Virus-Induced Abl and Fyn Kinase Signals Permit Coxsackievirus Entry through Epithelial Tight Junctions

Group B coxsackieviruses (CVBs) must cross the epithelium as they initiate infection, but the mechanism by which this occurs remains uncertain. The coxsackievirus and adenovirus receptor (CAR) is a component of the tight junction and is inaccessible to virus approaching from the apical surface. Many...

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Veröffentlicht in:	Cell 2006-01, Vol.124 (1), p.119-131
Hauptverfasser:	Coyne, Carolyn B., Bergelson, Jeffrey M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Actins - physiology Adenovirus Caco-2 Cells Caveolin 1 - metabolism CD55 Antigens - metabolism Coxsackievirus Cytoskeleton - physiology Cytoskeleton - virology Enterovirus B, Human - metabolism Epithelial Cells - metabolism Epithelial Cells - virology Humans Phosphorylation Proto-Oncogene Proteins c-abl - metabolism Proto-Oncogene Proteins c-fyn - metabolism Signal Transduction - physiology src-Family Kinases - metabolism Tight Junctions - physiology Tight Junctions - virology Tumor Cells, Cultured
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