Evaluation of chemical enhancers in the transdermal delivery of lidocaine

The effect of various classes of chemical enhancers was investigated for the transdermal delivery of the anesthetic lidocaine across pig and human skin in vitro. The lipid disrupting agents (LDA) oleic acid, oleyl alcohol, butenediol, and decanoic acid by themselves or in combination with isopropyl...

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Veröffentlicht in:	International journal of pharmaceutics 2006-02, Vol.308 (1), p.33-39
Hauptverfasser:	Lee, Philip J., Ahmad, Naina, Langer, Robert, Mitragotri, Samir, Prasad Shastri, V.
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Cutaneous Anesthetics, Local - administration & dosage Anesthetics, Local - chemistry Anesthetics, Local - metabolism Animals Biological and medical sciences Chemical enhancers Drug Combinations Drug Delivery Systems General pharmacology Humans Hydrophobic and Hydrophilic Interactions In Vitro Techniques Lidocaine Lidocaine - administration & dosage Lidocaine - chemistry Lidocaine - metabolism Medical sciences Myristates - administration & dosage Myristates - pharmacology n-Methyl pyrrolidone Pharmaceutic Aids - administration & dosage Pharmaceutic Aids - pharmacology Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments Pyrrolidinones - administration & dosage Pyrrolidinones - pharmacology Skin Absorption - drug effects Solubility Swine Transdermal drug delivery
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