Different roles of liver X receptor α and β in lipid metabolism: Effects of an α-selective and a dual agonist in mice deficient in each subtype

Liver X receptor (LXR) α and LXRβ are closely related nuclear receptors that respond to elevated levels of intracellular cholesterol by enhancing transcription of genes that control cholesterol efflux and fatty acid biosynthesis. The consequences of inactivation of either LXR isoform have been thoro...

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Veröffentlicht in:	Biochemical pharmacology 2006-02, Vol.71 (4), p.453-463
Hauptverfasser:	Lund, Erik G., Peterson, Laurence B., Adams, Alan D., Lam, My-Hanh N., Burton, Charlotte A., Chin, Jayne, Guo, Qiu, Huang, Shaei, Latham, Melanie, Lopez, Jacqueline C., Menke, John G., Milot, Denise P., Mitnaul, Lyndon J., Rex-Rabe, Sandra E., Rosa, Raymond L., Tian, Jenny Y., Wright, Samuel D., Sparrow, Carl P.
Format:	Artikel
Sprache:	eng
Schlagworte:	8-Bromo Cyclic Adenosine Monophosphate - pharmacology Administration, Oral Animals ATP Binding Cassette Transporter 1 ATP-binding cassette transporter A1 ATP-Binding Cassette Transporters - genetics ATP-Binding Cassette Transporters - metabolism Biological and medical sciences Cholesterol Cholesterol - metabolism Cholesterol, HDL - blood Cholesterol, HDL - metabolism Cyclic AMP - pharmacology DNA-Binding Proteins - agonists DNA-Binding Proteins - genetics DNA-Binding Proteins - physiology Dose-Response Relationship, Drug Gene Expression Regulation - drug effects High density lipoprotein Isoxazoles - pharmacology Lipid Metabolism - physiology Liver - drug effects Liver - metabolism Liver X Receptors Macrophages Macrophages, Peritoneal - drug effects Macrophages, Peritoneal - metabolism Medical sciences Mice Mice, Inbred C57BL Mice, Knockout Molecular Structure Nuclear receptor Orphan Nuclear Receptors Pharmacology. Drug treatments Phenylurea Compounds - pharmacology Protein Isoforms - agonists Protein Isoforms - genetics Protein Isoforms - physiology Pyrazines - pharmacology Receptors, Cytoplasmic and Nuclear - agonists Receptors, Cytoplasmic and Nuclear - genetics Receptors, Cytoplasmic and Nuclear - physiology Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - genetics RNA, Messenger - metabolism Sterol Regulatory Element Binding Protein 1 - genetics Sterol Regulatory Element Binding Protein 1 - metabolism Sterol regulatory element-binding protein-1c Triglycerides Triglycerides - blood Triglycerides - metabolism
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