Pharmacokinetics of florfenicol and its metabolite, florfenicol amine, in the Korean catfish (Silurus asotus)
The pharmacokinetics of florfenicol and its metabolite, florfenicol amine, was investigated after its intravenous (i.v.) and oral (p.o.) administration of 20 mg/kg of body weight in Korean catfish (Silurus asotus). After i.v. florfenicol injection (as a bolus), the terminal half‐life (t1/2), the vol...
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| Veröffentlicht in: | Journal of veterinary pharmacology and therapeutics 2006-02, Vol.29 (1), p.37-40 |
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| creator | Park, B.K Lim, J.H Kim, M.S Yun, H.I |
| description | The pharmacokinetics of florfenicol and its metabolite, florfenicol amine, was investigated after its intravenous (i.v.) and oral (p.o.) administration of 20 mg/kg of body weight in Korean catfish (Silurus asotus). After i.v. florfenicol injection (as a bolus), the terminal half‐life (t1/2), the volume of distribution at steady state (Vdss), and total body clearance were 11.12 ± 1.06 h, 1.09 ± 0.09 L/kg and 0.07 ± 0.01 L·kg/h respectively. After p.o. administration of florfenicol, the t1/2, Cmax, tmax and oral bioavailability (F) were 15.69 ± 2.59 h, 9.59 ± 0.36 μg/mL, 8 h and 92.61 ± 10.1% respectively. Florfenicol amine, an active metabolite of florfenicol, was detected in all fish. After i.v. and p.o. administration of florfenicol, the observed Cmax values of florfenicol amine (3.91 ± 0.69 and 3.57 ± 0.65 mg/L) were reached at 0.5 and 7.33 ± 1.15 h. The mean metabolic rate of florfenicol amine after i.v. and p.o. administration was 0.4 and 0.5 respectively. |
| doi_str_mv | 10.1111/j.1365-2885.2006.00709.x |
| format | Article |
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After i.v. florfenicol injection (as a bolus), the terminal half‐life (t1/2), the volume of distribution at steady state (Vdss), and total body clearance were 11.12 ± 1.06 h, 1.09 ± 0.09 L/kg and 0.07 ± 0.01 L·kg/h respectively. After p.o. administration of florfenicol, the t1/2, Cmax, tmax and oral bioavailability (F) were 15.69 ± 2.59 h, 9.59 ± 0.36 μg/mL, 8 h and 92.61 ± 10.1% respectively. Florfenicol amine, an active metabolite of florfenicol, was detected in all fish. After i.v. and p.o. administration of florfenicol, the observed Cmax values of florfenicol amine (3.91 ± 0.69 and 3.57 ± 0.65 mg/L) were reached at 0.5 and 7.33 ± 1.15 h. The mean metabolic rate of florfenicol amine after i.v. and p.o. administration was 0.4 and 0.5 respectively.</description><identifier>ISSN: 0140-7783</identifier><identifier>EISSN: 1365-2885</identifier><identifier>DOI: 10.1111/j.1365-2885.2006.00709.x</identifier><identifier>PMID: 16420300</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Science Ltd</publisher><subject>Administration, Oral ; amines ; Animals ; Anti-Bacterial Agents - administration & dosage ; Anti-Bacterial Agents - metabolism ; Anti-Bacterial Agents - pharmacokinetics ; Area Under Curve ; catfish ; Catfishes ; drug evaluation ; florfenicol ; Half-Life ; Injections, Intravenous ; metabolites ; pharmacokinetics ; Silurus asotus ; Thiamphenicol - administration & dosage ; Thiamphenicol - analogs & derivatives ; Thiamphenicol - metabolism ; Thiamphenicol - pharmacokinetics ; Tissue Distribution ; veterinary medicine</subject><ispartof>Journal of veterinary pharmacology and therapeutics, 2006-02, Vol.29 (1), p.37-40</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4289-ba77dc6231b30ba50ac8b74c0644ef7b18e7c6d50501db6627de708c6a027fe93</citedby><cites>FETCH-LOGICAL-c4289-ba77dc6231b30ba50ac8b74c0644ef7b18e7c6d50501db6627de708c6a027fe93</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1365-2885.2006.00709.