Overlapping, Nonidentical Binding Sites of Different Classes of Nonpeptide Antagonists for the Human Gonadotropin-Releasing Hormone Receptor

Peptide agonists and antagonists of the human gonadotropin-releasing hormone receptor (GnRH-R) are widely used to treat a range of reproductive hormone related diseases. Recently, nonpeptide, orally available GnRH-R antagonists have emerged from several chemical classes. To understand how a relative...

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Veröffentlicht in:	Journal of medicinal chemistry 2006-01, Vol.49 (2), p.637-647
Hauptverfasser:	Betz, Stephen F, Reinhart, Greg J, Lio, Francisco M, Chen, Struthers, R. Scott
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals Binding Sites Biological and medical sciences Cercopithecus aethiops COS Cells Hormones. Endocrine system Humans Indoles - chemistry Indoles - pharmacology Ligands Medical sciences Miscellaneous Models, Molecular Molecular Sequence Data Mutation Peptides - chemistry Pharmacology. Drug treatments Phenylurea Compounds - chemistry Phenylurea Compounds - pharmacology Point Mutation Protein Structure, Secondary Protein Structure, Tertiary Pyrimidinones - chemistry Pyrimidinones - pharmacology Radioligand Assay Receptors, LHRH - agonists Receptors, LHRH - antagonists & inhibitors Receptors, LHRH - genetics Sequence Homology, Amino Acid Structure-Activity Relationship Thymine - analogs & derivatives Thymine - chemistry Thymine - pharmacology
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