DC-SIGN Is a Receptor for Human Herpesvirus 8 on Dendritic Cells and Macrophages

Human herpesvirus 8 (HHV-8) causes Kaposi's sarcoma and pleural effusion lymphoma. In this study, we show that dendritic cell-specific ICAM-3 grabbing nonintegrin (DC-SIGN; CD209) is a receptor for HHV-8 infection of myeloid DCs and macrophages. DC-SIGN was required for virus attachment to thes...

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Veröffentlicht in:	Journal of Immunology 2006-02, Vol.176 (3), p.1741-1749
Hauptverfasser:	Rappocciolo, Giovanna, Jenkins, Frank J, Hensler, Heather R, Piazza, Paolo, Jais, Mariel, Borowski, Luann, Watkins, Simon C, Rinaldo, Charles R., Jr
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Antibodies, Monoclonal - metabolism Cell Adhesion Molecules - genetics Cell Adhesion Molecules - immunology Cell Adhesion Molecules - metabolism Cell Line Cell Line, Transformed Dendritic Cells - metabolism Dendritic Cells - virology Herpesviridae Infections - immunology Herpesvirus 8, Human - metabolism Human herpesvirus 8 Humans Integrin alpha3beta1 - physiology K562 Cells Lectins, C-Type - genetics Lectins, C-Type - immunology Lectins, C-Type - metabolism Macrophages - metabolism Mannans - metabolism Receptors, Cell Surface - genetics Receptors, Cell Surface - immunology Receptors, Cell Surface - metabolism Receptors, Virus - genetics Receptors, Virus - immunology Receptors, Virus - metabolism
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