Vascular endothelial growth factor-B (VEGFB) stimulates neurogenesis: Evidence from knockout mice and growth factor administration

Vascular endothelial growth factor-B (VEGFB) is an angiogenic and neuroprotective protein that reduces hypoxic and ischemic neuronal injury. To determine if VEGFB also regulates neurogenesis in the adult brain, we studied the effects of VEGFB administration in vitro and in vivo, as well as the effec...

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Veröffentlicht in:	Developmental biology 2006-01, Vol.289 (2), p.329-335
Hauptverfasser:	Sun, Yunjuan, Jin, Kunlin, Childs, Jocelyn T., Xie, Lin, Mao, Xiao Ou, Greenberg, David A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiogenesis Animals Brain - cytology Brain - metabolism Cells, Cultured In Vitro Techniques Injections, Intraventricular Male Mice Mice, Knockout Neurogenesis Neurons - drug effects Neurons - metabolism Neurons - physiology Rats Rats, Sprague-Dawley Vascular Endothelial Growth Factor A - metabolism Vascular Endothelial Growth Factor A - pharmacology Vascular Endothelial Growth Factor B - metabolism Vascular Endothelial Growth Factor B - pharmacology Vascular Endothelial Growth Factor B - physiology Vascular endothelial growth factor-B
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