Elevated expression of ISG15 in tumor cells interferes with the ubiquitin/26S proteasome pathway

IFN-stimulatory gene factor 15 (ISG15) is a ubiquitin-like protein, which is conjugated to many cellular proteins. However, its role in protein degradation is unclear. Here, we show that ISG15 is highly elevated and extensively conjugated to cellular proteins in many tumors and tumor cell lines. The...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 2006-01, Vol.66 (2), p.921-928
Hauptverfasser:	DESAI, Shyamal D, HAAS, Arthur L, WOOD, Laurence M, TSAI, Yu-Chen, PESTKA, Sidney, RUBIN, Eric H, SALEEM, Ahamed, NUR-E-KAMAL, Alam, LIU, Leroy F
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Breast Neoplasms - genetics Breast Neoplasms - pathology Cell physiology Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes Cell Transformation, Neoplastic Cytokines - biosynthesis Cytokines - physiology Female Fundamental and applied biological sciences. Psychology Gene Expression Profiling Humans Molecular and cellular biology Proteasome Endopeptidase Complex - metabolism Proteins - metabolism RNA, Small Interfering Tumor Cells, Cultured Ubiquitin - metabolism Ubiquitins - biosynthesis Ubiquitins - physiology Up-Regulation
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