Role of the 5[acute accent] [rightward arrow] 3[acute accent] exonuclease and Klenow fragment of Escherichia coli DNA polymerase I in base mismatch repair

We have previously demonstrated that the Escherichia coli strain mutS ΔpolA had a higher rate of transition and minus frameshift mutations than mutS or ΔpolA strains. We argued that DNA polymerase I (PolI) corrects transition mismatches. PolI, encoded by the polA gene, possesses Klenow and 5[acute a...

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