Thyroid function after bone marrow transplantation : Possible association between immune-mediated thyrotoxicosis and hypothyroidism
Thyroid dysfunction after bone marrow transplantation (BMT) has been investigated in many studies, and most posttransplant thyroid disorders are now recognized as a late complication of transplantation. However, these studies mainly focused on late thyroid function after BMT, and we have little info...
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| Veröffentlicht in: | Transplantation 2001-02, Vol.71 (3), p.406-411 |
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| creator | KAMI, Masahiro TANAKA, Yuji CHIBA, Shigeru MATSUMURA, Tomoko MACHIDA, Utako KANDA, Yoshinobu NAKAGAWA, Keiichi MITSUHASHI, Tomoaki HIRAI, Hisamaru |
| description | Thyroid dysfunction after bone marrow transplantation (BMT) has been investigated in many studies, and most posttransplant thyroid disorders are now recognized as a late complication of transplantation. However, these studies mainly focused on late thyroid function after BMT, and we have little information on early changes of thyroid function after BMT.
We prospectively investigated thyroid function in 57 patients receiving BMT. Serum thyroid-stimulating hormone, free triiodothyronine, and free thyroxine levels were determined at least monthly in the first 3 months, once between 3 and 12 months and once in the second year after BMT.
During the first 6 months after BMT, 24 and 7 patients were diagnosed as having euthyroid sick syndrome (ETS) and thyrotoxicosis, respectively. Of the 52 patients alive 1 year after transplantation, 9 patients were still diagnosed as having ETS, and 8 patients developed hypothyroidism. Patients with thyrotoxicosis showed similar characteristics, and the high incidence of thyrotoxicosis after BMT is a novel finding. The median for the onset of thyrotoxicosis was day 111 after transplantation. Thyrotoxicosis was transient in all of the patients, but in seven patients hypothyroidism followed, the median onset at 12 months after BMT. Serum thyroglobulin levels were elevated in five patients, and antibodies autoreactive to the thyroid gland were detected in seven patients.
Thyrotoxicosis may be a distinct clinical entity of thyroid dysfunction after BMT and may serve to predict the development of hypothyroidism. Immune-mediated thyroid injury may contribute to the development of posttransplant hypothyroidism. |
| doi_str_mv | 10.1097/00007890-200102150-00012 |
| format | Article |
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We prospectively investigated thyroid function in 57 patients receiving BMT. Serum thyroid-stimulating hormone, free triiodothyronine, and free thyroxine levels were determined at least monthly in the first 3 months, once between 3 and 12 months and once in the second year after BMT.
During the first 6 months after BMT, 24 and 7 patients were diagnosed as having euthyroid sick syndrome (ETS) and thyrotoxicosis, respectively. Of the 52 patients alive 1 year after transplantation, 9 patients were still diagnosed as having ETS, and 8 patients developed hypothyroidism. Patients with thyrotoxicosis showed similar characteristics, and the high incidence of thyrotoxicosis after BMT is a novel finding. The median for the onset of thyrotoxicosis was day 111 after transplantation. Thyrotoxicosis was transient in all of the patients, but in seven patients hypothyroidism followed, the median onset at 12 months after BMT. Serum thyroglobulin levels were elevated in five patients, and antibodies autoreactive to the thyroid gland were detected in seven patients.
Thyrotoxicosis may be a distinct clinical entity of thyroid dysfunction after BMT and may serve to predict the development of hypothyroidism. Immune-mediated thyroid injury may contribute to the development of posttransplant hypothyroidism.</description><identifier>ISSN: 0041-1337</identifier><identifier>EISSN: 1534-6080</identifier><identifier>DOI: 10.1097/00007890-200102150-00012</identifier><identifier>PMID: 11233902</identifier><identifier>CODEN: TRPLAU</identifier><language>eng</language><publisher>Hagerstown, MD: Lippincott</publisher><subject>Adolescent ; Adult ; Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy ; Biological and medical sciences ; Bone Marrow Transplantation - adverse effects ; Bone Marrow Transplantation - mortality ; Bone marrow, stem cells transplantation. Graft versus host reaction ; Euthyroid Sick Syndromes - etiology ; Female ; Humans ; Incidence ; Male ; Medical sciences ; Middle Aged ; Prognosis ; Survival Rate ; Thyroglobulin - blood ; Thyroid Gland - physiology ; Thyrotoxicosis - epidemiology ; Thyrotoxicosis - etiology ; Thyrotoxicosis - immunology ; Transfusions. Complications. Transfusion reactions. Cell and gene therapy</subject><ispartof>Transplantation, 2001-02, Vol.71 (3), p.406-411</ispartof><rights>2001 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1041458$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11233902$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>KAMI, Masahiro</creatorcontrib><creatorcontrib>TANAKA, Yuji</creatorcontrib><creatorcontrib>CHIBA, Shigeru</creatorcontrib><creatorcontrib>MATSUMURA, Tomoko</creatorcontrib><creatorcontrib>MACHIDA, Utako</creatorcontrib><creatorcontrib>KANDA, Yoshinobu</creatorcontrib><creatorcontrib>NAKAGAWA, Keiichi</creatorcontrib><creatorcontrib>MITSUHASHI, Tomoaki</creatorcontrib><creatorcontrib>HIRAI, Hisamaru</creatorcontrib><title>Thyroid function after bone marrow transplantation : Possible association between immune-mediated thyrotoxicosis and hypothyroidism</title><title>Transplantation</title><addtitle>Transplantation</addtitle><description>Thyroid dysfunction after bone marrow transplantation (BMT) has been investigated in many studies, and most posttransplant thyroid disorders are now recognized as a late complication of transplantation. However, these studies mainly focused on late thyroid function after BMT, and we have little information on early changes of thyroid function after BMT.
