A preliminary investigation into the action of anagrelide: Thrombopoietin–c-Mpl receptor interactions

Many studies have validated the clinical efficacy of anagrelide to reduce platelet counts in thrombocythemic conditions. With the ability to support human megakaryopoiesis in vitro using thrombopoietin (TPO), specific investigation of changes in platelet levels can be carried out in human systems. U...

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Veröffentlicht in:	Experimental hematology 2006, Vol.34 (1), p.87-96
Hauptverfasser:	McCarty, John M., Melone, Pamela D., Simanis, Juris P., Kanamori, David, Dessypris, Emmanuel N., Warshamana-Greene, G. Sakuntala
Format:	Artikel
Sprache:	eng
Schlagworte:	Antigens, CD34 - drug effects Antigens, CD34 - metabolism Cell Differentiation - drug effects Cell Line Cell Proliferation - drug effects Cells, Cultured Dose-Response Relationship, Drug Hematopoietic Stem Cells - cytology Hematopoietic Stem Cells - drug effects Hematopoietic Stem Cells - metabolism Humans In Vitro Techniques Interleukin-3 - pharmacology Models, Biological Phosphotyrosine - drug effects Phosphotyrosine - metabolism Platelet Aggregation Inhibitors - pharmacology Platelet Membrane Glycoprotein IIb - drug effects Platelet Membrane Glycoprotein IIb - metabolism Ploidies Proto-Oncogene Proteins - drug effects Proto-Oncogene Proteins - metabolism Quinazolines - pharmacology Receptors, Cytokine - drug effects Receptors, Cytokine - metabolism Receptors, Thrombopoietin Thrombopoietin - metabolism Thrombopoietin - pharmacology
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