Diet and Murine Atherosclerosis
Lipid-enriched diets are often used to induce or accelerate the rate of atherosclerotic lesion development in murine models of atherosclerosis. It appears that the induction of persistent hypercholesterolemia to levels >≈300 mg/dL is required for the development of experimental atherosclerosis in...
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| Veröffentlicht in: | Arteriosclerosis, thrombosis, and vascular biology thrombosis, and vascular biology, 2006-02, Vol.26 (2), p.242-249 |
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| container_title | Arteriosclerosis, thrombosis, and vascular biology |
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| creator | Getz, Godfrey S Reardon, Catherine A |
| description | Lipid-enriched diets are often used to induce or accelerate the rate of atherosclerotic lesion development in murine models of atherosclerosis. It appears that the induction of persistent hypercholesterolemia to levels >≈300 mg/dL is required for the development of experimental atherosclerosis in the mouse. A variety of different diets have been used that vary in the level of cholesterol, the level and type of fatty acid, and the absence or presence of cholate. Each of these components as well as the protein source has been shown to influence lipoprotein level and/or atherosclerosis, with dietary cholesterol being the major proatherogenic component. In some instances the effects of these components on the expression of hepatic genes relevant to lipid homeostasis has been observed. An appreciation of the effect of the differences in diet composition on these processes is important to compare results from different atherosclerosis studies, so the composition of the diets used should always be reported or referenced. Cholate should not be used unless its effects are being specifically investigated. |
| doi_str_mv | 10.1161/01.ATV.0000201071.49029.17 |
| format | Article |
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It appears that the induction of persistent hypercholesterolemia to levels >≈300 mg/dL is required for the development of experimental atherosclerosis in the mouse. A variety of different diets have been used that vary in the level of cholesterol, the level and type of fatty acid, and the absence or presence of cholate. Each of these components as well as the protein source has been shown to influence lipoprotein level and/or atherosclerosis, with dietary cholesterol being the major proatherogenic component. In some instances the effects of these components on the expression of hepatic genes relevant to lipid homeostasis has been observed. An appreciation of the effect of the differences in diet composition on these processes is important to compare results from different atherosclerosis studies, so the composition of the diets used should always be reported or referenced. 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It appears that the induction of persistent hypercholesterolemia to levels >≈300 mg/dL is required for the development of experimental atherosclerosis in the mouse. A variety of different diets have been used that vary in the level of cholesterol, the level and type of fatty acid, and the absence or presence of cholate. Each of these components as well as the protein source has been shown to influence lipoprotein level and/or atherosclerosis, with dietary cholesterol being the major proatherogenic component. In some instances the effects of these components on the expression of hepatic genes relevant to lipid homeostasis has been observed. An appreciation of the effect of the differences in diet composition on these processes is important to compare results from different atherosclerosis studies, so the composition of the diets used should always be reported or referenced. Cholate should not be used unless its effects are being specifically investigated.</description><subject>Animal Feed</subject><subject>Animals</subject><subject>Associated diseases and complications</subject><subject>Atherosclerosis (general aspects, experimental research)</subject><subject>Atherosclerosis - etiology</subject><subject>Atherosclerosis - physiopathology</subject><subject>Biological and medical sciences</subject><subject>Blood and lymphatic vessels</subject><subject>Cardiology. Vascular system</subject><subject>Cardiovascular system</subject><subject>Diabetes. Impaired glucose tolerance</subject><subject>Diet, Atherogenic</subject><subject>Disease Models, Animal</subject><subject>Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous</subject><subject>Endocrine pancreas. Apud cells (diseases)</subject><subject>Endocrinopathies</subject><subject>Hypercholesterolemia - etiology</subject><subject>Hypercholesterolemia - physiopathology</subject><subject>Medical sciences</subject><subject>Mice</subject><subject>Pharmacology. Drug treatments</subject><subject>Vasodilator agents. Cerebral