillan, Donald C.</creatorcontrib><title>Vitamin antioxidants, lipid peroxidation and the systemic inflammatory response in patients with prostate cancer</title><title>International journal of cancer</title><addtitle>Int J Cancer</addtitle><description><![CDATA[The relationship between lipid soluble antioxidant vitamins, lipid peroxidation, disease stage and the systemic inflammatory response were examined in healthy subjects (n = 14), patients with benign prostate hyperplasia BPH (n = 20), localized (n = 40) and metastatic (n = 38) prostate cancer. Prostate cancer patients had higher concentrations of malondialdehyde (p < 0.05) and lower circulating concentrations of lutein (p < 0.05), lycopene (p < 0.001) and β‐carotene (p < 0.05). Patients with metastatic prostate cancer, when compared with patients having localized disease, had a higher Gleason score (p < 0.01) and had more hormonal treatment, but lower concentrations of PSA (p < 0.05), α‐tocopherol (p ≤ 0.05), retinol (p < 0.01), lutein (p < 0.05) and lycopene (p < 0.01). In the prostate cancer patients, PSA was correlated with the concentrations of the lipid peroxidation product, malondialdehyde (rs = 0.353, p = 0.002). C‐reactive protein was not correlated with the vitamin antioxidants nor malondialdehyde. In contrast, there was a negative correlation between malondialdehyde concentrations and both lutein (rs = −0.263, p = 0.020) and lycopene (rs = −0.269, p = 0.017). These results indicate that lower concentrations of carotenoids, in particular, lycopene reflect disease progression rather than the systemic inflammatory response in patients with prostate cancer. © 2005 Wiley‐Liss, Inc.]]></description><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Antineoplastic Agents, Hormonal - therapeutic use</subject><subject>Antioxidants - analysis</subject><subject>Biological and medical sciences</subject><subject>carotenoids</subject><subject>Carotenoids - blood</subject><subject>Case-Control Studies</subject><subject>C‐reactive protein</subject><subject>Disease Progression</subject><subject>Humans</subject><subject>Inflammation</subject><subject>Lipid Peroxidation</subject><subject>Male</subject><subject>Malondialdehyde - blood</subject><subject>malonyldialdehyde</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Neoplasm Metastasis</subject><subject>Neoplasm Staging</subject><subject>Nephrology. Urinary tract diseases</subject><subject>Oxidative Stress</subject><subject>prostate cancer</subject><subject>Prostatic Hyperplasia - immunology</subject><subject>Prostatic Hyperplasia - physiopathology</subject><subject>Prostatic Neoplasms - immunology</subject><subject>Prostatic Neoplasms - physiopathology</subject><subject>retinol</subject><subject>systemic inflammatory response</subject><subject>Tumors</subject><subject>Tumors of the urinary system</subject><subject>Urinary tract. Prostate gland</subject><subject>α‐tocopherol</subject><issn>0020-7136</issn><issn>1097-0215</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kEtLQzEQhYMoWqsL_4BkoyB420xyn0spPioFN-r2kpvMxch9maTU_nvTB3TlamDmm3NmDiFXwCbAGJ-abzXhECdwREbAiixiHJJjMgozFmUg0jNy7tw3YwAJi0_JGaTA0hjyERk-jZet6ajsvOl_jQ7V3dPGDEbTAe22FSYbQFP_hdStncfWKGq6upFtK31v19SiG_rOYejSISxgkKEr47_oYHvnpUeqZKfQXpCTWjYOL_d1TD6eHt9nL9Hi7Xk-e1hESuQ5RFkeqyKXBaaiEplmmGFVAxQi5qBilhaFTlEwDTzDGGWl60rUCc-h0oqnKhFjcrvTDf4_S3S-bI1T2DSyw37pyixoxJzzAN7tQBUOdRbrcrCmlXZdAis38ZYh3nIbb2Cv96LLqkV9IPd5BuBmD0inZFPb8LNxBy5LRM7FRmi641amwfX_juX8dbaz_gMEqpNA</recordid><startdate>20060215</startdate><enddate>20060215</enddate><creator>Almushatat, Ahmed S.K.</creator><creator>Talwar, Dinesh</creator><creator>McArdle, Peter A.</creator><creator>Williamson, Cathy</creator><creator>Sattar, Naveed</creator><creator>O'Reilly, Denis St. J</creator><creator>Underwood, Mark A.</creator><creator>McMillan, Donald C.</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><general>Wiley-Liss</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20060215</creationdate><title>Vitamin antioxidants, lipid peroxidation and the systemic inflammatory response in patients with prostate cancer</title><author>Almushatat, Ahmed S.K. ; Talwar, Dinesh ; McArdle, Peter A. ; Williamson, Cathy ; Sattar, Naveed ; O'Reilly, Denis St. J ; Underwood, Mark A. ; McMillan, Donald C.