Altered expression of disintegrin metalloproteinases and their inhibitor in human dilated cardiomyopathy

Disintegrin metalloproteinases (ADAMs) may contribute to structural cardiac remodeling by altering cell-surface matrix receptors (integrins) and activating potent biomolecules. We compared expression of ADAMs, their endogenous inhibitor tissue inhibitor of metalloproteinases (TIMP)-3, and integrins...

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Veröffentlicht in:	Circulation (New York, N.Y.) N.Y.), 2006-01, Vol.113 (2), p.238-245
Hauptverfasser:	FEDAK, Paul W. M, MORAVEC, Christine S, MCCARTHY, Patrick M, ALTAMENTOVA, Svetlana M, WONG, Amy P, SKRTIC, Marko, VERMA, Subodh, WEISEL, Richard D, LI, Ren-Ke
Format:	Artikel
Sprache:	eng
Schlagworte:	ADAM Proteins - analysis ADAM Proteins - antagonists & inhibitors ADAM10 Protein ADAM12 Protein ADAM17 Protein Adolescent Adult Aged Amyloid Precursor Protein Secretases Biological and medical sciences Blood and lymphatic vessels Blood vessels and receptors Cardiology. Vascular system Cardiomyopathy, Dilated - enzymology Cardiomyopathy, Dilated - genetics Cardiomyopathy, Dilated - pathology Cardiovascular system Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous Female Fundamental and applied biological sciences. Psychology Gene Expression Regulation, Enzymologic Humans Immunoblotting Integrin beta1 - analysis Integrin beta3 - analysis Male Medical sciences Membrane Proteins - analysis Middle Aged Myocardium - enzymology Myocardium - pathology Pharmacology. Drug treatments Protease Inhibitors Tissue Inhibitor of Metalloproteinase-3 - analysis Vasodilator agents. Cerebral vasodilators Vertebrates: cardiovascular system
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