Inhibition of the phosphatidylinositol‐3 kinase/Akt promotes G1 cell cycle arrest and apoptosis in Hodgkin lymphoma

Summary Activation of the phosphatidylinositol 3‐kinase (PI3K) pathway has been linked with tumour cell growth, survival and resistance to therapy in several cancer types. The active, phosphorylated form of Akt (pAkt) was found to be aberrantly expressed in Hodgkin lymphoma (HL)‐derived cell lines a...

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Veröffentlicht in:	British journal of haematology 2006-02, Vol.132 (4), p.503-511
Hauptverfasser:	Georgakis, Georgios V., Li, Yang, Rassidakis, Georgios Z., Medeiros, L. Jeffrey, Mills, Gordon B., Younes, Anas
Format:	Artikel
Sprache:	eng
Schlagworte:	Akt Antigens, CD - pharmacology Apoptosis Biological and medical sciences Carrier Proteins - pharmacology Caspase 9 Caspases - metabolism CD30 CD30 Ligand CD40 CD40 Ligand - pharmacology Cell Line, Tumor Cell Proliferation - drug effects Cells, Cultured Chromones - pharmacology Cyclin D1 - metabolism Dose-Response Relationship, Drug Flow Cytometry G1 Phase Hematologic and hematopoietic diseases Hematology Hodgkin Disease - metabolism Hodgkin Disease - pathology Hodgkin lymphoma Humans Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Medical sciences Membrane Glycoproteins - pharmacology Morpholines - pharmacology Phosphatidylinositol 3-Kinases - analysis Phosphatidylinositol 3-Kinases - antagonists & inhibitors Phosphorylation Proto-Oncogene Proteins c-akt - analysis Proto-Oncogene Proteins c-akt - antagonists & inhibitors PTEN Phosphohydrolase - analysis PTEN Phosphohydrolase - metabolism RANK Ligand Receptor Activator of Nuclear Factor-kappa B Tumor Necrosis Factors - pharmacology
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