The effect of dexamethasone on postoperative vomiting and oral intake after adenotonsillectomy
Summary Objective Vomiting is one of the most important postoperative complications of adenotonsillectomy. This study was designed to determine the effectiveness of preoperative intravenous dexamethasone on postoperative emesis. Methods In a double-blind, placebo-controlled clinical trial, 100 patie...
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| Veröffentlicht in: | International journal of pediatric otorhinolaryngology 2007-08, Vol.71 (8), p.1235-1238 |
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| container_title | International journal of pediatric otorhinolaryngology |
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| creator | Fazel, M.R Yegane-Moghaddam, A Forghani, Z Aghadoost, D Mahdian, M Fakharian, E |
| description | Summary Objective Vomiting is one of the most important postoperative complications of adenotonsillectomy. This study was designed to determine the effectiveness of preoperative intravenous dexamethasone on postoperative emesis. Methods In a double-blind, placebo-controlled clinical trial, 100 patients aged 5–15 years, ASA classes I and II were randomly selected to receive either 0.5 mg/kg IV dexamethasone ( n = 50), as study group or an equivalent volume of saline preoperatively, as control group. The anesthetic regimen and surgical procedures were standardized for all patients. The incidence of early and late vomiting, the time to first oral intake and duration of intravenous hydration were compared in both groups. Results Data analysis showed that the overall incidence of early and late vomiting was significantly lesser in dexamehasone group than the control one. The time to first oral intake and duration of IV therapy were also significantly shorter in dexamethasone group. Conclusion A single dose of dexamethasone significantly decreased the incidence of postoperative vomiting in early and late recovery phase and shortened the time to first oral intake and the duration of IV therapy. |
| doi_str_mv | 10.1016/j.ijporl.2007.04.015 |
| format | Article |
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This study was designed to determine the effectiveness of preoperative intravenous dexamethasone on postoperative emesis. Methods In a double-blind, placebo-controlled clinical trial, 100 patients aged 5–15 years, ASA classes I and II were randomly selected to receive either 0.5 mg/kg IV dexamethasone ( n = 50), as study group or an equivalent volume of saline preoperatively, as control group. The anesthetic regimen and surgical procedures were standardized for all patients. The incidence of early and late vomiting, the time to first oral intake and duration of intravenous hydration were compared in both groups. Results Data analysis showed that the overall incidence of early and late vomiting was significantly lesser in dexamehasone group than the control one. The time to first oral intake and duration of IV therapy were also significantly shorter in dexamethasone group. Conclusion A single dose of dexamethasone significantly decreased the incidence of postoperative vomiting in early and late recovery phase and shortened the time to first oral intake and the duration of IV therapy.</description><identifier>ISSN: 0165-5876</identifier><identifier>EISSN: 1872-8464</identifier><identifier>DOI: 10.1016/j.ijporl.2007.04.015</identifier><identifier>PMID: 17544156</identifier><language>eng</language><publisher>Ireland: Elsevier Ireland Ltd</publisher><subject>Adenoidectomy - adverse effects ; Adenotoncillectomy ; Adolescent ; Antiemetics - therapeutic use ; Child ; Child, Preschool ; Dexamethasone ; Dexamethasone - therapeutic use ; Double-Blind Method ; Eating ; Female ; Humans ; Male ; Oral intake ; Otolaryngology ; Pediatrics ; Postoperative Nausea and Vomiting - prevention & control ; Tonsillectomy - adverse effects ; Vomiting</subject><ispartof>International journal of pediatric otorhinolaryngology, 2007-08, Vol.71 (8), p.1235-1238</ispartof><rights>Elsevier Ireland Ltd</rights><rights>2007 Elsevier Ireland Ltd</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c440t-e7b3a9232b25bdc5b6d0777d254899e0d0de0e07d926174ad145f0038b356633</citedby><cites>FETCH-LOGICAL-c440t-e7b3a9232b25bdc5b6d0777d254899e0d0de0e07d926174ad145f0038b356633</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0165587607001905$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17544156$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Fazel, M.R</creatorcontrib><creatorcontrib>Yegane-Moghaddam, A</creatorcontrib><creatorcontrib>Forghani, Z</creatorcontrib><creatorcontrib>Aghadoost, D</creatorcontrib><creatorcontrib>Mahdian, M</creatorcontrib><creatorcontrib>Fakharian, E</creatorcontrib><title>The effect of dexamethasone on postoperative vomiting and oral intake after adenotonsillectomy</title><title>International journal of pediatric otorhinolaryngology</title><addtitle>Int J Pediatr Otorhinolaryngol</addtitle><description>Summary Objective Vomiting is one of the most important postoperative complications of adenotonsillectomy. This study was designed to determine the effectiveness of preoperative intravenous dexamethasone on postoperative emesis. Methods In a double-blind, placebo-controlled clinical trial, 100 patients aged 5–15 years, ASA classes I and II were randomly selected to receive either 0.5 mg/kg IV dexamethasone ( n = 50), as study group or an equivalent volume of saline preoperatively, as control group. The anesthetic regimen and surgical procedures were standardized for all patients. The incidence of early and late vomiting, the time to first oral intake and duration of intravenous hydration were compared in both groups. Results Data analysis showed that the overall incidence of early and late vomiting was significantly lesser in dexamehasone group than the control one. The time to first oral intake and duration of IV therapy were also significantly shorter in dexamethasone group. Conclusion A single dose of dexamethasone significantly decreased the incidence of postoperative vomiting in early and late recovery phase and shortened the time to first oral intake and the duration of IV therapy.