Diagnostic efficacy of SonoVue®, a second generation contrast agent, in the assessment of extracranial carotid or peripheral arteries using colour and spectral Doppler ultrasound : a multicentre study
The purpose of this study was to demonstrate the improvement in diagnostic quality and diagnostic accuracy of SonoVue microbubble contrast-enhanced ultrasound (CE-US) versus unenhanced ultrasound imaging during the investigation of extracranial carotid or peripheral arteries. 82 patients with suspec...
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| Veröffentlicht in: | British journal of radiology 2006, Vol.79 (937), p.44-51 |
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| creator | SIDHU, P. S ALLAN, P. L LLULL, J.-B PEZZOLI, C SPINAZZI, A CATTIN, F COSGROVE, D. O DAVIES, A. H DO, D. D KARAKAGIL, S LANGHOLZ, J LEGEMATE, D. A MARTEGANI, A |
| description | The purpose of this study was to demonstrate the improvement in diagnostic quality and diagnostic accuracy of SonoVue microbubble contrast-enhanced ultrasound (CE-US) versus unenhanced ultrasound imaging during the investigation of extracranial carotid or peripheral arteries. 82 patients with suspected extracranial carotid or peripheral arterial disease received four SonoVue doses (0.3 ml, 0.6 ml, 1.2 ml and 2.4 ml) with Doppler ultrasound performed before and following each dose. Diagnostic quality of the CE-US examinations was evaluated off-site for duration of clinically useful contrast enhancement, artefact effects and percentage of examinations converted from non-diagnostic to diagnostic. Accuracy, sensitivity and specificity were assessed as agreement of CE-US diagnosis evaluated by an independent panel of experts with reference standard modality. The median duration of clinically useful signal enhancement significantly increased with increasing SonoVue doses (p< or =0.002). At the dose of 2.4 ml of SonoVue, diagnostic quality evaluated as number of inconclusive examinations significantly improved, falling from 40.7% at baseline down to 5.1%. Furthermore, SonoVue significantly (p |
| doi_str_mv | 10.1259/bjr/23954854 |
| format | Article |
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S ; ALLAN, P. L ; LLULL, J.-B ; PEZZOLI, C ; SPINAZZI, A ; CATTIN, F ; COSGROVE, D. O ; DAVIES, A. H ; DO, D. D ; KARAKAGIL, S ; LANGHOLZ, J ; LEGEMATE, D. A ; MARTEGANI, A</creator><creatorcontrib>SIDHU, P. S ; ALLAN, P. L ; LLULL, J.-B ; PEZZOLI, C ; SPINAZZI, A ; CATTIN, F ; COSGROVE, D. O ; DAVIES, A. H ; DO, D. D ; KARAKAGIL, S ; LANGHOLZ, J ; LEGEMATE, D. A ; MARTEGANI, A</creatorcontrib><description>The purpose of this study was to demonstrate the improvement in diagnostic quality and diagnostic accuracy of SonoVue microbubble contrast-enhanced ultrasound (CE-US) versus unenhanced ultrasound imaging during the investigation of extracranial carotid or peripheral arteries. 82 patients with suspected extracranial carotid or peripheral arterial disease received four SonoVue doses (0.3 ml, 0.6 ml, 1.2 ml and 2.4 ml) with Doppler ultrasound performed before and following each dose. Diagnostic quality of the CE-US examinations was evaluated off-site for duration of clinically useful contrast enhancement, artefact effects and percentage of examinations converted from non-diagnostic to diagnostic. Accuracy, sensitivity and specificity were assessed as agreement of CE-US diagnosis evaluated by an independent panel of experts with reference standard modality. The median duration of clinically useful signal enhancement significantly increased with increasing SonoVue doses (p< or =0.002). At the dose of 2.4 ml of SonoVue, diagnostic quality evaluated as number of inconclusive examinations significantly improved, falling from 40.7% at baseline down to 5.1%. Furthermore, SonoVue significantly (p<0.01) increased the accuracy, sensitivity and specificity of assessment of disease compared with baseline ultrasound. SonoVue increases the diagnostic quality of Doppler images and improves the accuracy of both spectral and colour Doppler examinations of extracranial carotid or peripheral arterial disease.