Long-term effects of early-life dietary L-carnitine on lymphoid organs and immune responses in Leghorn-type chickens
Summary The long‐term effects of supplementing Leghorn‐type chickens with dietary L‐carnitine after hatching for 4 weeks on growth, lymphoid organ weights, humoral and cell‐mediated immune responses were assessed in a 12‐week study. A commercial starter feed supplemented with 0 (control), 100 (LC) o...
Gespeichert in:
| Veröffentlicht in: | Journal of animal physiology and animal nutrition 2006-02, Vol.90 (1-2), p.81-86 |
|---|---|
| Hauptverfasser: | , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 86 |
|---|---|
| container_issue | 1-2 |
| container_start_page | 81 |
| container_title | Journal of animal physiology and animal nutrition |
| container_volume | 90 |
| creator | Deng, K. Wong, C. W. Nolan, J. V. |
| description | Summary
The long‐term effects of supplementing Leghorn‐type chickens with dietary L‐carnitine after hatching for 4 weeks on growth, lymphoid organ weights, humoral and cell‐mediated immune responses were assessed in a 12‐week study. A commercial starter feed supplemented with 0 (control), 100 (LC) or 1000 (HC) mg L‐carnitine/kg was offered to day‐old ISA Brown cockerels for 4 weeks, then all birds were given a commercial pullet grower feed for another 8 weeks. No differences (p > 0.05) in growth rates, feed intake or feed utilisation efficiency existed among the dietary treatments throughout the study. Compared with control birds, HC‐fed birds had a lower (p |
| doi_str_mv | 10.1111/j.1439-0396.2005.00569.x |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_70692161</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>70692161</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4049-d2cfb37a9d3c6c1c4d59f832fdbd769b5cd0318fd10279bdc4e54ffe9ced5d543</originalsourceid><addsrcrecordid>eNqNkMGO0zAQhi0EYsvCKyCfuCXYceLUEheodhdQtCAB4mg59rh1N7GDnYrm7XFptVwZyZqR5_9nNB9CmJKS5ni7L2nNREGY4GVFSFPmx0V5fIJWj42naEUEo0WVP67Qi5T2hNC2Ifw5uqK8rqq2ZSs0d8FvixniiMFa0HPCwWJQcViKwVnAxsGs4oK7Qqvo3ew84ODxsIzTLjiDQ9wqn7DyBrtxPORuhDQFnyBh53EH212IvpiXCbDeOf0APr1Ez6waEry65Gv04_bm--Zj0X25-7R5n1fVpBaFqbTtWauEYZprqmvTCLtmlTW9abnoG20Io2trKKla0RtdQ1PnI4QG05imZtfozXnuFMOvA6RZji5pGAblIRySbAkXFeU0C9dnoY4hpQhWTtGN-WxJiTwRl3t5AitPYOWJuPxLXB6z9fVlx6EfwfwzXhBnwbuz4LcbYPnvwfLz1_tcZHtxtrs0w_HRruKD5C1rG_nz_k5ubr_R7kO1loz9AQMfoMs</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>70692161</pqid></control><display><type>article</type><title>Long-term effects of early-life dietary L-carnitine on lymphoid organs and immune responses in Leghorn-type chickens</title><source>MEDLINE</source><source>Access via Wiley Online Library</source><creator>Deng, K. ; Wong, C. W. ; Nolan, J. V.</creator><creatorcontrib>Deng, K. ; Wong, C. W. ; Nolan, J. V.</creatorcontrib><description>Summary
The long‐term effects of supplementing Leghorn‐type chickens with dietary L‐carnitine after hatching for 4 weeks on growth, lymphoid organ weights, humoral and cell‐mediated immune responses were assessed in a 12‐week study. A commercial starter feed supplemented with 0 (control), 100 (LC) or 1000 (HC) mg L‐carnitine/kg was offered to day‐old ISA Brown cockerels for 4 weeks, then all birds were given a commercial pullet grower feed for another 8 weeks. No differences (p > 0.05) in growth rates, feed intake or feed utilisation efficiency existed among the dietary treatments throughout the study. Compared with control birds, HC‐fed birds had a lower (p < 0.05) thymus weight relative to bodyweight (BW) at Week 4, but a higher (p < 0.05) relative thymus weight at Week 12. A higher (p < 0.05) serum primary antibody response