We prospectively investigated thyroid function in 57 patients receiving BMT. Serum thyroid-stimulating hormone, free triiodothyronine, and free thyroxine levels were determined at least monthly in the first 3 months, once between 3 and 12 months and once in the second year after BMT.
During the first 6 months after BMT, 24 and 7 patients were diagnosed as having euthyroid sick syndrome (ETS) and thyrotoxicosis, respectively. Of the 52 patients alive 1 year after transplantation, 9 patients were still diagnosed as having ETS, and 8 patients developed hypothyroidism. Patients with thyrotoxicosis showed similar characteristics, and the high incidence of thyrotoxicosis after BMT is a novel finding. The median for the onset of thyrotoxicosis was day 111 after transplantation. Thyrotoxicosis was transient in all of the patients, but in seven patients hypothyroidism followed, the median onset at 12 months after BMT. Serum thyroglobulin levels were elevated in five patients, and antibodies autoreactive to the thyroid gland were detected in seven patients.
Thyrotoxicosis may be a distinct clinical entity of thyroid dysfunction after BMT and may serve to predict the development of hypothyroidism. Immune-mediated thyroid injury may contribute to the development of posttransplant hypothyroidism.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</subject><subject>Biological and medical sciences</subject><subject>Bone Marrow Transplantation - adverse effects</subject><subject>Bone Marrow Transplantation - mortality</subject><subject>Bone marrow, stem cells transplantation. Graft versus host reaction</subject><subject>Euthyroid Sick Syndromes - etiology</subject><subject>Female</subject><subject>Humans</subject><subject>Incidence</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Prognosis</subject><subject>Survival Rate</subject><subject>Thyroglobulin - blood</subject><subject>Thyroid Gland - physiology</subject><subject>Thyrotoxicosis - epidemiology</subject><subject>Thyrotoxicosis - etiology</subject><subject>Thyrotoxicosis - immunology</subject><subject>Transfusions. Complications. Transfusion reactions. Cell and gene therapy</subject><issn>0041-1337</issn><issn>1534-6080</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkUtLAzEUhYMotlb_gmQh7kbzmLzcSfEFBV3UdUkmGRqZmYyTDLVr_7jRVlx6NxfO_biXcy4AEKMrjJS4RrmEVKggCGFEMENFVjA5AFPMaFlwJNEhmCJU4gJTKibgJMa3jDAqxDGYYEwoVYhMwedyvR2Ct7Aeuyr50EFdJzdAEzoHWz0MYQPToLvYN7pL-oe4gS8hRm8aB3WMofI72bi0ca6Dvm3HzhWts3ngLEzfF1L48FWIPkLdWbje9iHtDvvYnoKjWjfRne37DLze3y3nj8Xi-eFpfrsoeqxUKjTF2hhphHPMyJJIInmNLFNEiZowUyHBKcNYGEtqUioiK-u0xWVJuOLa0hm43O3th_A-uphWrY-Va7IzF8a4EohLySX_F8RCMk54mcHzPTia7HfVDz5ntl395puBiz2gY6WbOidZ-fjH5QeVTNIvkaSOZQ</recordid><startdate>20010215</startdate><enddate>20010215</enddate><creator>KAMI, Masahiro</creator><creator>TANAKA, Yuji</creator><creator>CHIBA, Shigeru</creator><creator>MATSUMURA, Tomoko</creator><creator>MACHIDA, Utako</creator><creator>KANDA, Yoshinobu</creator><creator>NAKAGAWA, Keiichi</creator><creator>MITSUHASHI, Tomoaki</creator><creator>HIRAI, Hisamaru</creator><general>Lippincott</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7T5</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>20010215</creationdate><title>Thyroid function after bone marrow transplantation : Possible association between immune-mediated thyrotoxicosis and hypothyroidism</title><author>KAMI, Masahiro ; TANAKA, Yuji ; CHIBA, Shigeru ; MATSUMURA, Tomoko ; MACHIDA, Utako ; KANDA, Yoshinobu ; NAKAGAWA, Keiichi ; MITSUHASHI, Tomoaki ; HIRAI, Hisamaru</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p199t-a31abb8b7ee5b8428286f0d59297f25bc07635117bd2f24928cdead1442696ad3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</topic><topic>Biological and medical sciences</topic><topic>Bone Marrow Transplantation - adverse effects</topic><topic>Bone Marrow Transplantation - mortality</topic><topic>Bone marrow, stem cells transplantation. Graft versus host reaction</topic><topic>Euthyroid Sick Syndromes - etiology</topic><topic>Female</topic><topic>Humans</topic><topic>Incidence</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Prognosis</topic><topic>Survival Rate</topic><topic>Thyroglobulin - blood</topic><topic>Thyroid Gland - physiology</topic><topic>Thyrotoxicosis - epidemiology</topic><topic>Thyrotoxicosis - etiology</topic><topic>Thyrotoxicosis - immunology</topic><topic>Transfusions. Complications. Transfusion reactions. Cell and gene therapy</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>KAMI, Masahiro</creatorcontrib><creatorcontrib>TANAKA, Yuji</creatorcontrib><creatorcontrib>CHIBA, Shigeru</creatorcontrib><creatorcontrib>MATSUMURA, Tomoko</creatorcontrib><creatorcontrib>MACHIDA, Utako</creatorcontrib><creatorcontrib>KANDA, Yoshinobu</creatorcontrib><creatorcontrib>NAKAGAWA, Keiichi</creatorcontrib><creatorcontrib>MITSUHASHI, Tomoaki</creatorcontrib><creatorcontrib>HIRAI, Hisamaru</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Transplantation</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>KAMI, Masahiro</au><au>TANAKA, Yuji</au><au>CHIBA, Shigeru</au><au>MATSUMURA, Tomoko</au><au>MACHIDA, Utako</au><au>KANDA, Yoshinobu</au><au>NAKAGAWA, Keiichi</au><au>MITSUHASHI, Tomoaki</au><au>HIRAI, Hisamaru</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Thyroid function after bone marrow transplantation : Possible association between immune-mediated thyrotoxicosis and hypothyroidism</atitle><jtitle>Transplantation</jtitle><addtitle>Transplantation</addtitle><date>2001-02-15</date><risdate>2001</risdate><volume>71</volume><issue>3</issue><spage>406</spage><epage>411</epage><pages>406-411</pages><issn>0041-1337</issn><eissn>1534-6080</eissn><coden>TRPLAU</coden><abstract>Thyroid dysfunction after bone marrow transplantation (BMT) has been investigated in many studies, and most posttransplant thyroid disorders are now recognized as a late complication of transplantation. However, these studies mainly focused on late thyroid function after BMT, and we have little information on early changes of thyroid function after BMT.
We prospectively investigated thyroid function in 57 patients receiving BMT. Serum thyroid-stimulating hormone, free triiodothyronine, and free thyroxine levels were determined at least monthly in the first 3 months, once between 3 and 12 months and once in the second year after BMT.
During the first 6 months after BMT, 24 and 7 patients were diagnosed as having euthyroid sick syndrome (ETS) and thyrotoxicosis, respectively. Of the 52 patients alive 1 year after transplantation, 9 patients were still diagnosed as having ETS, and 8 patients developed hypothyroidism. Patients with thyrotoxicosis showed similar characteristics, and the high incidence of thyrotoxicosis after BMT is a novel finding. The median for the onset of thyrotoxicosis was day 111 after transplantation. Thyrotoxicosis was transient in all of the patients, but in seven patients hypothyroidism followed, the median onset at 12 months after BMT. Serum thyroglobulin levels were elevated in five patients, and antibodies autoreactive to the thyroid gland were detected in seven patients.
Thyrotoxicosis may be a distinct clinical entity of thyroid dysfunction after BMT and may serve to predict the development of hypothyroidism. Immune-mediated thyroid injury may contribute to the development of posttransplant hypothyroidism.</abstract><cop>Hagerstown, MD</cop><pub>Lippincott</pub><pmid>11233902</pmid><doi>10.1097/00007890-200102150-00012</doi><tpages>6</tpages></addata></record> |
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| subjects | Adolescent Adult Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Biological and medical sciences Bone Marrow Transplantation - adverse effects Bone Marrow Transplantation - mortality Bone marrow, stem cells transplantation. Graft versus host reaction Euthyroid Sick Syndromes - etiology Female Humans Incidence Male Medical sciences Middle Aged Prognosis Survival Rate Thyroglobulin - blood Thyroid Gland - physiology Thyrotoxicosis - epidemiology Thyrotoxicosis - etiology Thyrotoxicosis - immunology Transfusions. Complications. Transfusion reactions. Cell and gene therapy |
| title | Thyroid function after bone marrow transplantation : Possible association between immune-mediated thyrotoxicosis and hypothyroidism |
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