</description><subject>Adenoidectomy - adverse effects</subject><subject>Adenotoncillectomy</subject><subject>Adolescent</subject><subject>Antiemetics - therapeutic use</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Dexamethasone</subject><subject>Dexamethasone - therapeutic use</subject><subject>Double-Blind Method</subject><subject>Eating</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Oral intake</subject><subject>Otolaryngology</subject><subject>Pediatrics</subject><subject>Postoperative Nausea and Vomiting - prevention & control</subject><subject>Tonsillectomy - adverse effects</subject><subject>Vomiting</subject><issn>0165-5876</issn><issn>1872-8464</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU1r3DAQhkVpabZJ_kEpOvVmd2Trw74USugXBHLInitka9zIsSVX0i7df1-bXSj00tNcnnmHeV5C3jIoGTD5YSzduIQ4lRWAKoGXwMQLsmONqoqGS_6S7FZMFKJR8oq8SWkEYAqEeE2umBKcMyF35Mf-CSkOA_aZhoFa_G1mzE8mBY80eLqElMOC0WR3RHoMs8vO_6TGWxqimajz2TwjNUPGSI1FH3LwyU3TGhjm0w15NZgp4e1lXpP9l8_7u2_F_cPX73ef7ouec8gFqq42bVVXXSU624tOWlBK2Urwpm0RLFgEBGXbSjLFjWVcDAB109VCyrq-Ju_PsUsMvw6Ysp5d6nGajMdwSFqBbFnVbCA_g30MKUUc9BLdbOJJM9CbVj3qs1a9adXA9ap1XXt3yT90M9q_SxePK_DxDOD65NFh1Kl36Hu0Lq4mtA3ufxf-Degn511vpmc8YRrDIfpVoGY6VRr041bt1iyotdUWRP0HweGg4Q</recordid><startdate>20070801</startdate><enddate>20070801</enddate><creator>Fazel, M.R</creator><creator>Yegane-Moghaddam, A</creator><creator>Forghani, Z</creator><creator>Aghadoost, D</creator><creator>Mahdian, M</creator><creator>Fakharian, E</creator><general>Elsevier Ireland Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>8BM</scope></search><sort><creationdate>20070801</creationdate><title>The effect of dexamethasone on postoperative vomiting and oral intake after adenotonsillectomy</title><author>Fazel, M.R ; Yegane-Moghaddam, A ; Forghani, Z ; Aghadoost, D ; Mahdian, M ; Fakharian, E</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c440t-e7b3a9232b25bdc5b6d0777d254899e0d0de0e07d926174ad145f0038b356633</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Adenoidectomy - adverse effects</topic><topic>Adenotoncillectomy</topic><topic>Adolescent</topic><topic>Antiemetics - therapeutic use</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Dexamethasone</topic><topic>Dexamethasone - therapeutic use</topic><topic>Double-Blind Method</topic><topic>Eating</topic><topic>Female</topic><topic>Humans</topic><topic>Male</topic><topic>Oral intake</topic><topic>Otolaryngology</topic><topic>Pediatrics</topic><topic>Postoperative Nausea and Vomiting - prevention & control</topic><topic>Tonsillectomy - adverse effects</topic><topic>Vomiting</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Fazel, M.R</creatorcontrib><creatorcontrib>Yegane-Moghaddam, A</creatorcontrib><creatorcontrib>Forghani, Z</creatorcontrib><creatorcontrib>Aghadoost, D</creatorcontrib><creatorcontrib>Mahdian, M</creatorcontrib><creatorcontrib>Fakharian, E</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>ComDisDome</collection><jtitle>International journal of pediatric otorhinolaryngology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Fazel, M.R</au><au>Yegane-Moghaddam, A</au><au>Forghani, Z</au><au>Aghadoost, D</au><au>Mahdian, M</au><au>Fakharian, E</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The effect of dexamethasone on postoperative vomiting and oral intake after adenotonsillectomy</atitle><jtitle>International journal of pediatric otorhinolaryngology</jtitle><addtitle>Int J Pediatr Otorhinolaryngol</addtitle><date>2007-08-01</date><risdate>2007</risdate><volume>71</volume><issue>8</issue><spage>1235</spage><epage>1238</epage><pages>1235-1238</pages><issn>0165-5876</issn><eissn>1872-8464</eissn><abstract>Summary Objective Vomiting is one of the most important postoperative complications of adenotonsillectomy. This study was designed to determine the effectiveness of preoperative intravenous dexamethasone on postoperative emesis. Methods In a double-blind, placebo-controlled clinical trial, 100 patients aged 5–15 years, ASA classes I and II were randomly selected to receive either 0.5 mg/kg IV dexamethasone ( n = 50), as study group or an equivalent volume of saline preoperatively, as control group. The anesthetic regimen and surgical procedures were standardized for all patients. The incidence of early and late vomiting, the time to first oral intake and duration of intravenous hydration were compared in both groups. Results Data analysis showed that the overall incidence of early and late vomiting was significantly lesser in dexamehasone group than the control one. The time to first oral intake and duration of IV therapy were also significantly shorter in dexamethasone group. Conclusion A single dose of dexamethasone significantly decreased the incidence of postoperative vomiting in early and late recovery phase and shortened the time to first oral intake and the duration of IV therapy.</abstract><cop>Ireland</cop><pub>Elsevier Ireland Ltd</pub><pmid>17544156</pmid><doi>10.1016/j.ijporl.2007.04.015</doi><tpages>4</tpages></addata></record> |
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| subjects | Adenoidectomy - adverse effects Adenotoncillectomy Adolescent Antiemetics - therapeutic use Child Child, Preschool Dexamethasone Dexamethasone - therapeutic use Double-Blind Method Eating Female Humans Male Oral intake Otolaryngology Pediatrics Postoperative Nausea and Vomiting - prevention & control Tonsillectomy - adverse effects Vomiting |
| title | The effect of dexamethasone on postoperative vomiting and oral intake after adenotonsillectomy |
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