to sheep red blood cells (SRBC) in HC‐fed birds than in the other two groups was also detected at Week 12. Relative spleen or bursa weights and cutaneous responses of toe webs to phytohaemagglutimin (PHA) (an in vivo indicator of cell‐mediated immune responses) did not differ (p > 0.05) among dietary treatments at any time. It is concluded that a short‐term supply of dietary L‐carnitine to a conventional commercial feed after hatching enhanced subsequent humoral immunity in Leghorn‐type chickens. Further study is warranted to confirm such a long‐term effect.</description><identifier>ISSN: 0931-2439</identifier><identifier>EISSN: 1439-0396</identifier><identifier>DOI: 10.1111/j.1439-0396.2005.00569.x</identifier><identifier>PMID: 16422773</identifier><language>eng</language><publisher>Berlin, Germany: Blackwell Verlag GmbH</publisher><subject>Animal Feed ; Animal Nutritional Physiological Phenomena ; Animals ; Antibody Formation - drug effects ; Antibody Formation - physiology ; Bursa of Fabricius - drug effects ; Bursa of Fabricius - physiology ; Carnitine - administration & dosage ; Chickens - growth & development ; Chickens - immunology ; Dose-Response Relationship, Drug ; Immunity, Cellular - drug effects ; Immunity, Cellular - physiology ; Organ Size - drug effects ; Phytohemagglutinins - immunology ; Random Allocation ; Spleen - drug effects ; Spleen - physiology ; Thymus Gland - drug effects ; Thymus Gland - physiology ; Time Factors ; Weight Gain</subject><ispartof>Journal of animal physiology and animal nutrition, 2006-02, Vol.90 (1-2), p.81-86</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4049-d2cfb37a9d3c6c1c4d59f832fdbd769b5cd0318fd10279bdc4e54ffe9ced5d543</citedby><cites>FETCH-LOGICAL-c4049-d2cfb37a9d3c6c1c4d59f832fdbd769b5cd0318fd10279bdc4e54ffe9ced5d543</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1439-0396.2005.00569.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1439-0396.2005.00569.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16422773$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Deng, K.</creatorcontrib><creatorcontrib>Wong, C. W.</creatorcontrib><creatorcontrib>Nolan, J. V.</creatorcontrib><title>Long-term effects of early-life dietary L-carnitine on lymphoid organs and immune responses in Leghorn-type chickens</title><title>Journal of animal physiology and animal nutrition</title><addtitle>J Anim Physiol Anim Nutr (Berl)</addtitle><description>Summary
The long‐term effects of supplementing Leghorn‐type chickens with dietary L‐carnitine after hatching for 4 weeks on growth, lymphoid organ weights, humoral and cell‐mediated immune responses were assessed in a 12‐week study. A commercial starter feed supplemented with 0 (control), 100 (LC) or 1000 (HC) mg L‐carnitine/kg was offered to day‐old ISA Brown cockerels for 4 weeks, then all birds were given a commercial pullet grower feed for another 8 weeks. No differences (p > 0.05) in growth rates, feed intake or feed utilisation efficiency existed among the dietary treatments throughout the study. Compared with control birds, HC‐fed birds had a lower (p < 0.05) thymus weight relative to bodyweight (BW) at Week 4, but a higher (p < 0.05) relative thymus weight at Week 12. A higher (p < 0.05) serum primary antibody response to sheep red blood cells (SRBC) in HC‐fed birds than in the other two groups was also detected at Week 12. Relative spleen or bursa weights and cutaneous responses of toe webs to phytohaemagglutimin (PHA) (an in vivo indicator of cell‐mediated immune responses) did not differ (p > 0.05) among dietary treatments at any time. It is concluded that a short‐term supply of dietary L‐carnitine to a conventional commercial feed after hatching enhanced subsequent humoral immunity in Leghorn‐type chickens. Further study is warranted to confirm such a long‐term effect.