Biochemical properties of lens-specific calpain Lp85

Lens-specific Lp82 and ubiquitous m-calpain are neutral, calcium-activated, cysteine proteases. Both calpains are activated during rodent lens maturation and cataract formation. Lp85 calpain ( Lens protein with MW=85 kDa) is a slightly larger splice variant of Lp82. Lp85 contains a 28 amino acid ins...

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Veröffentlicht in:	Experimental eye research 2006, Vol.82 (1), p.146-152
Hauptverfasser:	Shih, M., Ma, H., Nakajima, E., David, L.L., Azuma, M., Shearer, T.R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Baculoviridae - genetics Calcium - pharmacology Calcium-Binding Proteins - pharmacology calpain Calpain - analysis Calpain - genetics Calpain - metabolism cataract Electrophoresis, Polyacrylamide Gel Enzyme Activation Genetic Vectors - administration & dosage Humans Immunoblotting Insecta lens Lens, Crystalline - chemistry Lens, Crystalline - enzymology Lp82 Lp85 m-calpain Mass Spectrometry Rats Rats, Sprague-Dawley Recombinant Proteins Sequence Analysis, DNA Sequence Homology
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