The Central Role of the Alternative Complement Pathway in Human Disease
The complement system is increasingly recognized as important in the pathogenesis of tissue injury in vivo following immune, ischemic, or infectious insults. Within the complement system, three pathways are capable of initiating the processes that result in C3 activation: classical, alternative, and...
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Veröffentlicht in: | Journal of Immunology 2006-02, Vol.176 (3), p.1305-1310 |
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description | The complement system is increasingly recognized as important in the pathogenesis of tissue injury in vivo following immune, ischemic, or infectious insults. Within the complement system, three pathways are capable of initiating the processes that result in C3 activation: classical, alternative, and lectin. Although the roles that proinflammatory peptides and complexes generated during complement activation play in mediating disease processes have been studied extensively, the relative contributions of the three activating pathways is less well understood. Herein we examine recent evidence that the alternative complement pathway plays a key and, in most instances, obligate role in generating proinflammatory complement activation products in vivo. In addition, we discuss new concepts regarding the mechanisms by which the alternative pathway is activated in vivo, as recent clinical findings and experimental results have provided evidence that continuous active control of this pathway is necessary to prevent unintended targeting and injury to self tissues. |
doi_str_mv | 10.4049/jimmunol.176.3.1305 |
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In addition, we discuss new concepts regarding the mechanisms by which the alternative pathway is activated in vivo, as recent clinical findings and experimental results have provided evidence that continuous active control of this pathway is necessary to prevent unintended targeting and injury to self tissues.</description><subject>Complement Pathway, Alternative - immunology</subject><subject>Humans</subject><subject>Immune System Diseases - immunology</subject><subject>Immune System Diseases - metabolism</subject><issn>0022-1767</issn><issn>1550-6606</issn><issn>1365-2567</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkEtLw0AUhQdRtD5-gSBZ6SrxTubVLEt9VCgoUtfDJL2xkZmkZhJD_71TWtGdqwv3fOcsPkIuKSQceHb7UTnX141NqJIJSygDcUBGVAiIpQR5SEYAaRqHVJ2QU-8_AEBCyo_JCZU85VTwEXlcrDCaYt21xkavjcWoKaMu_Ca2w7Y2XfUV8satLbpARS-mWw1mE1V1NOudqaO7yqPxeE6OSmM9XuzvGXl7uF9MZ_H8-fFpOpnHBVeqizFfjrkp5dhIliEI4BxknqMqRJZlyISCnDNZpKmgZWZUllIOgi6ZyVWhDGdn5Hq3u26bzx59p13lC7TW1Nj0XiuQ49Ad_wtSxaXgsAXZDizaxvsWS71uK2fajaagt6L1j-jQkZrprejQutrP97nD5W9nbzYANztgVb2vhqpF7Z2xNuBUD8PwZ-obilmHqg</recordid><startdate>20060201</startdate><enddate>20060201</enddate><creator>Thurman, Joshua M</creator><creator>Holers, V. 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Michael</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c477t-ebd84af68a639e0504406bbe7c5999e3570b436c2251f9a79214051d3ab7c7a43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Complement Pathway, Alternative - immunology</topic><topic>Humans</topic><topic>Immune System Diseases - immunology</topic><topic>Immune System Diseases - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Thurman, Joshua M</creatorcontrib><creatorcontrib>Holers, V. 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Michael</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The Central Role of the Alternative Complement Pathway in Human Disease</atitle><jtitle>Journal of Immunology</jtitle><addtitle>J Immunol</addtitle><date>2006-02-01</date><risdate>2006</risdate><volume>176</volume><issue>3</issue><spage>1305</spage><epage>1310</epage><pages>1305-1310</pages><issn>0022-1767</issn><eissn>1550-6606</eissn><eissn>1365-2567</eissn><abstract>The complement system is increasingly recognized as important in the pathogenesis of tissue injury in vivo following immune, ischemic, or infectious insults. Within the complement system, three pathways are capable of initiating the processes that result in C3 activation: classical, alternative, and lectin. 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subjects | Complement Pathway, Alternative - immunology Humans Immune System Diseases - immunology Immune System Diseases - metabolism |
title | The Central Role of the Alternative Complement Pathway in Human Disease |
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