</description><subject>Animal Feed</subject><subject>Animal Nutritional Physiological Phenomena</subject><subject>Animals</subject><subject>Antibody Formation - drug effects</subject><subject>Antibody Formation - physiology</subject><subject>Bursa of Fabricius - drug effects</subject><subject>Bursa of Fabricius - physiology</subject><subject>Carnitine - administration & dosage</subject><subject>Chickens - growth & development</subject><subject>Chickens - immunology</subject><subject>Dose-Response Relationship, Drug</subject><subject>Immunity, Cellular - drug effects</subject><subject>Immunity, Cellular - physiology</subject><subject>Organ Size - drug effects</subject><subject>Phytohemagglutinins - immunology</subject><subject>Random Allocation</subject><subject>Spleen - drug effects</subject><subject>Spleen - physiology</subject><subject>Thymus Gland - drug effects</subject><subject>Thymus Gland - physiology</subject><subject>Time Factors</subject><subject>Weight Gain</subject><issn>0931-2439</issn><issn>1439-0396</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkMGO0zAQhi0EYsvCKyCfuCXYceLUEheodhdQtCAB4mg59rh1N7GDnYrm7XFptVwZyZqR5_9nNB9CmJKS5ni7L2nNREGY4GVFSFPmx0V5fIJWj42naEUEo0WVP67Qi5T2hNC2Ifw5uqK8rqq2ZSs0d8FvixniiMFa0HPCwWJQcViKwVnAxsGs4oK7Qqvo3ew84ODxsIzTLjiDQ9wqn7DyBrtxPORuhDQFnyBh53EH212IvpiXCbDeOf0APr1Ez6waEry65Gv04_bm--Zj0X25-7R5n1fVpBaFqbTtWauEYZprqmvTCLtmlTW9abnoG20Io2trKKla0RtdQ1PnI4QG05imZtfozXnuFMOvA6RZji5pGAblIRySbAkXFeU0C9dnoY4hpQhWTtGN-WxJiTwRl3t5AitPYOWJuPxLXB6z9fVlx6EfwfwzXhBnwbuz4LcbYPnvwfLz1_tcZHtxtrs0w_HRruKD5C1rG_nz_k5ubr_R7kO1loz9AQMfoMs</recordid><startdate>200602</startdate><enddate>200602</enddate><creator>Deng, K.</creator><creator>Wong, C. W.</creator><creator>Nolan, J. V.</creator><general>Blackwell Verlag GmbH</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200602</creationdate><title>Long-term effects of early-life dietary L-carnitine on lymphoid organs and immune responses in Leghorn-type chickens</title><author>Deng, K. ; Wong, C. W. ; Nolan, J. V.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4049-d2cfb37a9d3c6c1c4d59f832fdbd769b5cd0318fd10279bdc4e54ffe9ced5d543</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Animal Feed</topic><topic>Animal Nutritional Physiological Phenomena</topic><topic>Animals</topic><topic>Antibody Formation - drug effects</topic><topic>Antibody Formation - physiology</topic><topic>Bursa of Fabricius - drug effects</topic><topic>Bursa of Fabricius - physiology</topic><topic>Carnitine - administration & dosage</topic><topic>Chickens - growth & development</topic><topic>Chickens - immunology</topic><topic>Dose-Response Relationship, Drug</topic><topic>Immunity, Cellular - drug effects</topic><topic>Immunity, Cellular - physiology</topic><topic>Organ Size - drug effects</topic><topic>Phytohemagglutinins - immunology</topic><topic>Random Allocation</topic><topic>Spleen - drug effects</topic><topic>Spleen - physiology</topic><topic>Thymus Gland - drug effects</topic><topic>Thymus Gland - physiology</topic><topic>Time Factors</topic><topic>Weight Gain</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Deng, K.</creatorcontrib><creatorcontrib>Wong, C. W.</creatorcontrib><creatorcontrib>Nolan, J. V.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of animal physiology and animal nutrition</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Deng, K.</au><au>Wong, C. W.</au><au>Nolan, J. V.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Long-term effects of early-life dietary L-carnitine on lymphoid organs and immune responses in Leghorn-type chickens</atitle><jtitle>Journal of animal physiology and animal nutrition</jtitle><addtitle>J Anim Physiol Anim Nutr (Berl)</addtitle><date>2006-02</date><risdate>2006</risdate><volume>90</volume><issue>1-2</issue><spage>81</spage><epage>86</epage><pages>81-86</pages><issn>0931-2439</issn><eissn>1439-0396</eissn><abstract>Summary