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1365-2885.2006.00709.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>315,781,785,1418,27929,27930,45579,45580</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16420300$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Park, B.K</creatorcontrib><creatorcontrib>Lim, J.H</creatorcontrib><creatorcontrib>Kim, M.S</creatorcontrib><creatorcontrib>Yun, H.I</creatorcontrib><title>Pharmacokinetics of florfenicol and its metabolite, florfenicol amine, in the Korean catfish (Silurus asotus)</title><title>Journal of veterinary pharmacology and therapeutics</title><addtitle>J Vet Pharmacol Ther</addtitle><description>The pharmacokinetics of florfenicol and its metabolite, florfenicol amine, was investigated after its intravenous (i.v.) and oral (p.o.) administration of 20 mg/kg of body weight in Korean catfish (Silurus asotus). After i.v. florfenicol injection (as a bolus), the terminal half‐life (t1/2), the volume of distribution at steady state (Vdss), and total body clearance were 11.12 ± 1.06 h, 1.09 ± 0.09 L/kg and 0.07 ± 0.01 L·kg/h respectively. After p.o. administration of florfenicol, the t1/2, Cmax, tmax and oral bioavailability (F) were 15.69 ± 2.59 h, 9.59 ± 0.36 μg/mL, 8 h and 92.61 ± 10.1% respectively. Florfenicol amine, an active metabolite of florfenicol, was detected in all fish. After i.v. and p.o. administration of florfenicol, the observed Cmax values of florfenicol amine (3.91 ± 0.69 and 3.57 ± 0.65 mg/L) were reached at 0.5 and 7.33 ± 1.15 h. The mean metabolic rate of florfenicol amine after i.v. and p.o. administration was 0.4 and 0.5 respectively.</description><subject>Administration, Oral</subject><subject>amines</subject><subject>Animals</subject><subject>Anti-Bacterial Agents - administration & dosage</subject><subject>Anti-Bacterial Agents - metabolism</subject><subject>Anti-Bacterial Agents - pharmacokinetics</subject><subject>Area Under Curve</subject><subject>catfish</subject><subject>Catfishes</subject><subject>drug evaluation</subject><subject>florfenicol</subject><subject>Half-Life</subject><subject>Injections, Intravenous</subject><subject>metabolites</subject><subject>pharmacokinetics</subject><subject>Silurus asotus</subject><subject>Thiamphenicol - administration & dosage</subject><subject>Thiamphenicol - analogs & derivatives</subject><subject>Thiamphenicol - metabolism</subject><subject>Thiamphenicol - pharmacokinetics</subject><subject>Tissue Distribution</subject><subject>veterinary medicine</subject><issn>0140-7783</issn><issn>1365-2885</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkMFu1DAQhi1ERZeWVwCfEJWadGwntlfiglZl21JBYSkcLcdxWG-TuNiJ2L49XrIq4sZcZqT5vrH1I4QJ5CTV2SYnjJcZlbLMKQDPAQTM8-0TNHtcPEUzIAVkQkh2iJ7HuAEAJgl5hg4JLygwgBnqbtY6dNr4O9fbwZmIfYOb1ofG9s74Fuu-xm6IuLODrnzrBnv6775L4il2PR7WFn_wweoeGz00Lq7xm5VrxzBGrKMfxnhyjA4a3Ub7Yt-P0O3786-Li-z60_Jy8e46MwWV86zSQtSGU0YqBpUuQRtZicIALwrbiIpIKwyvSyiB1BXnVNRWgDRcAxWNnbMj9Hq6ex_8z9HGQXUuGtu2urd-jEoAF_OC8ATKCTTBxxhso-6D63R4UATULmq1UbtE1S5RtYta_YlabZP6cv_GWHW2_ivus03A2wn45Vr78N-H1dW3mzQkPZt0Fwe7fdR1uFNcMFGq7x-XSi4-r5ZXF0v1JfGvJr7RXukfwUV1u6JA0lckTR3Yb7Q_pes</recordid><startdate>200602</startdate><enddate>200602</enddate><creator>Park, B.K</creator><creator>Lim, J.H</creator><creator>Kim, M.S</creator><creator>Yun, H.I</creator><general>Blackwell Science Ltd</general><scope>FBQ</scope><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200602</creationdate><title>Pharmacokinetics of florfenicol and its metabolite, florfenicol amine, in the Korean catfish (Silurus asotus)</title><author>Park, B.K ; Lim, J.H ; Kim, M.S ; Yun, H.I</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4289-ba77dc6231b30ba50ac8b74c0644ef7b18e7c6d50501db6627de708c6a027fe93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Administration, Oral</topic><topic>amines</topic><topic>Animals</topic><topic>Anti-Bacterial Agents - administration & dosage</topic><topic>Anti-Bacterial Agents - metabolism</topic><topic>Anti-Bacterial Agents - pharmacokinetics</topic><topic>Area Under Curve</topic><topic>catfish</topic><topic>Catfishes</topic><topic>drug evaluation</topic><topic>florfenicol</topic><topic>Half-Life</topic><topic>Injections, Intravenous</topic><topic>metabolites</topic><topic>pharmacokinetics</topic><topic>Silurus asotus</topic><topic>Thiamphenicol - administration & dosage</topic><topic>Thiamphenicol - analogs & derivatives</topic><topic>Thiamphenicol - metabolism</topic><topic>Thiamphenicol - pharmacokinetics</topic><topic>Tissue Distribution</topic><topic>veterinary medicine</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Park, B.K</creatorcontrib><creatorcontrib>Lim, J.H</creatorcontrib><creatorcontrib>Kim, M.S</creatorcontrib><creatorcontrib>Yun, H.I</creatorcontrib><collection>AGRIS</collection><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of veterinary pharmacology and therapeutics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Park, B.K</au><au>Lim, J.H</au><au>Kim, M.S</au><au>Yun, H.I</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Pharmacokinetics of florfenicol and its metabolite, florfenicol amine, in the Korean catfish (Silurus asotus)</atitle><jtitle>Journal of veterinary pharmacology and therapeutics</jtitle><addtitle>J Vet Pharmacol Ther</addtitle><date>2006-02</date><risdate>2006</risdate><volume>29</volume><issue>1</issue><spage>37</spage><epage>40</epage><pages>37-40</pages><issn>0140-7783</issn><eissn>1365-2885</eissn><abstract>The pharmacokinetics of florfenicol and its metabolite, florfenicol amine, was investigated after its intravenous (i.v.) and oral (p.o.) administration of 20 mg/kg of body weight in Korean catfish (Silurus asotus). After i.v. florfenicol injection (as a bolus), the terminal half‐life (t1/2), the volume of distribution at steady state (Vdss), and total body clearance were 11.12 ± 1.06 h, 1.09 ± 0.09 L/kg and 0.07 ± 0.01 L·kg/h respectively. After p.o. administration of florfenicol, the t1/2, Cmax, tmax and oral bioavailability (F) were 15.69 ± 2.59 h, 9.59 ± 0.36 μg/mL, 8 h and 92.61 ± 10.1% respectively. Florfenicol amine, an active metabolite of florfenicol, was detected in all fish. After i.v. and p.o. administration of florfenicol, the observed Cmax values of florfenicol amine (3.91 ± 0.69 and 3.57 ± 0.65 mg/L) were reached at 0.5 and 7.33 ± 1.15 h. The mean metabolic rate of florfenicol amine after i.v. and p.o. administration was 0.4 and 0.5 respectively.</abstract><cop>Oxford, UK</cop><pub>Blackwell Science Ltd</pub><pmid>16420300</pmid><doi>10.1111/j.1365-2885.2006.00709.x</doi><tpages>4</tpages></addata></record> |
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| subjects | Administration, Oral amines Animals Anti-Bacterial Agents - administration & dosage Anti-Bacterial Agents - metabolism Anti-Bacterial Agents - pharmacokinetics Area Under Curve catfish Catfishes drug evaluation florfenicol Half-Life Injections, Intravenous metabolites pharmacokinetics Silurus asotus Thiamphenicol - administration & dosage Thiamphenicol - analogs & derivatives Thiamphenicol - metabolism Thiamphenicol - pharmacokinetics Tissue Distribution veterinary medicine |
| title | Pharmacokinetics of florfenicol and its metabolite, florfenicol amine, in the Korean catfish (Silurus asotus) |
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