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3881-784c98a9e63b37d0e7ebf1193421c40699d6e30d127e4eabdfb3f5281bdc26c53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Antineoplastic Agents, Hormonal - therapeutic use</topic><topic>Antioxidants - analysis</topic><topic>Biological and medical sciences</topic><topic>carotenoids</topic><topic>Carotenoids - blood</topic><topic>Case-Control Studies</topic><topic>C‐reactive protein</topic><topic>Disease Progression</topic><topic>Humans</topic><topic>Inflammation</topic><topic>Lipid Peroxidation</topic><topic>Male</topic><topic>Malondialdehyde - blood</topic><topic>malonyldialdehyde</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Neoplasm Metastasis</topic><topic>Neoplasm Staging</topic><topic>Nephrology. Urinary tract diseases</topic><topic>Oxidative Stress</topic><topic>prostate cancer</topic><topic>Prostatic Hyperplasia - immunology</topic><topic>Prostatic Hyperplasia - physiopathology</topic><topic>Prostatic Neoplasms - immunology</topic><topic>Prostatic Neoplasms - physiopathology</topic><topic>retinol</topic><topic>systemic inflammatory response</topic><topic>Tumors</topic><topic>Tumors of the urinary system</topic><topic>Urinary tract. Prostate gland</topic><topic>α‐tocopherol</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Almushatat, Ahmed S.K.</creatorcontrib><creatorcontrib>Talwar, Dinesh</creatorcontrib><creatorcontrib>McArdle, Peter A.</creatorcontrib><creatorcontrib>Williamson, Cathy</creatorcontrib><creatorcontrib>Sattar, Naveed</creatorcontrib><creatorcontrib>O'Reilly, Denis St. J</creatorcontrib><creatorcontrib>Underwood, Mark A.</creatorcontrib><creatorcontrib>McMillan, Donald C.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>International journal of cancer</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Almushatat, Ahmed S.K.</au><au>Talwar, Dinesh</au><au>McArdle, Peter A.</au><au>Williamson, Cathy</au><au>Sattar, Naveed</au><au>O'Reilly, Denis St. J</au><au>Underwood, Mark A.</au><au>McMillan, Donald C.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Vitamin antioxidants, lipid peroxidation and the systemic inflammatory response in patients with prostate cancer</atitle><jtitle>International journal of cancer</jtitle><addtitle>Int J Cancer</addtitle><date>2006-02-15</date><risdate>2006</risdate><volume>118</volume><issue>4</issue><spage>1051</spage><epage>1053</epage><pages>1051-1053</pages><issn>0020-7136</issn><eissn>1097-0215</eissn><coden>IJCNAW</coden><abstract><![CDATA[The relationship between lipid soluble antioxidant vitamins, lipid peroxidation, disease stage and the systemic inflammatory response were examined in healthy subjects (n = 14), patients with benign prostate hyperplasia BPH (n = 20), localized (n = 40) and metastatic (n = 38) prostate cancer. Prostate cancer patients had higher concentrations of malondialdehyde (p < 0.05) and lower circulating concentrations of lutein (p < 0.05), lycopene (p < 0.001) and β‐carotene (p < 0.05). Patients with metastatic prostate cancer, when compared with patients having localized disease, had a higher Gleason score (p < 0.01) and had more hormonal treatment, but lower concentrations of PSA (p < 0.05), α‐tocopherol (p ≤ 0.05), retinol (p < 0.01), lutein (p < 0.05) and lycopene (p < 0.01). In the prostate cancer patients, PSA was correlated with the concentrations of the lipid peroxidation product, malondialdehyde (rs = 0.353, p = 0.002). C‐reactive protein was not correlated with the vitamin antioxidants nor malondialdehyde. In contrast, there was a negative correlation between malondialdehyde concentrations and both lutein (rs = −0.263, p = 0.020) and lycopene (rs = −0.269, p = 0.017). These results indicate that lower concentrations of carotenoids, in particular, lycopene reflect disease progression rather than the systemic inflammatory response in patients with prostate cancer. © 2005 Wiley‐Liss, Inc.]]></abstract><cop>Hoboken</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>16106418</pmid><doi>10.1002/ijc.21451</doi><tpages>3</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Aged Aged, 80 and over Antineoplastic Agents, Hormonal - therapeutic use Antioxidants - analysis Biological and medical sciences carotenoids Carotenoids - blood Case-Control Studies C‐reactive protein Disease Progression Humans Inflammation Lipid Peroxidation Male Malondialdehyde - blood malonyldialdehyde Medical sciences Middle Aged Neoplasm Metastasis Neoplasm Staging Nephrology. Urinary tract diseases Oxidative Stress prostate cancer Prostatic Hyperplasia - immunology Prostatic Hyperplasia - physiopathology Prostatic Neoplasms - immunology Prostatic Neoplasms - physiopathology retinol systemic inflammatory response Tumors Tumors of the urinary system Urinary tract. Prostate gland α‐tocopherol |
| title | Vitamin antioxidants, lipid peroxidation and the systemic inflammatory response in patients with prostate cancer |
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