The use of citric acid to prolong the in vivo gastro-retention of a floating dosage form in the fasted state

Gastro-retentive dosage forms have the potential to improve local therapy and decrease the variation in bioavailability that is observed with a number of commercially available immediate and modified release preparations. In this study, a dosage form has been developed, utilising freeze-dried calciu...

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Veröffentlicht in:	International journal of pharmaceutics 2006-02, Vol.308 (1), p.8-13
Hauptverfasser:	Stops, Frances, Fell, John T., Collett, John H., Martini, Luigi G., Sharma, Harbans L., Smith, Anne-Marie
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Alginate Alginates - administration & dosage Alginates - chemistry Beads Biological and medical sciences Citric acid Citric Acid - pharmacology Delayed-Action Preparations Drug Carriers - administration & dosage Fasting Floating dosage forms Gastric Emptying - drug effects Gastric retention Gastrointestinal Tract - diagnostic imaging Gastrointestinal Transit - drug effects General pharmacology Glucuronic Acid - administration & dosage Glucuronic Acid - chemistry Hexuronic Acids - administration & dosage Hexuronic Acids - chemistry Humans Hydrogen-Ion Concentration Male Medical sciences Middle Aged Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments Radionuclide Imaging Radiopharmaceuticals Scintigraphy Sodium Pertechnetate Tc 99m Solubility Surface Properties
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