vasodilators</subject><issn>1079-5642</issn><issn>1524-4636</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkFtrGzEQhUVpaBKnfyExgfZttzNa3bZvJm0u4NIXp69ClmbxpuvdVNol5N9Xjg2G6GEkxDdzzhzGrhFKRIXfAMvF6k8J-XBA0FiKGnhdov7AzlByUQhVqY_5DboupBL8lJ2n9JR5wTl8YqeoKl0p0Gfs6kdL49z1Yf5rim1P88W4oTgk3-1qmy7YSeO6RJ8P94w93v5c3dwXy993DzeLZeGlBlF4RUBKNV5WoUZdEQoKUmoeGtfotfFZsalctUapQzC1EbL2GrUPxlDAdTVjX_dzn-Pwb6I02m2bPHWd62mYktWgajTKZPD6Hfg0TLHP3izP6xmjdJ2h73vI5yVSpMY-x3br4qtFsLsMLaDNGdpjhvYtQ5u9z9jlQWFabykcWw-hZeDLAXDJu66JrvdtOnJaCFRmZ1XsuZehGymmv930QtFuyHXjZict8jhZcACVTQAU8Pb3HzWihzI</recordid><startdate>200602</startdate><enddate>200602</enddate><creator>Getz, Godfrey S</creator><creator>Reardon, Catherine A</creator><general>American Heart Association, Inc</general><general>Lippincott</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>7X8</scope></search><sort><creationdate>200602</creationdate><title>Diet and Murine Atherosclerosis</title><author>Getz, Godfrey S ; Reardon, Catherine A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5704-c6e0e66fc53d9173e14ed5572dfaf7b8c163f3a3b157dd898459c717cd88ed1b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Animal Feed</topic><topic>Animals</topic><topic>Associated diseases and complications</topic><topic>Atherosclerosis (general aspects, experimental research)</topic><topic>Atherosclerosis - etiology</topic><topic>Atherosclerosis - physiopathology</topic><topic>Biological and medical sciences</topic><topic>Blood and lymphatic vessels</topic><topic>Cardiology. Vascular system</topic><topic>Cardiovascular system</topic><topic>Diabetes. Impaired glucose tolerance</topic><topic>Diet, Atherogenic</topic><topic>Disease Models, Animal</topic><topic>Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous</topic><topic>Endocrine pancreas. Apud cells (diseases)</topic><topic>Endocrinopathies</topic><topic>Hypercholesterolemia - etiology</topic><topic>Hypercholesterolemia - physiopathology</topic><topic>Medical sciences</topic><topic>Mice</topic><topic>Pharmacology. Drug treatments</topic><topic>Vasodilator agents. Cerebral vasodilators</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Getz, Godfrey S</creatorcontrib><creatorcontrib>Reardon, Catherine A</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Arteriosclerosis, thrombosis, and vascular biology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Getz, Godfrey S</au><au>Reardon, Catherine A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Diet and Murine Atherosclerosis</atitle><jtitle>Arteriosclerosis, thrombosis, and vascular biology</jtitle><addtitle>Arterioscler Thromb Vasc Biol</addtitle><date>2006-02</date><risdate>2006</risdate><volume>26</volume><issue>2</issue><spage>242</spage><epage>249</epage><pages>242-249</pages><issn>1079-5642</issn><eissn>1524-4636</eissn><coden>ATVBFA</coden><abstract>Lipid-enriched diets are often used to induce or accelerate the rate of atherosclerotic lesion development in murine models of atherosclerosis. It appears that the induction of persistent hypercholesterolemia to levels >≈300 mg/dL is required for the development of experimental atherosclerosis in the mouse. A variety of different diets have been used that vary in the level of cholesterol, the level and type of fatty acid, and the absence or presence of cholate. Each of these components as well as the protein source has been shown to influence lipoprotein level and/or atherosclerosis, with dietary cholesterol being the major proatherogenic component. In some instances the effects of these components on the expression of hepatic genes relevant to lipid homeostasis has been observed. An appreciation of the effect of the differences in diet composition on these processes is important to compare results from different atherosclerosis studies, so the composition of the diets used should always be reported or referenced. Cholate should not be used unless its effects are being specifically investigated.</abstract><cop>Philadelphia, PA</cop><cop>Hagerstown, MD</cop><pub>American Heart Association, Inc</pub><pmid>16373607</pmid><doi>10.1161/01.ATV.0000201071.49029.17</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 1079-5642 |
| ispartof | Arteriosclerosis, thrombosis, and vascular biology, 2006-02, Vol.26 (2), p.242-249 |
| issn | 1079-5642 1524-4636 |
| language | eng |
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| source | MEDLINE; Alma/SFX Local Collection; Journals@Ovid Complete |
| subjects | Animal Feed Animals Associated diseases and complications Atherosclerosis (general aspects, experimental research) Atherosclerosis - etiology Atherosclerosis - physiopathology Biological and medical sciences Blood and lymphatic vessels Cardiology. Vascular system Cardiovascular system Diabetes. Impaired glucose tolerance Diet, Atherogenic Disease Models, Animal Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous Endocrine pancreas. Apud cells (diseases) Endocrinopathies Hypercholesterolemia - etiology Hypercholesterolemia - physiopathology Medical sciences Mice Pharmacology. Drug treatments Vasodilator agents. Cerebral vasodilators |
| title | Diet and Murine Atherosclerosis |
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