</description><identifier>ISSN: 0007-1285</identifier><identifier>EISSN: 1748-880X</identifier><identifier>DOI: 10.1259/bjr/23954854</identifier><identifier>PMID: 16421404</identifier><identifier>CODEN: BJRAAP</identifier><language>eng</language><publisher>London: British Institute of Radiology</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Biological and medical sciences ; Cardiovascular system ; Carotid Artery Diseases - diagnostic imaging ; Cross-Over Studies ; Dose-Response Relationship, Drug ; Double-Blind Method ; Female ; Humans ; Investigative techniques, diagnostic techniques (general aspects) ; Male ; Medical sciences ; Middle Aged ; Peripheral Vascular Diseases - diagnostic imaging ; Phospholipids - administration & dosage ; Sensitivity and Specificity ; Sulfur Hexafluoride - administration & dosage ; Ultrasonic investigative techniques ; Ultrasonography, Doppler, Color - standards ; Ultrasonography, Doppler, Transcranial - standards</subject><ispartof>British journal of radiology, 2006, Vol.79 (937), p.44-51</ispartof><rights>2006 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c319t-97caef045d1174a177e03ebf8a88f42e74d4ff1536a05f290653f7c4d5f8b27f3</citedby><cites>FETCH-LOGICAL-c319t-97caef045d1174a177e03ebf8a88f42e74d4ff1536a05f290653f7c4d5f8b27f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,4010,27900,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=17411414$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16421404$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>SIDHU, P. S</creatorcontrib><creatorcontrib>ALLAN, P. L</creatorcontrib><creatorcontrib>LLULL, J.-B</creatorcontrib><creatorcontrib>PEZZOLI, C</creatorcontrib><creatorcontrib>SPINAZZI, A</creatorcontrib><creatorcontrib>CATTIN, F</creatorcontrib><creatorcontrib>COSGROVE, D. O</creatorcontrib><creatorcontrib>DAVIES, A. H</creatorcontrib><creatorcontrib>DO, D. D</creatorcontrib><creatorcontrib>KARAKAGIL, S</creatorcontrib><creatorcontrib>LANGHOLZ, J</creatorcontrib><creatorcontrib>LEGEMATE, D. A</creatorcontrib><creatorcontrib>MARTEGANI, A</creatorcontrib><title>Diagnostic efficacy of SonoVue®, a second generation contrast agent, in the assessment of extracranial carotid or peripheral arteries using colour and spectral Doppler ultrasound : a multicentre study</title><title>British journal of radiology</title><addtitle>Br J Radiol</addtitle><description>The purpose of this study was to demonstrate the improvement in diagnostic quality and diagnostic accuracy of SonoVue microbubble contrast-enhanced ultrasound (CE-US) versus unenhanced ultrasound imaging during the investigation of extracranial carotid or peripheral arteries. 82 patients with suspected extracranial carotid or peripheral arterial disease received four SonoVue doses (0.3 ml, 0.6 ml, 1.2 ml and 2.4 ml) with Doppler ultrasound performed before and following each dose. Diagnostic quality of the CE-US examinations was evaluated off-site for duration of clinically useful contrast enhancement, artefact effects and percentage of examinations converted from non-diagnostic to diagnostic. Accuracy, sensitivity and specificity were assessed as agreement of CE-US diagnosis evaluated by an independent panel of experts with reference standard modality. The median duration of clinically useful signal enhancement