Dose-dependent influence of barbiturates but not of propofol on human leukocyte phagocytosis of viable Staphylococcus aureus

OBJECTIVE:Deep sedation with barbiturates or propofol is a standard therapy for patients with critically elevated intracranial pressure. Such patients are prone to infectious complications, especially to pneumonias, which are most commonly caused by Staphylococcus aureus. Although various immunomodu...

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Veröffentlicht in:	Critical care medicine 2006-02, Vol.34 (2), p.478-483
Hauptverfasser:	Ploppa, Annette, Kiefer, Ralph-Thomas, Nohé, Boris, Haeberle, Helene A, Dieterich, Hans-Jürgen, Unertl, Klaus E, Krueger, Wolfgang A
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Anesthetics, Intravenous - administration & dosage Anesthetics, Intravenous - pharmacology Biological and medical sciences Blood coagulation. Blood cells Dose-Response Relationship, Drug Flow Cytometry Fundamental and applied biological sciences. Psychology General aspects, investigation methods, hemostasis, fibrinolysis Humans Hypnotics. Sedatives Intensive care medicine Leukocytes - drug effects Medical sciences Methohexital - administration & dosage Methohexital - pharmacology Molecular and cellular biology Neuropharmacology Phagocytosis - drug effects Pharmacology. Drug treatments Propofol - administration & dosage Propofol - pharmacology Psychology. Psychoanalysis. Psychiatry Psychopharmacology Staphylococcus aureus - drug effects Staphylococcus aureus - metabolism Thiopental - administration & dosage Thiopental - pharmacology
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