Structure and Stability of Hereditary Spherocytosis Mutants of the Cytosolic Domain of the Erythrocyte Anion Exchanger 1 Protein

Anion exchanger 1 (AE1, Band 3) is the predominant membrane protein of erythrocytes. Its 52 kDa C-terminal domain functions as a chloride−bicarbonate exchanger, while its 43 kDa N-terminal cytosolic domain (cdb3) anchors the cytoskeleton to the membrane. Several proteins bind to cdb3, including prot...

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