significantly increased with increasing SonoVue doses (p< or =0.002). At the dose of 2.4 ml of SonoVue, diagnostic quality evaluated as number of inconclusive examinations significantly improved, falling from 40.7% at baseline down to 5.1%. Furthermore, SonoVue significantly (p<0.01) increased the accuracy, sensitivity and specificity of assessment of disease compared with baseline ultrasound. SonoVue increases the diagnostic quality of Doppler images and improves the accuracy of both spectral and colour Doppler examinations of extracranial carotid or peripheral arterial disease.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Biological and medical sciences</subject><subject>Cardiovascular system</subject><subject>Carotid Artery Diseases - diagnostic imaging</subject><subject>Cross-Over Studies</subject><subject>Dose-Response Relationship, Drug</subject><subject>Double-Blind Method</subject><subject>Female</subject><subject>Humans</subject><subject>Investigative techniques, diagnostic techniques (general aspects)</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Peripheral Vascular Diseases - diagnostic imaging</subject><subject>Phospholipids - administration & dosage</subject><subject>Sensitivity and Specificity</subject><subject>Sulfur Hexafluoride - administration & dosage</subject><subject>Ultrasonic investigative techniques</subject><subject>Ultrasonography, Doppler, Color - standards</subject><subject>Ultrasonography, Doppler, Transcranial - standards</subject><issn>0007-1285</issn><issn>1748-880X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkc2O1DAQhC0EYoeFG2fkC5wmrJ3YscMN7fInrcSBH3GLepz2rFeZOLgdiXkpHoIbb4WjHbQnq9qfqlpdjD2X4rWsdXexu00XddNpZbV6wDbSKFtZK348ZBshhKlkbfUZe0J0u0rdicfsTLaqlkqoDft7FWA_RcrBcfQ-OHBHHj3_Eqf4fcE_v7ccOKGL08D3OGGCHOLEi84JKHMow7zlYeL5BjkQIdGhjFYP_FUYl2AKMHIHKeYw8Jj4jCnMN8Vq5JByEUh8oTDti-0Yl8ShhNGMLq_IVZznERNfxjUxLuXvTdnpUHRwJSkhp7wMx6fskYeR8NnpPWff3r_7evmxuv784dPl2-vKNbLLVWccoBdKD7KcCqQxKBrceQvWelWjUYPyXuqmBaF93YlWN944NWhvd7XxzTl7dec7p_hzQcr9IZDDcYQJ40K9Ea01UrYF3N6BLkWihL6fUzhAOvZS9Gt1famu_19dwV-cfJfdAYd7-NRVAV6eACAHoy-HdYHuOaOkVFI1_wDSr6e9</recordid><startdate>2006</startdate><enddate>2006</enddate><creator>SIDHU, P. S</creator><creator>ALLAN, P. L</creator><creator>LLULL, J.-B</creator><creator>PEZZOLI, C</creator><creator>SPINAZZI, A</creator><creator>CATTIN, F</creator><creator>COSGROVE, D. O</creator><creator>DAVIES, A. H</creator><creator>DO, D. D</creator><creator>KARAKAGIL, S</creator><creator>LANGHOLZ, J</creator><creator>LEGEMATE, D. A</creator><creator>MARTEGANI, A</creator><general>British Institute of Radiology</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>2006</creationdate><title>Diagnostic efficacy of SonoVue®, a second generation contrast agent, in the assessment of extracranial carotid or peripheral arteries using colour and spectral Doppler ultrasound : a multicentre study</title><author>SIDHU, P. S ; ALLAN, P. L ; LLULL, J.-B ; PEZZOLI, C ; SPINAZZI, A ; CATTIN, F ; COSGROVE, D. O ; DAVIES, A. H ; DO, D. D ; KARAKAGIL, S ; LANGHOLZ, J ; LEGEMATE, D. 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S</creatorcontrib><creatorcontrib>ALLAN, P. L</creatorcontrib><creatorcontrib>LLULL, J.-B</creatorcontrib><creatorcontrib>PEZZOLI, C</creatorcontrib><creatorcontrib>SPINAZZI, A</creatorcontrib><creatorcontrib>CATTIN, F</creatorcontrib><creatorcontrib>COSGROVE, D. O</creatorcontrib><creatorcontrib>DAVIES, A. H</creatorcontrib><creatorcontrib>DO, D. D</creatorcontrib><creatorcontrib>KARAKAGIL, S</creatorcontrib><creatorcontrib>LANGHOLZ, J</creatorcontrib><creatorcontrib>LEGEMATE, D. A</creatorcontrib><creatorcontrib>MARTEGANI, A</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>British journal of radiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>SIDHU, P. S</au><au>ALLAN, P. L</au><au>LLULL, J.