The long‐term effects of supplementing Leghorn‐type chickens with dietary L‐carnitine after hatching for 4 weeks on growth, lymphoid organ weights, humoral and cell‐mediated immune responses were assessed in a 12‐week study. A commercial starter feed supplemented with 0 (control), 100 (LC) or 1000 (HC) mg L‐carnitine/kg was offered to day‐old ISA Brown cockerels for 4 weeks, then all birds were given a commercial pullet grower feed for another 8 weeks. No differences (p > 0.05) in growth rates, feed intake or feed utilisation efficiency existed among the dietary treatments throughout the study. Compared with control birds, HC‐fed birds had a lower (p < 0.05) thymus weight relative to bodyweight (BW) at Week 4, but a higher (p < 0.05) relative thymus weight at Week 12. A higher (p < 0.05) serum primary antibody response to sheep red blood cells (SRBC) in HC‐fed birds than in the other two groups was also detected at Week 12. Relative spleen or bursa weights and cutaneous responses of toe webs to phytohaemagglutimin (PHA) (an in vivo indicator of cell‐mediated immune responses) did not differ (p > 0.05) among dietary treatments at any time. It is concluded that a short‐term supply of dietary L‐carnitine to a conventional commercial feed after hatching enhanced subsequent humoral immunity in Leghorn‐type chickens. Further study is warranted to confirm such a long‐term effect.</abstract><cop>Berlin, Germany</cop><pub>Blackwell Verlag GmbH</pub><pmid>16422773</pmid><doi>10.1111/j.1439-0396.2005.00569.x</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0931-2439 |
| ispartof | Journal of animal physiology and animal nutrition, 2006-02, Vol.90 (1-2), p.81-86 |
| issn | 0931-2439 1439-0396 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_70692161 |
| source | MEDLINE; Access via Wiley Online Library |
| subjects | Animal Feed Animal Nutritional Physiological Phenomena Animals Antibody Formation - drug effects Antibody Formation - physiology Bursa of Fabricius - drug effects Bursa of Fabricius - physiology Carnitine - administration & dosage Chickens - growth & development Chickens - immunology Dose-Response Relationship, Drug Immunity, Cellular - drug effects Immunity, Cellular - physiology Organ Size - drug effects Phytohemagglutinins - immunology Random Allocation Spleen - drug effects Spleen - physiology Thymus Gland - drug effects Thymus Gland - physiology Time Factors Weight Gain |
| title | Long-term effects of early-life dietary L-carnitine on lymphoid organs and immune responses in Leghorn-type chickens |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-22T09%3A40%3A19IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Long-term%20effects%20of%20early-life%20dietary%20L-carnitine%20on%20lymphoid%20organs%20and%20immune%20responses%20in%20Leghorn-type%20chickens&rft.jtitle=Journal%20of%20animal%20physiology%20and%20animal%20nutrition&rft.au=Deng,%20K.&rft.date=2006-02&rft.volume=90&rft.issue=1-2&rft.spage=81&rft.epage=86&rft.pages=81-86&rft.issn=0931-2439&rft.eissn=1439-0396&rft_id=info:doi/10.1111/j.1439-0396.2005.00569.x&rft_dat=%3Cproquest_cross%3E70692161%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=70692161&rft_id=info:pmid/16422773&rfr_iscdi=true |