Lipid Profiling by Multiple Precursor and Neutral Loss Scanning Driven by the Data-Dependent Acquisition

Data-dependent acquisition of MS/MS spectra from lipid precursors enables to emulate the simultaneous acquisition of an unlimited number of precursor and neutral loss scans in a single analysis. This approach takes full advantage of rich fragment patterns in tandem mass spectra of lipids and enables...

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Veröffentlicht in:Analytical chemistry (Washington) 2006-01, Vol.78 (2), p.585-595
Hauptverfasser: Schwudke, Dominik, Oegema, Jeffrey, Burton, Lyle, Entchev, Eugeni, Hannich, J. Thomas, Ejsing, Christer S, Kurzchalia, Teymuras, Shevchenko, Andrej
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container_issue 2
container_start_page 585
container_title Analytical chemistry (Washington)
container_volume 78
creator Schwudke, Dominik
Oegema, Jeffrey
Burton, Lyle
Entchev, Eugeni
Hannich, J. Thomas
Ejsing, Christer S
Kurzchalia, Teymuras
Shevchenko, Andrej
description Data-dependent acquisition of MS/MS spectra from lipid precursors enables to emulate the simultaneous acquisition of an unlimited number of precursor and neutral loss scans in a single analysis. This approach takes full advantage of rich fragment patterns in tandem mass spectra of lipids and enables their profiling by complex (Boolean) scans, in which masses of several fragment ions are considered within a single logical framework. No separation of lipids is required, and the accuracy of identification and quantification is not compromised, compared to conventional precursor and neutral loss scanning.
doi_str_mv 10.1021/ac051605m
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subjects Analytical chemistry
Animals
Caenorhabditis elegans - chemistry
Chemistry
Chromatography, Liquid
Exact sciences and technology
Lipids
Lipids - analysis
Spectrometric and optical methods
Spectrum analysis
Tandem Mass Spectrometry - methods
title Lipid Profiling by Multiple Precursor and Neutral Loss Scanning Driven by the Data-Dependent Acquisition
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