-B</au><au>PEZZOLI, C</au><au>SPINAZZI, A</au><au>CATTIN, F</au><au>COSGROVE, D. O</au><au>DAVIES, A. H</au><au>DO, D. D</au><au>KARAKAGIL, S</au><au>LANGHOLZ, J</au><au>LEGEMATE, D. A</au><au>MARTEGANI, A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Diagnostic efficacy of SonoVue®, a second generation contrast agent, in the assessment of extracranial carotid or peripheral arteries using colour and spectral Doppler ultrasound : a multicentre study</atitle><jtitle>British journal of radiology</jtitle><addtitle>Br J Radiol</addtitle><date>2006</date><risdate>2006</risdate><volume>79</volume><issue>937</issue><spage>44</spage><epage>51</epage><pages>44-51</pages><issn>0007-1285</issn><eissn>1748-880X</eissn><coden>BJRAAP</coden><abstract>The purpose of this study was to demonstrate the improvement in diagnostic quality and diagnostic accuracy of SonoVue microbubble contrast-enhanced ultrasound (CE-US) versus unenhanced ultrasound imaging during the investigation of extracranial carotid or peripheral arteries. 82 patients with suspected extracranial carotid or peripheral arterial disease received four SonoVue doses (0.3 ml, 0.6 ml, 1.2 ml and 2.4 ml) with Doppler ultrasound performed before and following each dose. Diagnostic quality of the CE-US examinations was evaluated off-site for duration of clinically useful contrast enhancement, artefact effects and percentage of examinations converted from non-diagnostic to diagnostic. Accuracy, sensitivity and specificity were assessed as agreement of CE-US diagnosis evaluated by an independent panel of experts with reference standard modality. The median duration of clinically useful signal enhancement significantly increased with increasing SonoVue doses (p< or =0.002). At the dose of 2.4 ml of SonoVue, diagnostic quality evaluated as number of inconclusive examinations significantly improved, falling from 40.7% at baseline down to 5.1%. Furthermore, SonoVue significantly (p<0.01) increased the accuracy, sensitivity and specificity of assessment of disease compared with baseline ultrasound. SonoVue increases the diagnostic quality of Doppler images and improves the accuracy of both spectral and colour Doppler examinations of extracranial carotid or peripheral arterial disease.</abstract><cop>London</cop><pub>British Institute of Radiology</pub><pmid>16421404</pmid><doi>10.1259/bjr/23954854</doi><tpages>8</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0007-1285 |
| ispartof | British journal of radiology, 2006, Vol.79 (937), p.44-51 |
| issn | 0007-1285 1748-880X |
| language | eng |
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| source | Oxford University Press Journals All Titles (1996-Current); MEDLINE |
| subjects | Adult Aged Aged, 80 and over Biological and medical sciences Cardiovascular system Carotid Artery Diseases - diagnostic imaging Cross-Over Studies Dose-Response Relationship, Drug Double-Blind Method Female Humans Investigative techniques, diagnostic techniques (general aspects) Male Medical sciences Middle Aged Peripheral Vascular Diseases - diagnostic imaging Phospholipids - administration & dosage Sensitivity and Specificity Sulfur Hexafluoride - administration & dosage Ultrasonic investigative techniques Ultrasonography, Doppler, Color - standards Ultrasonography, Doppler, Transcranial - standards |
| title | Diagnostic efficacy of SonoVue®, a second generation contrast agent, in the assessment of extracranial carotid or peripheral arteries using colour and spectral Doppler ultrasound : a multicentre study |
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