Neuronal and astrocytic shuttle mechanisms for cytosolic-mitochondrial transfer of reducing equivalents: Current evidence and pharmacological tools

The malate–aspartate shuttle and the glycerol phosphate shuttle act to transfer reducing equivalents from NADH in the cytosol to the mitochondria since the inner mitochondrial membrane is impermeable to NADH and NAD +. This transfer of reducing equivalents is essential for maintaining a favorable NA...

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Veröffentlicht in:	Biochemical pharmacology 2006-02, Vol.71 (4), p.399-407
Hauptverfasser:	McKenna, Mary C., Waagepetersen, Helle S., Schousboe, Arne, Sonnewald, Ursula
Format:	Artikel
Sprache:	eng
Schlagworte:	3-NPA AGC1 Animals AOAA aralar1 Aspartate aminotransferase Aspartate–glutamate carrier Aspartic Acid - metabolism Astrocytes Astrocytes - metabolism Biological Transport - drug effects Biological Transport - physiology BMA Cytosol - metabolism Energy metabolism Glycerol 3-phosphate shuttle Glycerophosphates - metabolism Malate dehydrogenase Malates - metabolism Malate–aspartate shuttle Malate–α-ketoglutarate carrier Mitochondria - metabolism Models, Biological NAD - metabolism Neuronal and astrocytic shuttle mechanisms Neurons Neurons - metabolism Oxidation-Reduction Phenylsuccinate Synaptosomes
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