Analytic Insights Into the Population Level Impact of Imperfect Prophylactic HIV Vaccines

The population level implications of imperfect HIV vaccines were studied using a mathematical model. A criterion for determining the utility of a vaccine at the population level is introduced, and 2 useful summary measures, namely, vaccine utility (ϕ) and vaccine infection fitness (ψ), are derived a...

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Veröffentlicht in:	Journal of acquired immune deficiency syndromes (1999) 2007-08, Vol.45 (4), p.454-467
Hauptverfasser:	Abu-Raddad, Laith J, Boily, Marie-Claude, Self, Steve, Longini, Ira M
Format:	Artikel
Sprache:	eng
Schlagworte:	AIDS Vaccines - administration & dosage AIDS Vaccines - therapeutic use AIDS/HIV Biological and medical sciences Disease prevention Effectiveness Fundamental and applied biological sciences. Psychology HIV HIV Infections - epidemiology HIV Infections - prevention & control HIV-1 - immunology HIV-1 - physiology Human immunodeficiency virus Human viral diseases Humans Immunization Incidence Infectious diseases Medical sciences Microbiology Miscellaneous Models, Biological Public Health Risk Assessment Treatment Outcome Vaccination - utilization Vaccines Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies Viral diseases Viral Load Virology
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